Kunokwenzeka ukwazi ukuba isigulana sinomsebenzi ongaqhelekanga wokujiya kwegazi ngaphambi kotyando, ukuze kuthintelwe ngokufanelekileyo iimeko ezingalindelekanga ezifana nokopha okungapheliyo ngexesha nasemva kotyando, ukuze kufumaneke umphumo ongcono wotyando.
Umsebenzi womzimba wokomisa igazi ufezekiswa yintshukumo edibeneyo yeeplatelets, inkqubo yokujiya kwegazi, inkqubo ye-fibrinolytic kunye nenkqubo ye-vascular endothelial. Ngaphambili, besisebenzisa ixesha lokomisa igazi njengovavanyo lokuhlola iziphene zomsebenzi we-hemostatic, kodwa ngenxa yomgangatho walo ophantsi, uvakalelo oluphantsi, kunye nokungakwazi ukubonisa umxholo kunye nomsebenzi wezinto ezijiya igazi, ithatyathelwe indawo luvavanyo lomsebenzi wokujiya kwegazi. Uvavanyo lomsebenzi wokujiya kwegazi luquka ikakhulu ixesha le-plasma prothrombin (PT) kunye nomsebenzi we-PT obalwe kwi-PT, i-international normalized ratio (INR), i-fibrinogen (FIB), ixesha le-activated partial thromboplastin (APTT) kunye nexesha le-plasma thrombin (TT).
I-PT ibonakalisa kakhulu umsebenzi wenkqubo yokujiya kwamathumbu ngaphandle. I-PT ende ibonakala kakhulu kwi-congenital coagulation factor II, V, VII, kunye ne-X reduction, i-fibrinogen deficiency, i-acquired coagulation factor deficiency (i-DIC, i-primary hyperfibrinolysis, i-obstructive jaundice, i-vitamin K deficiency, kunye nezinto ezilwa ne-coagulant ekujikelezeni kwegazi. I-PT shortening ibonwa kakhulu kwi-congenital coagulation factor V increase, i-DIC yasekuqaleni, izifo ze-thrombotic, ii-oral contraceptives, njl.njl.; ukujonga i-PT kungasetyenziswa njengokujonga amayeza e-clinical oral anticoagulant.
I-APTT lolona vavanyo luthembekileyo lokuhlola ukungabikho kwe-endogenous coagulation factor deficiency. I-APTT ende ibonwa kakhulu kwi-hemophilia, i-DIC, isifo sesibindi, kunye nokudluliselwa kwegazi okubanzi. I-APTT efinyeziweyo ibonwa kakhulu kwi-DIC, imeko ye-prothrombotic, kunye nezifo ze-thrombotic. I-APTT ingasetyenziswa njengesalathisi sokujonga unyango lwe-heparin.
Ukwandiswa kwe-TT kubonakala kwi-hypofibrinogenemia kunye ne-dysfibrinogenemia, ukwanda kwe-FDP egazini (DIC), kunye nokuba khona kwe-heparin kunye nezinto ze-heparinoid egazini (umz., ngexesha lonyango lwe-heparin, i-SLE, isifo sesibindi, njl.njl.).
Kwakukho isigulane esingxamisekileyo esafumana uvavanyo lwelabhoratri ngaphambi kotyando, kwaye iziphumo zovavanyo lokujiya zaziyi-PT kunye ne-APTT ende, kwaye i-DIC yayikrokrelwa kwisigulana. Ngaphantsi kwengcebiso yelabhoratri, isigulana senza uthotho lweemvavanyo ze-DIC kwaye iziphumo zazilungile. Akukho zimpawu zicacileyo ze-DIC. Ukuba isigulana asinalo uvavanyo lokujiya, kunye notyando oluthe ngqo, iziphumo ziya kuba zimbi kakhulu. Iingxaki ezininzi ezinjalo zinokufunyanwa kuvavanyo lomsebenzi wokujiya, oluye lwathenga ixesha elingakumbi lokufumanisa nonyango lwezifo. Uvavanyo lochungechunge lokujiya luvavanyo olubalulekileyo lwelabhoratri lomsebenzi wokujiya kwezigulane, olunokufumanisa umsebenzi wokujiya kwezigulane ongaqhelekanga ngaphambi kotyando, kwaye kufuneka lunikwe ingqalelo eyaneleyo.
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