Ixesha le-Prothrombin (PT) liyimpawu ebaluleke kakhulu yokubonisa umsebenzi wokwenziwa kwesibindi, umsebenzi ogciniweyo, ubunzima besifo kunye nokubikezela kwangaphambili. Okwangoku, ukufunyanwa kwezonyango kwezinto ezibangela ukujiya kwegazi kuye kwaba yinyani, kwaye kuya kubonelela ngolwazi lwangaphambili noluchanekileyo kune-PT ekugwebeni imeko yesifo sesibindi.

Ukusetyenziswa kweklinikhi kwe-PT kwisifo sesibindi:

Ilebhu ibika i-PT ngeendlela ezine: ipesenti yomsebenzi we-prothrombintimePTA (i-prothrombin time ratio PTR) kunye ne-international normalized ratio INR. Ezi fom zine zinexabiso ezahlukeneyo zesicelo seklinikhi.

Ixabiso lokusetyenziswa kwe-PT kwisifo sesibindi: I-PT ixhomekeke kakhulu kwinqanaba le-coagulation factor IIvX eyenziwe sisibindi, kwaye indima yayo kwisifo sesibindi ibaluleke kakhulu. Izinga elingaqhelekanga le-PT kwi-hepatitis ebukhali yayiyi-10%-15%, i-hepatitis engapheliyo yayiyi-15%-51%, i-cirrhosis yayiyi-71%, kwaye i-hepatitis enzima yayiyi-90%. Kwiikhrayitheriya zokuxilonga i-hepatitis yentsholongwane ngo-2000, i-PTA yenye yeempawu zokubekwa kwezigulane ezine-hepatitis yentsholongwane. Izigulane ezine-hepatitis yentsholongwane engapheliyo ezine-PTA encinci>70%, eziphakathi kwe-70%-60%, ezinzima yi-60%-40%; i-cirrhosis ene-PTA ehlawulelweyo>60% ye-PTA ehlawulelweyo<60%; I-hepatitis PTA enzima<40%" Kuhlelo lwe-Child-Pugh, inqaku eli-1 lokwandiswa kwe-PT ye-1 ~ 4s, amanqaku ama-2 kwi-4 ~ 6s, amanqaku ama-3 kwi->6s, kunye nezinye izalathisi ezi-4 (i-albumin, i-bilirubin, i-ascites, i-encephalopathy), umsebenzi wesibindi wezigulane ezinesifo sesibindi. I-Reserves yahlulwe yaba ngamanqanaba e-ABC; amanqaku e-MELD (Imodeli yesifo sesibindi sokugqibela), emisela ubunzima besifo kwizigulane ezinesifo sesibindi sokugqibela kunye nolandelelwano lokufakelwa kwesibindi, ifomula yi-.8xloge[bilirubin(mg/dl)+11.2xloge(INR)+9.6xloge[creatinine (mg/dl]+6.4x (imbangela: i-biliary okanye i-alcohol 0; enye i-1), i-INR yenye yezalathisi ezi-3.

Iindlela zokuxilongwa ze-DIC zesifo sesibindi ziquka: Ukwandiswa kwe-PT ngaphezu kwemizuzwana emi-5 okanye ixesha le-activated partial thromboplastin (APTT) ngaphezulu kwemizuzwana eli-10, umsebenzi we-factor VIII <50% (efunekayo); I-PT kunye ne-platelet count zihlala zisetyenziselwa ukuvavanya i-liver biopsy kunye notyando. Ukuthambekela kokopha kwezigulane, ezifana nee-platelet <50x10°/L, kunye nokwandiswa kwe-PT okugqitha okuqhelekileyo kwimizuzu emi-4 ziingxaki zokufakelwa kwesibindi kunye notyando kubandakanya ukufakelwa kwesibindi. Kuyabonakala ukuba i-PT idlala indima ebalulekileyo ekuxilongweni nasekunyangweni kwezigulane ezinesifo sesibindi.