01. Mmata mbụ na D-dimer, FDP

1. FDP bụ okwu n'ozuzu maka ụdị mmebi dị iche iche nke fibrin na fibrinogen n'okpuru ọrụ nke plasmin, nke na-egosipụtakarị ọkwa fibrinolytic n'ozuzu nke ahụ;

2. D-dimer bụ ngwaahịa na-emebi emebi nke fibrin na-ejikọta ya n'okpuru ọrụ nke plasmin, na mmụba nke ọkwa ya na-egosi ịdị adị nke hyperfibrinolysis nke abụọ;

02. Ngwa ụlọ ọgwụ nke D-dimer na FDP

Ewezuga thrombosis venous (VTE gụnyere DVT, PE)

Izi ezi nke D-dimer mwepu na-adịghị mma nke thrombosis miri emi (DVT) nwere ike iru 98%-100%

Enwere ike iji nchọpụta D-dimer wepụ thrombosis venous

♦ Ihe dị mkpa na nchọpụta nke DIC

1. DIC bụ usoro pathophysiological dị mgbagwoju anya na ọrịa thrombo-hemorrhagic nke ụlọ ọgwụ nwetara siri ike.Ọtụtụ ndị DIC nwere mmalite ngwa ngwa, ọrịa mgbagwoju anya, mmepe ngwa ngwa, nchọpụta siri ike, na prognosis dị ize ndụ.Ọ bụrụ na a chọpụtaghị ya n'oge ma mesoo ya nke ọma, na-etinyekarị ndụ onye ọrịa n'ihe egwu;

2. D-dimer nwere ike igosipụta ịdị njọ nke DIC ruo n'ókè ụfọdụ, FDP nwere ike iji nyochaa mmepe nke ọrịa ahụ mgbe achọpụtara nchoputa ahụ, na antithrombin (AT) na-enyere aka ịghọta oke ọrịa ahụ na irè nke ọrịa ahụ. ọgwụgwọ heparin Nchikota nke D-dimer, FDP na AT ule aghọwo ihe kacha mma maka nchoputa DIC.

♦ Ihe dị mkpa na ụbụrụ ọjọọ

1. Ụbụrụ ọjọọ nwere njikọ chiri anya na arụghị ọrụ nke hemostasis.N'agbanyeghị etuto siri ike siri ike ma ọ bụ leukemia, ndị ọrịa ga-enwe ọnọdụ hypercoagulable siri ike ma ọ bụ thrombosis.Adenocarcinoma gbagwojuru anya site na thrombosis bụ nke a na-ahụkarị;

2. Okwesiri ikwadosi ike na thrombosis nwere ike bu ihe omuma nke mbu nke etuto.N'ime ndị ọrịa nwere thrombosis miri emi nke na-adịghị achọpụta ihe ize ndụ nke thrombosis ọbara ọgbụgba, enwere ike ịnwe etuto ahụ.

♦ Clinical mkpa nke ọrịa ndị ọzọ

1. Nyochaa ọgwụgwọ ọgwụ thrombolytic

N'ime usoro ọgwụgwọ, ọ bụrụ na ọnụọgụ ọgwụ thrombolytic ezughị ezu na thrombus adịghị agbaze kpamkpam, D-dimer na FDP ga-anọgide na-enwe ọkwa dị elu mgbe ha rutere elu;ebe oke ọgwụ thrombolytic ga-abawanye ohere nke ọbara ọgbụgba.

2. Mkpa nke obere molecule heparin ọgwụgwọ mgbe ịwachara ahụ

A na-agwọkarị ndị ọrịa nwere trauma/ịwa ahụ site na ọgwụ mgbochi mgbochi obi.

N'ozuzu, isi dose nke obere heparin molekul bụ 2850IU/d, ma ọ bụrụ na ọkwa D-dimer nke onye ọrịa bụ 2ug/ml n'ụbọchị nke anọ ka a wachara ya ahụ, enwere ike ịbawanye dose ahụ ruo ugboro abụọ n'ụbọchị.

3. Mgbasa akwara aortic (AAD)

AAD bụ ihe na-akpatakarị ọnwụ mberede na ndị ọrịa.Nchọpụta mbụ na ọgwụgwọ nwere ike ibelata ọnụọgụ ọnwụ nke ndị ọrịa ma belata ihe egwu ahụike.

Usoro nwere ike ime maka mmụba nke D-dimer na AAD: Mgbe etiti oyi akwa nke mgbidi arịa aortic mebiri emebi n'ihi ihe dị iche iche, mgbidi vaskụla ahụ na-agbaji, na-eme ka ọbara na-abanye n'ime ime na n'èzí na-emepụta "oghere ụgha" , N'ihi eziokwu na ọbara ụgha dị n'ime oghere E nwere nnukwu ọdịiche dị na ọsọ ọsọ ọsọ, na ọsọ ọsọ na-agba ọsọ na oghere ụgha dị ntakịrị, nke nwere ike ime ka thrombosis dị mfe, mee ka usoro fibrinolytic rụọ ọrụ, na n'ikpeazụ kwalite. mmụba nke ọkwa D-dimer.

03. Ihe ndị na-emetụta D-dimer na FDP

1. Njirimara anụ ahụ

Elu elu: E nwere nnukwu ọdịiche dị na afọ, ụmụ nwanyị dị ime, mgbatị ahụ siri ike, ịhụ nsọ.

2.Mmetụta ọrịa

Elu: ọrịa strok cerebrovascular, ọgwụgwọ thrombolytic, ọrịa siri ike, sepsis, gangrene anụ ahụ, preeclampsia, hypothyroidism, ọrịa imeju siri ike, sarcoidosis.

3.Hyperlipidemia na mmetụta nke ịṅụ mmanya

Elu: ndị na-aṅụ mmanya;

Belata: hyperlipidemia.

4. Mmetụta ọgwụ ọjọọ

Ebuli elu: heparin, ọgwụ antihypertensive, urokinase, streptokinase na staphylokinase;

Mbelata: ọgwụ mgbochi ọnụ na estrogen.
04. Nchịkọta

Nchọpụta D-dimer na FDP dị mma, dị mfe, ngwa ngwa, nke akụ na ụba na nke ukwuu.Ha abụọ ga-enwe mgbanwe dị iche iche nke ọrịa obi, ọrịa imeju, ọrịa cerebrovascular, ọbara mgbali elu nke ime ime, na pre-eclampsia.Ọ dị mkpa ikpebi ịdị njọ nke ọrịa ahụ, nyochaa mmepe na mgbanwe nke ọrịa ahụ, ma nyochaa prognosis nke mmetụta ọgwụgwọ.mmetụta.