1. Nguva yeProthrombin (PT)

Inonyanya kuratidza mamiriro e exogenous coagulation system, umo INR inowanzo shandiswa kutarisa mishonga inorwisa ropa. PT chiratidzo chakakosha chekuongorora mamiriro e prethrombotic state, DIC uye chirwere chechiropa. Inoshandiswa seyedzo yekuongorora exogenous coagulation system uye zvakare inzira yakakosha yekurapa nemuromo inorwisa ropa kudzora dose.

PTA<40% inoratidza kuvharika kukuru kwemasero echiropa uye kudzikira kwekugadzirwa kwezvinhu zvinosunga maronda. Semuenzaniso, 30%

Kuwedzerwa kwenguva kunoonekwa mu:

a. Kukuvadzwa kwechiropa kwakanyanya uye kwakakomba kunokonzerwa nekuumbwa kweprothrombin nezvimwe zvinhu zvine chekuita nekugwamba kweropa.

b. Kusakwana kweVitK, VitK inodiwa kuti pave nezvikamu zviviri, zvina, zvina, zvina, uye zvina, zvichigadzira zvinhu zviviri, zvina ...

C. DIC (diffuse intravascular coagulation), iyo inoshandisa huwandu hwakawanda hwezvinhu zvinokonzera kugwinha kweropa nekuda kwe microvascular thrombosis yakakura.

d. Kubuda ropa kwepachivande kwevana vacheche, kushaya mushonga wekudzivirira ropa kubva muropa panguva yekuzvarwa.

Kupfupisa kunoonekwa mu:

Kana ropa riine chirwere chekukanda ropa zvakanyanya (senge DIC yekutanga, myocardial infarction), zvirwere zvethrombotic (senge cerebral thrombosis), nezvimwewo.

 

2. Nguva yeTrombin (TT)

Inonyanya kuratidza nguva iyo fibrinogen inoshanduka kuita fibrin.

Kureba kwenguva kunoonekwa mu: kuwedzera kweheparin kana heparinoid substances, kuwedzera kweAT-III activity, huwandu husina kujairika uye mhando yefibrinogen. DIC hyperfibrinolysis stage, low (no) fibrinogenemia, abnormal hemoglobinemia, blood fibrin (proto) degradation products (FDPs) yakawedzera.

Kudzikiswa kwechirwere hakunei nepfungwa yekurapa.

 

3. Nguva yekubvisa thromboplastin (APTT) yakabatidzwa

Inonyanya kuratidza mamiriro e endogenous coagulation system uye inowanzoshandiswa kuongorora huwandu hwe heparin. Ichiratidza huwandu hwe coagulation factors VIII, IX, XI, XII mu plasma, iyi iongororo ye endogenous coagulation system. APTT inowanzoshandiswa kuongorora heparin anticoagulation therapy.

Kuwedzerwa kwenguva kunoonekwa mu:

a. Kushaikwa kwezvinhu zvinobatanidza ropa VIII, IX, XI, XII:

b. Kuderedza kweCoagulation factor II, V, X uye fibrinogen vashoma;

C. Kune zvinhu zvinorwisa ropa kupwanya ropa zvakaita seheparin;

d, zvigadzirwa zvekuora kwefibrinogen zvakawedzera; e, DIC.

Kupfupisa kunoonekwa mu:

Mamiriro ekuti ropa riunganidzwe zvakanyanya: Kana chinhu chinonzi procoagulant chikapinda muropa uye basa rezvinhu zvinobatanidza ropa rikawedzera, nezvimwewo:

 

4.Plasma fibrinogen (FIB)

Inonyanya kuratidza huwandu hwe fibrinogen. Plasma fibrinogen ipuroteni inosunga majoini ine huwandu hwakawanda hwezvinhu zvinosunga majoini, uye ipfungwa ye acute phase response factor.

Kuwedzera kunoonekwa mu: kutsva, chirwere cheshuga, hutachiona hwakanyanya, TB yakakomba, kenza, subacute bacterial endocarditis, pamuviri, pneumonia, cholecystitis, pericarditis, sepsis, nephrotic syndrome, uremia, acute myocardial infarction.

Kudzikira kunoonekwa mu: Congenital fibrinogen abnormality, DIC wasting hypocoagulation phase, primary fibrinolysis, hepatitis yakanyanya, liver cirrhosis.

 

5.D-Dimer (D-Dimer)

Inonyanya kuratidza basa re fibrinolysis uye chiratidzo chekuona kuvapo kana kusavapo kwe thrombosis uye fibrinolysis yechipiri mumuviri.

D-dimer chinhu chinokonzereswa nekuora kwe fibrin inobatanidza masero, iyo inowedzera muplasma mushure mekubuda kweropa, saka chiratidzo chakakosha chekuongorora thrombosis.

D-dimer yakawedzera zvakanyanya mu secondary fibrinolysis hyperactivity, asi haina kuwedzera mu primary fibrinolysis hyperactivity, inova chiratidzo chakakosha chekusiyanisa zviviri izvi.

Kuwedzera uku kunoonekwa muzvirwere zvakaita se deep vein thrombosis, pulmonary embolism, uye DIC secondary hyperfibrinolysis.