He mea nui loa ka manawa Prothrombin (PT) e hōʻike i ka hana synthesis o ke akepaʻa, ka hana mālama, ke koʻikoʻi o ka maʻi a me ka wānana. I kēia manawa, ua lilo ka ʻike lapaʻau o nā mea coagulation i mea maoli, a e hāʻawi ia i ka ʻike mua a pololei hoʻi ma mua o ka PT i ka hoʻoholo ʻana i ke kūlana o ka maʻi akepaʻa.

Ka hoʻohana lapaʻau ʻana o PT i nā maʻi akepaʻa:

Hōʻike ka hale hana hoʻokolohua iā PT ma nā ʻano ʻehā: prothrombintime activitypercentagePTA (prothrombin time ratio PTR) a me ka international normalized ratio INR. Loaʻa i nā ʻano ʻehā nā waiwai noi lapaʻau like ʻole.

ʻO ka waiwai noi o PT i ka maʻi akepaʻa: Hoʻoholo nui ʻia ka PT e ka pae o ka coagulation factor IIvX i hana ʻia e ke akepaʻa, a he mea nui loa kona kuleana i ka maʻi akepaʻa. ʻO ka nui maʻamau ʻole o PT i ka hepatitis koʻikoʻi he 10%-15%, ʻo ka hepatitis mau loa he 15%-51%, ʻo ka cirrhosis he 71%, a ʻo ka hepatitis koʻikoʻi he 90%. I loko o nā pae hoʻohālikelike o ka hepatitis viral i ka makahiki 2000, ʻo ka PTA kekahi o nā hōʻailona o ke kahua lapaʻau o nā maʻi me ka hepatitis viral. ʻO nā maʻi hepatitis viral mau loa me ka PTA akahai>70%, waena 70%-60%, koʻikoʻi 60%-40%; cirrhosis me ke kahua compensated PTA>60% decompensated stage PTA<60%; hepatitis koʻikoʻi PTA<40%" Ma ka hoʻokaʻawale ʻana o Child-Pugh, 1 helu no ka hoʻolōʻihi ʻana o PT o 1~4s, 2 helu no 4~6s, 3 helu no >6s, i hui pū ʻia me nā ʻōkuhi 4 ʻē aʻe (albumin, bilirubin, ascites, encephalopathy), ua māhele ʻia ka hana ate o nā maʻi me ka maʻi ate. Ua māhele ʻia nā waihona i nā māka ABC; helu MELD (Modelfor end-stage liver disease), ka mea e hoʻoholo ai i ke koʻikoʻi o ka maʻi i nā maʻi me ka maʻi ate hope loa a me ke kaʻina o ka hoʻoili ʻana o ke ate, ʻo ke ʻano he .8xloge[bilirubin(mg/dl)+11.2xloge(INR)+ 9.6xloge[creatinine (mg/dl]+6.4x (kumu: biliary a i ʻole ka mea ʻona 0; ʻē aʻe 1), ʻo INR kekahi o 3 mau ʻōkuhi.

ʻO nā pae hoʻohālikelike DIC no ka maʻi akepaʻa e komo pū ana me: ka hoʻolōʻihi ʻana o ka PT no nā mea he 5 kekona a i ʻole ka manawa thromboplastin hapa i hoʻāla ʻia (APTT) no nā mea he 10 kekona, ka hana factor VIII <50% (koi ʻia); Hoʻohana pinepine ʻia ka PT a me ka helu platelet e loiloi i ka biopsy akepaʻa a me ke ʻoki ʻana. ʻO ke ʻano kahe koko o nā maʻi, e like me nā platelets <50x10°/L, a me ka hoʻolōʻihi ʻana o ka PT ma mua o ka maʻamau no 4 kekona, he mau contraindications ia no ka biopsy akepaʻa a me ke ʻoki ʻana me ka hoʻoili ʻana i ke akepaʻa. Hiki ke ʻike ʻia he kuleana koʻikoʻi ka PT i ka ʻike ʻana a me ka mālama ʻana i nā maʻi me ka maʻi akepaʻa.