ʻO ka manawa Prothrombin (PT) kahi hōʻailona koʻikoʻi e hōʻike i ka hana o ka ate synthesis, ka hana mālama, ka nui o ka maʻi a me ka prognosis.I kēia manawa, ua lilo ka ʻike lapaʻau o nā kumu coagulation i mea ʻoiaʻiʻo, a hāʻawi ia i ka ʻike ma mua a ʻoi aku ka pololei ma mua o ka PT i ka hoʻoholo ʻana i ke ʻano o ka maʻi ate.

ʻO ka noi ʻana o ka PT i ka maʻi ate:

Hōʻike ka hale hana i ka PT ma nā ʻano ʻehā: prothrombintime activitypercentagePTA (prothrombin time ratio PTR) a me INR normalized ratio honua.Loaʻa i nā ʻano ʻehā nā waiwai hoʻohana lapaʻau like ʻole.

ʻO ka waiwai noi o PT i ka maʻi ate: Hoʻoholo nui ʻia ʻo PT e ke kiʻekiʻe o ka coagulation factor IIvX synthesized e ke ake, a he mea koʻikoʻi kona kuleana i ka maʻi ate.He 10% -15% ka helu ma'amau o ka PT ma ka ma'i hepa nui, he 15%-51% ka ma'i hepatitis, he 71% ka cirrhosis, a he 90% ka ma'i hepa nui.Ma nā pae hoʻohālikelike o ka maʻi hepatitis viral i ka makahiki 2000, ʻo PTA kekahi o nā hōʻailona o ka hoʻonohonoho ʻana i nā maʻi me ka maʻi hepatitis viral.ʻO nā maʻi maʻi hepatitis viral maʻi me ka PTA māmā> 70%, 70% -60% kūpono, 60% -40% koʻikoʻi;cirrhosis me ka pae uku PTA>60% decompensated stage PTA<60%;ʻO ka maʻi hepatitis koʻikoʻi PTA<40%" Ma ka hoʻohālikelike ʻana o Child-Pugh, 1 helu no ka hoʻolōʻihi ʻana o PT o 1 ~ 4s, 2 mau helu no 4 ~ 6s, 3 mau helu no>6s, hui pū ʻia me nā hōʻailona 4 ʻē aʻe (albumin, bilirubin, ascites, encephalopathy ), ka hana o ka ate o ka poe ma'i me ka ma'i akepa'a Ua maheleia na waihona i na papa ABC; MELD score (Modelfor end-stageliver disease), ka mea e ho'oholo ai i ke ko'iko'i o ka ma'i i loko o ka po'e ma'i me ka ma'i ate hope a me ke ka'ina o ka ho'ololi o ke ake, ka ʻO ka formula .8xloge[bilirubin(mg/dl)+11.2xloge(INR)+ 9.6xloge[creatinine (mg/dl]+6.4x (ke kumu: biliary a i ʻole alcoholic 0; ʻē aʻe 1), ʻo INR kekahi o 3 mau hōʻailona.

ʻO nā pae hoʻohālikelike DIC no ka maʻi ate: ʻO ka hoʻolōʻihi ʻana o PT no ka ʻoi aku ma mua o 5s a i ʻole ka manawa thromboplastin ʻāpana i hoʻāla ʻia (APTT) no ka ʻoi aku ma mua o 10s, ka hana helu VIII <50% (pono);Hoʻohana pinepine ʻia ka PT a me ka helu platelet no ka loiloi ʻana i ka biopsy ate a me ke ʻoki ʻana ʻO ke ʻano o ke koko o nā maʻi, e like me nā platelets <50x10°/L, a me ka hoʻolōʻihi ʻana o PT ma mua o ka maʻamau no nā 4s he contraindications no ka biopsy ate a me ke ʻoki ʻana me ka hoʻololi ʻana i ka ate.Hiki ke ʻike ʻia he kuleana koʻikoʻi ka PT i ka ʻike a me ka mālama ʻana i nā maʻi me ka maʻi ate.