Kukukhulelwa okuqhelekileyo, ukuphuma kwentliziyo kuyenyuka kwaye ukuxhathisa kwe-peripheral kuncipha ngokunyuka kwexesha lokumitha.Ngokuqhelekileyo kukholelwa ukuba imveliso yentliziyo iqala ukunyuka kwiiveki ezisi-8 ukuya kwezili-10 zokukhulelwa, kwaye ifikelela kwincopho yeeveki ezingama-32 ukuya kwezingama-34 zokukhulelwa, ezingama-30% ukuya kuma-45% aphezulu kunoko ungakhulelwanga, kwaye igcina eli nqanaba de ukuhanjiswa.Ukuncipha kokunganyangeki kwemithambo yemithambo kunciphisa uxinzelelo lwemithambo, kwaye uxinzelelo lwegazi lwe-diastolic lwehla kakhulu, kwaye umahluko woxinzelelo lwe-pulse uyanda.Ukusukela kwiiveki ezi-6 ukuya kwezili-10 zokumitha, umthamo wegazi labasetyhini abakhulelweyo uyanda ngokwanda kwexesha lokumitha, kwaye unyuka malunga ne-40% ekupheleni kokukhulelwa, kodwa ukwanda komthamo we-plasma kudlula kakhulu inani leeseli ezibomvu zegazi, iplasma. inyuka nge-40% ukuya kwi-50%, kwaye iiseli ezibomvu zegazi zonyuka nge-10% ukuya kwi-15%.Ngoko ke, ekukhulelweni okuqhelekileyo, igazi liyahlanjululwa, libonakaliswe njengokuncipha kwe-viscosity yegazi, ukunciphisa i-hematocrit, kunye nokwanda kwe-erythrocyte sedimentation rate [1].

Imiba ye-blood coagulation Ⅱ, Ⅴ, VII, Ⅷ, IX, kunye ne-Ⅹ yonke inyuka ngexesha lokukhulelwa, kwaye inokufikelela kwi-1.5 ukuya ku-2.0 amaxesha aqhelekileyo phakathi nokukhulelwa kwexesha eliphakathi, kunye nemisebenzi ye-coagulation factor Ⅺ kunye ne- iyancipha.I-Fibrinopeptide A, i-fibrinopeptide B, i-thrombinogen, i-platelet factor Ⅳ kunye ne-fibrinogen yanda kakhulu, ngelixa i-antithrombin Ⅲ kunye neprotheni C kunye neprotheni S yehla.Ngexesha lokukhulelwa, ixesha le-prothrombin kunye nexesha elisebenzayo leprothrombin lifutshane, kwaye umxholo we-plasma fibrinogen uyanda kakhulu, onokunyuka ukuya kwi-4-6 g / L kwi-trimester yesithathu, malunga ne-50% ephezulu kunomntu ongakhulelwanga. ixesha.Ukongezelela, i-plasminogen yanda, ixesha lokuchithwa kwe-euglobulin lahlala ixesha elide, kwaye utshintsho lwe-coagulation-anticoagulation lwenze umzimba kwi-hypercoagulable state, eyayinenzuzo kwi-hemostasis esebenzayo emva kokuphazamiseka kwe-placenta ngexesha lomsebenzi.Ukongezelela, ezinye izinto ezibangelwa yi-hypercoagulable ngexesha lokukhulelwa ziquka ukunyuka kwe-cholesterol epheleleyo, i-phospholipids kunye ne-triacylglycerols egazini, i-androgen kunye ne-progesterone efihliweyo yi-placenta inciphisa umphumo we-blood coagulation inhibitors, i-placenta, i-uterine decidua kunye ne-embryos.Ubukho bezinto ze-thromboplastin, njl., zinokukhuthaza igazi ukuba libe kwimeko ye-hypercoagulable, kwaye olu tshintsho lugqithiswa ngokunyuka kwexesha lokukhulelwa.I-hypercoagulation ephakathi yindlela yokukhusela i-physiological , enenzuzo yokugcina i-fibrin deposition kwi-arteries, udonga lwesibeleko kunye ne-placental villi, inceda ukugcina ingqibelelo ye-placenta kunye nefom ye-thrombus ngenxa yokuhluthwa, kunye nokuququzelela i-hemostasis ngokukhawuleza ngexesha nangemva kokunikezelwa., yindlela ebalulekileyo yokuthintela ukuphuma kwegazi emva kokubeleka.Kwangelo xesha linye, umsebenzi we-fibrinolytic wesibini uqalisa kwakhona ukususa i-thrombus kwi-uterine spiral arteries kunye ne-venous sinuses kunye nokukhawulezisa ukuvuselelwa kunye nokulungiswa kwe-endometrium [2].

Nangona kunjalo, imeko ye-hypercoagulable inokubangela iingxaki ezininzi zokubeleka.Kwiminyaka yakutshanje, uphando luye lwafumanisa ukuba abafazi abaninzi abakhulelweyo banomdla kwi-thrombosis.Esi sifo se-thromboembolism kwabasetyhini abakhulelweyo ngenxa yeziphene zemfuza okanye izinto ezinobungozi ezifunyenweyo ezifana ne-anticoagulant proteins, i-coagulation factor, kunye ne-fibrinolytic proteins kuthiwa yi-thrombosis.(thrombophilia), ekwabizwa ngokuba yimeko yeprothrombotic.Le meko ye-prothrombotic ayifuni ukukhokelela kwisifo se-thrombotic, kodwa inokukhokelela kwiziphumo ezibi zokukhulelwa ngenxa yokungalingani kwiindlela ze-coagulation-anticoagulation okanye umsebenzi we-fibrinolytic, i-microthrombosis ye-uterine spiral arteries okanye i-villus, ekhokelela kwi-placental perfusion okanye i-infarction, njenge-Preeclampsia. , i-placental abruption, i-placental infarction, i-intravascular coagulation (i-DIC) isasazwa, uthintelo lokukhula komntwana, ukuphuphuma kwesisu okuphindaphindiweyo, ukuzalwa komntwana kunye nokuzalwa kwangaphambi kwexesha, njl., kunokukhokelela ekufeni komama kunye nomntwana kwiimeko ezinzima.