Nws muaj peev xwm paub seb tus neeg mob puas muaj kev ua haujlwm tsis zoo ua ntej phais, tiv thaiv cov xwm txheej tsis tau xav txog xws li kev los ntshav tsis tu ncua thaum lub sijhawm thiab tom qab phais, kom tau txais txiaj ntsig zoo tshaj plaws ntawm kev phais.
Lub cev txoj kev ua haujlwm hemostatic yog ua tiav los ntawm kev sib koom tes ntawm cov platelets, coagulation system, fibrinolytic system thiab vascular endothelial system. Yav dhau los, peb siv lub sijhawm los ntshav ua kev kuaj mob rau cov teeb meem hemostatic, tab sis vim nws tsis tshua muaj tus qauv, tsis muaj kev nkag siab zoo, thiab tsis muaj peev xwm cuam tshuam cov ntsiab lus thiab kev ua haujlwm ntawm cov coagulation factors, nws tau hloov los ntawm kev kuaj mob coagulation. Kev kuaj mob coagulation feem ntau suav nrog plasma prothrombin time (PT) thiab PT activity xam los ntawm PT, international normalized ratio (INR), fibrinogen (FIB), activated partial thromboplastin time (APTT) thiab plasma thrombin time (TT).
PT feem ntau qhia txog kev ua haujlwm ntawm lub cev coagulation. PT ntev feem ntau pom hauv kev txo qis ntawm cov coagulation factor II, V, VII, thiab X, fibrinogen deficiency, acquired coagulation factor deficiency (DIC, primary hyperfibrinolysis, obstructive jaundice, vitamin K deficiency, thiab anticoagulant tshuaj hauv cov ntshav ncig. PT luv luv feem ntau pom hauv congenital coagulation factor V nce, DIC thaum ntxov, thrombotic kab mob, tshuaj tiv thaiv kab mob hauv qhov ncauj, thiab lwm yam; kev saib xyuas PT tuaj yeem siv ua kev saib xyuas cov tshuaj anticoagulant hauv qhov ncauj.
APTT yog qhov kev kuaj mob zoo tshaj plaws rau kev tsis muaj cov tshuaj coagulation factor hauv cov ntshav. APTT ntev feem ntau pom muaj nyob rau hauv cov neeg mob hemophilia, DIC, kab mob siab, thiab kev hloov ntshav ntau dhau. APTT luv luv feem ntau pom muaj nyob rau hauv DIC, lub xeev prothrombotic, thiab cov kab mob thrombotic. APTT tuaj yeem siv ua qhov ntsuas saib xyuas rau kev kho mob heparin.
Qhov ntev ntawm TT pom muaj nyob rau hauv hypofibrinogenemia thiab dysfibrinogenemia, FDP ntau ntxiv hauv cov ntshav (DIC), thiab muaj cov tshuaj heparin thiab heparinoid hauv cov ntshav (piv txwv li, thaum kho heparin, SLE, kab mob siab, thiab lwm yam).
Muaj ib zaug ib tug neeg mob ceev uas tau txais kev kuaj mob ua ntej kev phais, thiab cov txiaj ntsig ntawm kev kuaj ntshav coagulation tau ntev PT thiab APTT, thiab DIC tau raug xav tias muaj nyob rau hauv tus neeg mob. Raws li cov lus qhia ntawm lub chaw kuaj mob, tus neeg mob tau ua ntau qhov kev kuaj DIC thiab cov txiaj ntsig zoo. Tsis muaj cov tsos mob pom tseeb ntawm DIC. Yog tias tus neeg mob tsis muaj kev kuaj ntshav coagulation, thiab phais ncaj qha, cov txiaj ntsig yuav muaj kev puas tsuaj loj heev. Ntau yam teeb meem zoo li no tuaj yeem pom los ntawm kev kuaj ntshav coagulation, uas tau siv sijhawm ntau dua rau kev kuaj mob thiab kho cov kab mob. Kev kuaj ntshav coagulation yog ib qho kev kuaj mob tseem ceeb rau kev kuaj mob coagulation ntawm tus neeg mob, uas tuaj yeem kuaj pom cov haujlwm coagulation tsis zoo hauv cov neeg mob ua ntej kev phais, thiab yuav tsum tau them sai sai.
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