Nguva yeprothrombin (PT) chiratidzo chakakosha chekuratidza mashandiro ekugadzira chiropa, mashandiro ekuchengetedza, kuoma kwechirwere uye fungidziro yekufanotaura. Parizvino, kuongororwa kwekiriniki kwezvinhu zvinokonzera kuvharika kweropa kwave kwechokwadi, uye kuchapa ruzivo rwekare uye rwakarurama kupfuura PT mukutonga mamiriro echirwere chechiropa.

Kushandiswa kwePT mukurapa chirwere chechiropa:

Rabhoritari inoshuma PT nenzira ina: prothrombintime activitypercentagePTA (prothrombin time ratio PTR) uye international normalized ratio INR. Mafomu mana aya ane maitiro akasiyana ekiriniki.

Kukosha kwekushandiswa kwePT muchirwere chechiropa: PT inonyanya kutsanangurwa nehuwandu hwe coagulation factor IIvX inogadzirwa nechiropa, uye basa rayo muchirwere chechiropa rakakosha zvikuru. Mwero wePT muchirwere chehepatitis chakakomba waive 10%-15%, hepatitis isingaperi yaive 15%-51%, cirrhosis yaive 71%, uye hepatitis yakakomba yaive 90%. Mukuongorora chirwere chehepatitis chakakomba muna 2000, PTA ndeimwe yezviratidzo zvekurapa kwevarwere vane hepatitis yakakomba. Varwere vane hepatitis yakakomba vane PTA isina kusimba>70%, vari pakati nepakati 70%-60%, vakakomba 60%-40%; cirrhosis ine PTA yakabhadharwa>60% decompensated stage PTA<60%; Chiropa chakakomba chehepatitis PTA<40%" Muchikamu cheChild-Pugh, poindi imwe chete yekuwedzera kwePT kwe1 ~ 4s, mapoinzi maviri e4 ~ 6s, mapoinzi matatu e > 6s, pamwe chete nezvimwe zviratidzo zvina (albumin, bilirubin, ascites, encephalopathy), mashandiro echiropa evarwere vane chirwere chechiropa. Nzvimbo dzakachengetwa dzakakamurwa kuita mamakisi eABC; MELD score (Modelfor end-stageliver disease), iyo inosarudza kuoma kwechirwere muvarwere vane chirwere chechiropa chekupedzisira uye kutevedzana kwekuisirwa kwechiropa, fomura yacho ndeye .8xloge[bilirubin(mg/dl)+11.2xloge(INR)+ 9.6xloge[creatinine (mg/dl]+6.4x (chikonzero: nyongo kana doro 0; imwe 1), INR ndeimwe yezviratidzo zvitatu.

Nzira dzekuongorora chirwere chechiropa dzinoti: Kuwedzerwa kwePT kweanopfuura 5s kana activated partial thromboplastin time (APTT) kweanopfuura 10s, factor VIII activity <50% (inodiwa); PT uye platelet count zvinowanzo shandiswa kuongorora liver biopsy nekuvhiyiwa. Kubuda ropa kwevarwere, senge maplatelet <50x10°/L, uye kuwedzerwa kwePT kupfuura zvakajairika kwe4s zvinorambidzwa pakuongorora liver biopsy nekuvhiyiwa kusanganisira kuisirwa chiropa. Zvinogona kuonekwa kuti PT ine basa rakakosha mukuongorora nekurapa varwere vane chirwere chechiropa.