Lokacin Prothrombin (PT) muhimmin ma'auni ne don nuna aikin haɗa hanta, aikin ajiyar abinci, tsananin cutar da kuma hasashenta. A halin yanzu, gano abubuwan da ke haifar da coagulation a asibiti ya zama gaskiya, kuma zai samar da bayanai da suka fi PT inganci wajen tantance yanayin cutar hanta.

Amfani da PT na asibiti a cikin cututtukan hanta:

Dakin gwaje-gwaje yana ba da rahoton PT ta hanyoyi huɗu: kashi na aikin prothrombintime (rabowar lokaci na prothrombin PTR) da rabon INR na ƙasa da ƙasa. Siffofin guda huɗu suna da ƙimar aikace-aikacen asibiti daban-daban.

Darajar amfani da PT a cikin cututtukan hanta: Ana tantance PT galibi ta hanyar matakin sinadarin coagulation na IIvX da hanta ta haɗa, kuma rawar da take takawa a cikin cututtukan hanta tana da matuƙar muhimmanci. Matsakaicin ƙimar PT a cikin cutar hepatitis mai tsanani shine 10%-15%, hepatitis na yau da kullun shine 15%-51%, cirrhosis shine 71%, kuma babban hepatitis shine 90%. A cikin sharuɗɗan ganewar cutar hepatitis ta hanyar ƙwayoyin cuta a cikin 2000, PTA yana ɗaya daga cikin alamun tantancewa na asibiti na marasa lafiya da cutar hepatitis ta hanyar ƙwayoyin cuta. Marasa lafiya da ke fama da cutar hepatitis ta hanyar ƙwayoyin cuta na tsawon lokaci tare da PTA mai sauƙi>70%, matsakaici 70%-60%, mai tsanani 60%-40%; cirrhosis tare da matakin PTA mai rama>60% matakin decompensated PTA <60%; Ciwon hanta mai tsanani PTA <40%" A cikin rarrabuwar Child-Pugh, maki 1 don tsawaita PT na 1 ~ 4s, maki 2 don 4 ~ 6s, maki 3 don > 6s, tare da wasu alamomi 4 (albumin, bilirubin, ascites, encephalopathy), aikin hanta na marasa lafiya da cutar hanta An raba ajiyar zuwa maki na ABC; maki MELD (Model don cutar hanta ta ƙarshe), wanda ke ƙayyade tsananin cutar a cikin marasa lafiya da cutar hanta ta ƙarshe da kuma jerin dashen hanta, dabarar ita ce .8xloge[bilirubin(mg/dl)+11.2xloge(INR)+ 9.6xloge[creatinine (mg/dl]+6.4x (dalilin: biliary ko giya 0; sauran 1), INR ɗaya ne daga cikin alamomi 3.

Sharuɗɗan ganewar cutar hanta na DIC sun haɗa da: Tsawaita PT na fiye da sa'o'i 5 ko lokacin thromboplastin mai aiki (APTT) na fiye da sa'o'i 10, aikin factor VIII <50% (ana buƙata); Ana amfani da PT da ƙididdigar platelet sau da yawa don tantance biopsy na hanta da tiyata. Yanayin zubar jini na marasa lafiya, kamar platelets <50x10°/L, da tsawaita PT fiye da yadda aka saba na sa'o'i 4 sune abubuwan da ke hana yin biopsy na hanta da tiyata gami da dashen hanta. Ana iya ganin cewa PT tana taka muhimmiyar rawa wajen gano da kuma magance marasa lafiya da ke fama da cutar hanta.