I-D-Dimer njengesalathisi sokuxela kwangaphambili izifo ezahlukeneyo:

Ngenxa yobudlelwane obusondeleyo phakathi kwenkqubo yokujiya kwegazi kunye nokuvuvukala, umonakalo we-endothelial, kunye nezinye izifo ezingezizo izifo ezifana nosulelo, utyando okanye ukwenzakala, ukusilela kwentliziyo, kunye neethumba ezinobungozi, ukwanda kwe-D-Dimer kuhlala kubonwa. Kuphando, kufunyenwe ukuba eyona nto ixhaphakileyo yokuxela kwangaphambili kwezi zifo kuseyi-thrombosis, i-DIC, njl. Uninzi lwezi ngxaki zezona zifo zixhaphakileyo okanye iimeko ezibangela ukunyuka kwe-D-Dimer. Ngoko ke i-D-Dimer ingasetyenziswa njengesalathisi sovavanyo olubanzi nolunovelwano lwezifo.

1. Kwizigulane ezinomhlaza, izifundo ezininzi zifumanise ukuba izinga lokusinda leminyaka eli-1-3 kwizigulane ezine-tumor enobungozi ezine-D-Dimer ephezulu liphantsi kakhulu kunelabo bane-D-Dimer eqhelekileyo. I-D-Dimer ingasetyenziswa njengesalathisi sokuvavanya ukubikezela kwangaphambili kwezigulane ezine-tumor enobungozi.

2. Kwizigulane ze-VTE, izifundo ezininzi ziqinisekisile ukuba izigulane ezine-D-Dimer ngexesha lokuthintela ukujiya kwegazi zinomngcipheko ophezulu ngokuphindwe ka-2-3 wokubuyela kwe-thrombotic emva koko xa kuthelekiswa nezigulane ezingezizo. Olunye uhlalutyo lwe-meta-analysis lwabathathi-nxaxheba abayi-1818 kwizifundo ezi-7 lubonise ukuba i-D-Dimer engaqhelekanga yenye yezona zinto ziphambili ezixela ukubuya kwe-thrombotic kwizigulane ze-VTE, kwaye i-D-Dimer ifakiwe kwiimodeli ezininzi zokuqikelela ukubuya kwe-VTE.

3. Kwizigulana ezifakelwa ukutshintshwa kwevalvu yomatshini (i-MHVR), uphando olulandelelanayo oluqhubeke ixesha elide lwabathathi-nxaxheba abangama-618 lubonise ukuba izigulana ezinezinga elingaqhelekanga le-D-Dimer ngexesha le-warfarin emva kwe-MHVR zazinomngcipheko weziganeko ezimbi malunga namaxesha ama-5 aphezulu kunezo zinezinga eliqhelekileyo. Uhlalutyo lwe-Multivariate correlation luqinisekisile ukuba amanqanaba e-D-Dimer ayeziimpawu ezizimeleyo ze-thrombosis okanye iziganeko zentliziyo ngexesha lokuthintela ukugabha kwegazi.

4. Kwizigulane ezine-atrial fibrillation (AF), i-D-Dimer inokuqikelela iziganeko ze-thrombotic kunye ne-cardiovascular ngexesha lokuthintela ukujiya kwegazi ngomlomo. Uphononongo olucwangcisiweyo lwezigulane ezingama-269 ezine-atrial fibrillation olulandelwe malunga neminyaka emi-2 lubonise ukuba ngexesha lokuthintela ukujiya kwegazi ngomlomo, malunga nama-23% ezigulane ezifikelele kumgangatho we-INR zibonise amanqanaba e-D-Dimer angaqhelekanga, ngelixa izigulane ezine-D-Dimer angaqhelekanga zazinomngcipheko ophezulu ngokuphindwe ka-15.8 kunye ne-7.64 weziganeko ze-thrombotic kunye ne-cardiovascular ezihambelanayo xa kuthelekiswa nezigulane ezine-D-Dimer amanqanaba aqhelekileyo, ngokwahlukeneyo.
Kwezi zifo okanye izigulane ezithile, i-D-Dimer ephezulu okanye ehlala ikho idla ngokubonisa ukuba imeko ayintlanga okanye ukuba mandundu kwesifo.