Nthawi ya prothrombin (PT) ndi chizindikiro chofunikira kwambiri chowonetsa momwe chiwindi chimagwirira ntchito, momwe chimagwirira ntchito, kuopsa kwa matenda komanso nthawi yomwe chimachitika. Pakadali pano, kuzindikira kwa matenda otsekeka kwakhala koona, ndipo kudzapereka chidziwitso choyambirira komanso cholondola kuposa PT poyesa momwe matenda a chiwindi alili.

Kugwiritsa ntchito PT kuchipatala pa matenda a chiwindi:

Laboratory imapereka lipoti la PT m'njira zinayi: prothrombintime activitypercentagePTA (prothrombin time ratio PTR) ndi international normalized ratio INR. Mafomu anayiwa ali ndi ma values ​​osiyanasiyana ogwiritsira ntchito kuchipatala.

Kufunika kwa PT pa matenda a chiwindi: PT imadalira kwambiri kuchuluka kwa coagulation factor IIvX komwe kumapangidwa ndi chiwindi, ndipo ntchito yake pa matenda a chiwindi ndi yofunika kwambiri. Kuchuluka kwa PT mu matenda a chiwindi oopsa kunali 10%-15%, matenda a chiwindi osatha anali 15%-51%, matenda a chiwindi anali 71%, ndipo matenda a chiwindi oopsa anali 90%. Mu njira zodziwira matenda a chiwindi mu 2000, PTA ndi chimodzi mwa zizindikiro za matenda a chiwindi omwe odwala ali ndi matenda a chiwindi. Odwala matenda a chiwindi osatha omwe ali ndi PTA yofatsa>70%, apakati 70%-60%, oopsa 60%-40%; matenda a chiwindi omwe ali ndi PTA yolipidwa>60% siteji yochepetsedwa ya PTA<60%; Matenda a chiwindi oopsa a PTA<40%" Mu gulu la Child-Pugh, mfundo imodzi pa PT yotalikitsa 1 ~ 4s, mfundo ziwiri pa 4 ~ 6s, mfundo zitatu pa > 6s, kuphatikiza ndi zizindikiro zina 4 (albumin, bilirubin, ascites, encephalopathy), ntchito ya chiwindi ya odwala omwe ali ndi matenda a chiwindi. Malo osungira amagawidwa m'magulu a ABC; MELD score (Modelfor end-stage liver disease), yomwe imatsimikizira kuopsa kwa matendawa mwa odwala omwe ali ndi matenda a chiwindi omwe ali kumapeto kwa siteji komanso kutsata kwa kuikidwa kwa chiwindi, fomula ndi .8xloge[bilirubin(mg/dl)+11.2xloge(INR)+9.6xloge[creatinine (mg/dl]+6.4x (chifukwa: biliary kapena alcoholic 0; ina 1), INR ndi imodzi mwa zizindikiro zitatu.

Njira zodziwira matenda a chiwindi (DIC) ndi monga: Kutalikitsa nthawi ya PT kwa masekondi opitilira 5 kapena nthawi yogwira ntchito ya thromboplastin (APTT) kwa masekondi opitilira 10, ntchito ya factor VIII <50% (yofunikira); PT ndi kuchuluka kwa ma platelet nthawi zambiri zimagwiritsidwa ntchito poyesa biopsy ya chiwindi ndi opaleshoni. Kuchuluka kwa magazi m'magazi kwa odwala, monga ma platelet <50x10°/L, ndi kutalika kwa PT kopitilira muyezo kwa masekondi 4 ndi zotsutsana ndi biopsy ya chiwindi ndi opaleshoni kuphatikizapo kupatsa chiwindi. Zitha kuwoneka kuti PT imagwira ntchito yofunika kwambiri pakuzindikira ndi kuchiza odwala omwe ali ndi matenda a chiwindi.