1. Nako ea Prothrombin (PT)

Haholo-holo e bonahatsa boemo ba exogenous coagulation system, eo hangata INR e sebelisoang ho beha leihlo li-anticoagulants tsa molomo.PT ke sesupo sa bohlokoa bakeng sa tlhahlobo ea boemo ba prethrombotic, DIC le lefu la sebete.E sebelisoa e le tlhahlobo ea tlhahlobo bakeng sa sistimi ea exogenous coagulation hape ke mokhoa oa bohlokoa oa taolo ea lethal dose ea oral anticoagulation.

PTA <40% e bonts'a necrosis e kholo ea lisele tsa sebete le ho fokotseha ha motsoako oa lintlha tsa coagulation.Ka mohlala, 30%

Ho lelefatsa ho bonoa ho:

a.Tšenyo e kholo le e tebileng ea sebete e bakoa haholo ke ho hlahisa prothrombin le lintlha tse amanang le ho koala.

b.VitK e sa lekaneng, VitK e hlokeha ho kopanya lintlha tsa II, VII, IX, le X. Ha VitK e sa lekana, tlhahiso e fokotseha 'me nako ea prothrombin e lelefalitsoe.E boetse e bonoa ho obstructive jaundice.

C. DIC (diffuse intravascular coagulation), e jang palo e kholo ea mabaka a coagulation ka lebaka la microvascular thrombosis e pharaletseng.

d.Neonatal spontaneous hemorrhage, congenital prothrombin khaello ea anticoagulant kalafo.

E khutsufalitsoe ho:

Ha mali a le boemong ba hypercoagulable (joaloka DIC ea pele, myocardial infarction), mafu a thrombotic (a kang cerebral thrombosis), joalo-joalo.

 

2. Nako ea Thrombin (TT)

Haholo-holo e bonahatsa nako eo fibrinogen e fetohang fibrin.

Ho lelefatsa ho bonoa ka: ho eketseha ha heparin kapa lintho tsa heparinoid, ho eketseha ha ts'ebetso ea AT-III, palo e sa tloaelehang le boleng ba fibrinogen.DIC hyperfibrinolysis stage, low (no) fibrinogenemia, abnormal hemoglobinemia, blood fibrin (proto) degradation products (FDPs) e ile ea eketseha.

Phokotso ha e na bohlokoa ba kliniki.

 

3. Activated partial thromboplastin time (APTT)

E bonts'a haholo boemo ba "endogenous coagulation system" mme e sebelisoa hangata ho lekola litekanyetso tsa heparin.E bonts'a maemo a coagulation factor VIII, IX, XI, XII ka plasma, ke tlhahlobo ea tlhahlobo ea endogenous coagulation system.APTT hangata e sebelisoa ho beha leihlo kalafo ea anticoagulation ea heparin.

Ho lelefatsa ho bonoa ho:

a.Ho haella ha lintlha tsa coagulation VIII, IX, XI, XII:

b.Coagulation factor II, V, X le ho fokotsa fibrinogen ba fokolang;

C. Ho na le lintho tsa anticoagulant tse kang heparin;

d, lihlahisoa tsa ho senyeha ha fibrinogen li ile tsa eketseha;e, DIC.

E khutsufalitsoe ho:

Boemo ba Hypercoagulable: Haeba ntho ea procoagulant e kena maling mme ts'ebetso ea lintlha tsa coagulation e eketseha, joalo-joalo:

 

4.Plasma fibrinogen (FIB)

Haholo-holo e bonahatsa litaba tsa fibrinogen.Plasma fibrinogen ke protheine ea coagulation e nang le litaba tse phahameng ka ho fetisisa tsa lintho tsohle tsa coagulation, 'me ke karolo e matla ea karabelo.

Keketseho bonoa: chesa, lefu la tsoekere, tšoaetso a hlobaetsang le, a hlobaetsang le lefuba, kankere, subacute baktheria endocarditis, bokhachane, pneumonia, cholecystitis, pericarditis, sepsis, nephrotic syndrome, uremia, a hlobaetsang le myocardial infarction.

Phokotso e bonoang ho: Congenital fibrinogen abnormality, DIC e senya hypocoagulation phase, primary fibrinolysis, lefu la sebete le matla, sebete sa sebete.

 

5.D-Dimer (D-Dimer)

Haholo-holo e bonahatsa mosebetsi oa fibrinolysis 'me ke sesupo sa ho fumana hore na ho ba teng kapa ho ba sieo ha thrombosis le fibrinolysis ea bobeli' meleng.

D-dimer ke sehlahisoa se khethehileng sa ho senyeha ha fibrin e amanang le sefapano, e ntseng e eketseha ka plasma feela ka mor'a thrombosis, kahoo ke letšoao la bohlokoa la limolek'hule bakeng sa tlhahlobo ea thrombosis.

D-dimer e eketsehile haholo ho fibrinolysis hyperactivity ea bobeli, empa ha e eketsehe ho ts'ebetso ea mantlha ea fibrinolysis, e leng sesupo sa bohlokoa sa ho khetholla tse peli.

Keketseho e bonoa mafung a kang deep vein thrombosis, pulmonary embolism, le DIC secondary hyperfibrinolysis.