01. Kudziwana koyamba ndi D-dimer, FDP

1. FDP ndilo liwu lachidziwitso lazinthu zosiyanasiyana zowonongeka za fibrin ndi fibrinogen pansi pa zochita za plasmin, zomwe makamaka zimasonyeza kuchuluka kwa thupi lonse la fibrinolytic;

2. D-dimer ndi chinthu chowonongeka cha fibrin yolumikizana ndi mtanda pansi pa zochita za plasmin, ndipo kuwonjezeka kwa msinkhu wake kumasonyeza kukhalapo kwa hyperfibrinolysis yachiwiri;

02. Kugwiritsa ntchito kuchipatala kwa D-dimer ndi FDP

Kupatula venous thrombosis (VTE imaphatikizapo DVT, PE)

Kulondola kwa D-dimer kuchotsedwa kwa deep vein thrombosis (DVT) kumatha kufika 98% -100%

Kuzindikira kwa D-dimer kungagwiritsidwe ntchito kuletsa venous thrombosis

♦Kufunika kwa kuzindikira kwa DIC

1. DIC ndi zovuta pathophysiological ndondomeko ndi kwambiri anapeza matenda thrombo-hemorrhagic syndrome.Ma DIC ambiri amayamba msanga, matenda ovuta, kukula msanga, kuzindikira zovuta, komanso kuneneratu koopsa.Ngati sanazindikire msanga ndi kulandira chithandizo moyenera, Nthawi zambiri kuyika moyo wa wodwalayo pachiswe;

2. D-dimer ikhoza kusonyeza kuopsa kwa DIC pamlingo wina, FDP ikhoza kugwiritsidwa ntchito kuyang'anira chitukuko cha matendawa pambuyo potsimikiziridwa, ndipo antithrombin (AT) imathandiza kumvetsetsa kuopsa kwa matendawa ndi mphamvu ya matendawa. Chithandizo cha heparin Kuphatikiza kwa kuyezetsa kwa D-dimer, FDP ndi AT kwakhala chizindikiro chabwino kwambiri chodziwira DIC.

♦Kufunika kwa zotupa zoopsa

1. Zotupa zoopsa zimagwirizana kwambiri ndi kukanika kwa hemostasis.Mosasamala kanthu za zotupa zolimba zolimba kapena khansa ya m'magazi, odwala adzakhala ndi vuto lalikulu la hypercoagulable kapena thrombosis.Adenocarcinoma yovuta ndi thrombosis ndiyofala kwambiri;

2. Ndikoyenera kutsindika kuti thrombosis ikhoza kukhala chizindikiro choyambirira cha chotupa.Odwala omwe ali ndi thrombosis yozama kwambiri ya mitsempha yomwe imalephera kuzindikira zoopsa zomwe zimayambitsa kutuluka kwa magazi, pamakhala chotupa chotheka.

♦Kufunika kwachipatala kwa matenda ena

1. Kuyang'anira chithandizo chamankhwala cha thrombolytic

Pa nthawi ya chithandizo, ngati kuchuluka kwa mankhwala a thrombolytic sikukwanira ndipo thrombus sichimasungunuka kwathunthu, D-dimer ndi FDP adzakhalabe apamwamba atafika pachimake;pamene kwambiri thrombolytic mankhwala azitaya magazi.

2. Kufunika kwa mankhwala a molekyulu yaing'ono ya heparin pambuyo pa opaleshoni

Odwala ovulala / opaleshoni nthawi zambiri amathandizidwa ndi anticoagulant prophylaxis.

Nthawi zambiri, mlingo wofunikira wa molekyulu yaing'ono ya heparin ndi 2850IU/d, koma ngati mulingo wa D-dimer wa wodwalayo ndi 2ug/ml pa tsiku la 4 pambuyo pa opaleshoni, mlingowo ukhoza kuwonjezeka mpaka 2 pa tsiku.

3. Acute aortic dissection (AAD)

AAD ndizomwe zimayambitsa kufa mwadzidzidzi kwa odwala.Kuzindikira msanga ndi kulandira chithandizo kungathandize kuchepetsa imfa ya odwala komanso kuchepetsa zoopsa zachipatala.

Zomwe zingatheke pakuwonjezeka kwa D-dimer mu AAD: Pambuyo pa gawo lapakati la khoma la chotengera cha aortic litawonongeka chifukwa cha zifukwa zosiyanasiyana, khoma la mitsempha limaphulika, zomwe zimapangitsa kuti magazi alowe mkati ndi kunja kwamkati kuti apange "boma labodza" , chifukwa cha magazi owona ndi onyenga m'kati mwake Pali kusiyana kwakukulu mu liwiro lothamanga, ndipo kuthamanga kwa magazi muzitsulo zabodza kumakhala kochepa, zomwe zingayambitse thrombosis mosavuta, kuchititsa kuti fibrinolytic system iyambe, ndipo pamapeto pake imalimbikitsa. kuchuluka kwa D-dimer.

03. Zomwe zimakhudza D-dimer ndi FDP

1. Makhalidwe a thupi

Okwezeka: Pali kusiyana kwakukulu kwa zaka, amayi apakati, masewera olimbitsa thupi, kusamba.

2.Kukhudza matenda

Kuwonjezeka: cerebrovascular stroke, thrombolytic therapy, matenda oopsa, sepsis, chotupa cha minofu, preeclampsia, hypothyroidism, matenda aakulu a chiwindi, sarcoidosis.

3.Hyperlipidemia ndi zotsatira za kumwa

Okwezeka: omwa;

Kuchepetsa: hyperlipidemia.

4. Zotsatira za mankhwala

okwera: heparin, antihypertensive mankhwala, urokinase, streptokinase ndi staphylokinase;

Kuchepa: kulera pakamwa ndi estrogen.
04. Mwachidule

Kuzindikira kwa D-dimer ndi FDP ndizotetezeka, zosavuta, zachangu, zotsika mtengo, komanso zokhudzidwa kwambiri.Onsewa adzakhala ndi kusintha kosiyanasiyana kwa matenda a mtima, matenda a chiwindi, matenda a cerebrovascular, matenda oopsa a mimba, ndi pre-eclampsia.Ndikofunika kuweruza kuopsa kwa matendawa, kuyang'anira chitukuko ndi kusintha kwa matendawa, ndikuwunika momwe matendawa akuyendera.zotsatira.