N'zotheka kudziwa ngati wodwalayo ali ndi vuto la magazi oundana asanachite opaleshoni, kupewa bwino zinthu zosayembekezereka monga kutuluka magazi kosalekeza panthawi ya opaleshoni komanso pambuyo pake, kuti apeze zotsatira zabwino kwambiri pa opaleshoni.
Ntchito ya hemostatic ya thupi imatheka chifukwa cha kugwira ntchito kwa ma platelet, coagulation system, fibrinolytic system ndi vascular endothelial system. Kale, tinkagwiritsa ntchito nthawi yotuluka magazi ngati mayeso owunikira zolakwika za hemostatic function, koma chifukwa cha kukhazikika kwake kochepa, kusazindikira bwino, komanso kulephera kuwonetsa zomwe zili ndi ntchito ya coagulation factors, yasinthidwa ndi mayeso a coagulation function. Mayeso a coagulation function makamaka amaphatikizapo nthawi ya plasma prothrombin (PT) ndi PT activity yowerengedwa kuchokera ku PT, international normalized ratio (INR), fibrinogen (FIB), activated partial thromboplastin time (APTT) ndi plasma thrombin time (TT).
PT imasonyeza kwambiri ntchito ya extrinsic coagulation system. PT yayitali imawonekera makamaka mu congenital coagulation factor II, V, VII, ndi X reduction, fibrinogen deficiency, acquired coagulation factor deficiency (DIC, primary hyperfibrinolysis, obstructive jaundice, vitamin K deficiency, ndi anticoagulant substances in the blood circulation. Kufupikitsa kwa PT kumawonekera makamaka mu congenital coagulation factor V increase, DIC yoyambirira, matenda a thrombotic, pakamwa contraceptive, etc.; kuyang'anira PT kungagwiritsidwe ntchito ngati kuyang'anira mankhwala a pakamwa a anticoagulant.
APTT ndiye njira yodalirika kwambiri yoyezera matenda a endogenous coagulation factor deficiency. APTT yayitali imapezeka makamaka mu hemophilia, DIC, matenda a chiwindi, ndi kuikidwa magazi ambiri m'magazi. APTT yofupikitsidwa imapezeka makamaka mu DIC, prothrombotic state, ndi matenda a thrombotic. APTT ingagwiritsidwe ntchito ngati chizindikiro chowunikira chithandizo cha heparin.
Kutalikitsa nthawi ya TT kumawoneka mu hypofibrinogenemia ndi dysfibrinogenemia, kuwonjezeka kwa FDP m'magazi (DIC), komanso kupezeka kwa heparin ndi zinthu za heparinoid m'magazi (monga, panthawi ya chithandizo cha heparin, SLE, matenda a chiwindi, ndi zina zotero).
Panali wodwala wadzidzidzi amene analandira mayeso a labotale asanachite opaleshoni, ndipo zotsatira za mayeso a coagulation zinali PT ndi APTT yayitali, ndipo DIC inkaganiziridwa kuti ndi ya wodwalayo. Malinga ndi malangizo a labotale, wodwalayo anayesedwa DIC angapo ndipo zotsatira zake zinali zabwino. Palibe zizindikiro zoonekeratu za DIC. Ngati wodwalayo alibe mayeso a coagulation, komanso opaleshoni yolunjika, zotsatira zake zidzakhala zoopsa. Mavuto ambiri oterewa angapezeke kuchokera ku mayeso a coagulation function, omwe atenga nthawi yochulukirapo kuti azindikire ndi kuchiza matenda. Kuyesa kwa coagulation series ndi mayeso ofunikira a labotale a coagulation function ya odwala, omwe amatha kuzindikira coagulation function yosazolowereka mwa odwala opaleshoni isanachitike, ndipo iyenera kusamalidwa mokwanira.
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