Isikhathi se-prothrombin (PT) siyinkomba ebaluleke kakhulu yokubonisa umsebenzi wokwenziwa kwesibindi, umsebenzi wokugcina, ubukhali besifo kanye nokubikezela. Njengamanje, ukutholakala kwezifo ezibangela ukujiya kwesibindi sekuyinto engokoqobo, futhi kuzohlinzeka ngolwazi lwangaphambilini nolunembile kakhulu kune-PT ekwahluleleni isimo sesifo sesibindi.

Ukusetshenziswa kwe-PT emtholampilo esifweni sesibindi:

Ilabhorethri ibika i-PT ngezindlela ezine: i-prothrombintime activitypercentagePTA (i-prothrombin time ratio PTR) kanye ne-international normalized ratio INR. Lezi zinhlobo ezine zinenani elihlukile lokusetshenziswa kwemitholampilo.

Inani lokusetshenziswa kwe-PT esifweni sesibindi: I-PT inqunywa kakhulu yizinga le-coagulation factor IIvX elenziwe yisibindi, futhi indima yayo esifweni sesibindi ibaluleke kakhulu. Izinga elingavamile le-PT esifweni sesibindi esibi kakhulu lalingu-10%-15%, i-hepatitis engapheli yayingu-15%-51%, i-cirrhosis yayingu-71%, kanti i-hepatitis enzima yayingu-90%. Ezindleleni zokuxilonga i-hepatitis egciwaneni ngo-2000, i-PTA ingenye yezinkomba zesigaba sezokwelapha seziguli ezine-hepatitis egciwaneni. Iziguli ezine-hepatitis egciwaneni engapheli ezine-PTA encane>70%, eziphakathi nendawo 70%-60%, ezinzima 60%-40%; i-cirrhosis ene-PTA ekhokhelwayo>60% yesigaba se-PTA esincishisiwe<60%; I-hepatitis PTA enzima<40%" Esigabeni se-Child-Pugh, iphuzu eli-1 lokwelulwa kwe-PT okungu-1 ~ 4s, amaphuzu ama-2 kumasekhondi angu-4 ~ 6, amaphuzu ama-3 kumasekhondi angu->6, kuhlanganiswe nezinye izinkomba ezi-4 (i-albumin, i-bilirubin, i-ascites, i-encephalopathy), umsebenzi wesibindi weziguli ezinesifo sesibindi. Ama-Reserves ahlukaniswe ngama-ABC grades; i-MELD score (Modelfor end-stage liver disease), enquma ubukhulu besifo ezigulini ezinesifo sesibindi sesigaba sokugcina kanye nokulandelana kokufakelwa kwesibindi, ifomula ingu-.8xloge[bilirubin(mg/dl)+11.2xloge(INR)+9.6xloge[creatinine (mg/dl]+6.4x (imbangela: i-biliary noma i-alcohol 0; enye i-1), i-INR ingenye yezinkomba ezi-3.

Izindlela zokuxilonga ze-DIC zesifo sesibindi zifaka: Ukwandiswa kwe-PT isikhathi esingaphezu kwamasekhondi angu-5 noma isikhathi se-activated partial thromboplastin (APTT) isikhathi esingaphezu kwamasekhondi angu-10, umsebenzi we-factor VIII <50% (kuyadingeka); i-PT kanye nenani lama-platelet kuvame ukusetshenziselwa ukuhlola i-biopsy yesibindi kanye nokuhlinzwa. Ukuthambekela kokopha kweziguli, njenge-platelet <50x10°/L, kanye nokwandiswa kwe-PT okudlula okuvamile kwamasekhondi angu-4 kuyizinto ezingahambisani ne-biopsy yesibindi kanye nokuhlinzwa okuhlanganisa nokufakelwa kwesibindi. Kungabonakala ukuthi i-PT idlala indima ebalulekile ekuxilongweni nasekwelapheni iziguli ezinesifo sesibindi.