Ekukhulelweni okuvamile, ukuphuma kwenhliziyo kuyanda futhi ukumelana kwemithambo yegazi kwehla ngokwanda kweminyaka yokukhulelwa. Ngokuvamile kukholelwa ukuthi ukuphuma kwenhliziyo kuqala ukwanda emavikini angu-8 kuya kwangu-10 okukhulelwa, futhi kufinyelela esicongweni emavikini angu-32 kuya kwangu-34 okukhulelwa, okuphakeme ngo-30% kuya ku-45% kunalapho umuntu engakhulelwe, futhi kugcina leli zinga kuze kube yilapho ebeletha. Ukwehla kokumelana kwemithambo yegazi yegazi kunciphisa umfutho wegazi, kanti umfutho wegazi we-diastolic wehla kakhulu, kanti umehluko womfutho wegazi uyakhula. Kusukela emavikini angu-6 kuya kwangu-10 okukhulelwa, umthamo wegazi labesifazane abakhulelwe uyanda ngokwanda kweminyaka yokukhulelwa, futhi ukhuphuka cishe ngo-40% ekupheleni kokukhulelwa, kodwa ukwanda komthamo wegazi kudlula kakhulu inani lamaseli abomvu egazi, i-plasma iyanda ngo-40% kuya ku-50%, kanti amaseli abomvu egazi ayanda ngo-10% kuya ku-15%. Ngakho-ke, ekukhulelweni okuvamile, igazi liyancishiswa, libonakala njengokuncipha kwe-viscosity yegazi, ukwehla kwe-hematocrit, kanye nokwanda kwesilinganiso se-erythrocyte sedimentation [1].

Izici zokujiya kwegazi Ⅱ, Ⅴ, VII, Ⅷ, IX, kanye Ⅹ zonke ziyanda ngesikhathi sokukhulelwa, futhi zingafinyelela izikhathi eziyi-1.5 kuya kwezingu-2.0 zokujwayelekile phakathi nokukhulelwa okuphakathi nokwephuzile, kanye nemisebenzi yezinto zokujiya Ⅺ kanye  yehla. I-Fibrinopeptide A, i-fibrinopeptide B, i-thrombinogen, i-platelet factor Ⅳ kanye ne-fibrinogen yanda kakhulu, kuyilapho i-antithrombin Ⅲ kanye ne-protein C kanye ne-protein S yehla. Ngesikhathi sokukhulelwa, isikhathi se-prothrombin kanye nesikhathi se-prothrombin esingaphelele esisebenzayo sifinyezwa, futhi okuqukethwe kwe-plasma fibrinogen kwanda kakhulu, okunganda kufike ku-4-6 g/L ku-trimester yesithathu, okungaphezu kuka-50% kunalokho esikhathini sokungakhulelwe. Ngaphezu kwalokho, i-plasminogen yanda, isikhathi sokuncibilika kwe-euglobulin sandiswa, futhi izinguquko zokujiya kanye nokujiya zenza umzimba ube sesimweni sokujiya okukhulu, okwakuzuzisa ekujiya okuphumelelayo ngemva kokuphazamiseka kwe-placenta ngesikhathi sokubeletha. Ngaphezu kwalokho, ezinye izici ezibangela ukujiya kwegazi ngesikhathi sokukhulelwa zifaka phakathi ukwanda kwe-cholesterol iyonke, ama-phospholipid kanye nama-triacylglycerols egazini, i-androgen kanye ne-progesterone ekhishwa yi-placenta kunciphisa umphumela wezinye izithiyo zokujiya kwegazi, i-placenta, i-uterine decidua kanye nama-embryo. Ukuba khona kwezinto ezibangela i-thromboplastin, njll., kungakhuthaza igazi ukuba libe sesimweni sokujiya kwegazi, futhi lolu shintsho luyanda ngokwanda kweminyaka yokukhulelwa. I-hypercoagulation ephakathi nendawo iyisilinganiso sokuvikela ngokomzimba, esizuzisa ukugcina ukufakwa kwe-fibrin emithanjeni, odongeni lwesibeletho kanye ne-placental villi, kusiza ukugcina ubuqotho be-placenta futhi kwakha i-thrombus ngenxa yokususwa, futhi kusiza i-hemostasis esheshayo ngesikhathi nangemva kokubeletha. , kuyindlela ebalulekile yokuvimbela ukuphuma kwegazi ngemva kokubeletha. Ngesikhathi esifanayo sokujiya kwegazi, umsebenzi wesibili we-fibrinolytic uqala futhi ukususa i-thrombus emithanjeni ye-spiral yesibeletho kanye ne-venous sinuses futhi kusheshiswe ukuvuselelwa nokulungiswa kwe-endometrium [2].

Kodwa-ke, isimo sokujiya kwegazi ngokweqile singadala nezinkinga eziningi zokubeletha. Eminyakeni yamuva nje, izifundo zithole ukuthi abesifazane abaningi abakhulelwe bathambekele ekushayweni yi-thrombosis. Lesi simo sesifo se-thromboembolism kwabesifazane abakhulelwe ngenxa yokukhubazeka kwezakhi zofuzo noma izici eziyingozi ezitholakale njengeprotheyini ye-anticoagulant, izici ze-coagulation, kanye namaprotheni e-fibrinolytic sibizwa ngokuthi i-thrombosis. (thrombophilia), eyaziwa nangokuthi isimo se-prothrombotic. Lesi simo se-prothrombotic asiholeli esifweni se-thrombotic, kodwa singaholela emiphumeleni emibi yokukhulelwa ngenxa yokungalingani kwezindlela ze-coagulation-anticoagulation noma umsebenzi we-fibrinolytic, i-microthrombosis yemithambo ye-spiral yesibeletho noma i-villus, okuholela ekungeneni kabi kwe-placental noma ngisho ne-infarction, njenge-Preeclampsia, ukuphazamiseka kwe-placental, i-placental infarction, i-disseminated intravascular coagulation (DIC), ukuvinjelwa kokukhula kwengane, ukuphuphuma kwesisu okuphindaphindiwe, ukuzalwa kwengane eshonile kanye nokuzalwa ngaphambi kwesikhathi, njll., kungaholela ekufeni komama kanye nokubeletha ezimweni ezimbi kakhulu.