01. Onye mbụ m hụrụ D-dimer, FDP

1. FDP bụ okwu izugbe maka ngwaahịa mmebi dị iche iche nke fibrin na fibrinogen n'okpuru ọrụ nke plasmin, nke na-egosipụtakarị ọkwa fibrinolytic zuru oke nke ahụ;

2. D-dimer bụ ngwaahịa mmebi kpọmkwem nke fibrin jikọtara ọnụ n'okpuru ọrụ nke plasmin, mmụba nke ọkwa ya na-egosikwa na enwere hyperfibrinolysis nke abụọ;

02. Ngwa D-dimer na FDP n'ụlọọgwụ

E wezụga thrombosis venous (VTE gụnyere DVT, PE)

Izi ezi nke mwepu D-dimer na-adịghị mma nke thrombosis miri emi (DVT) nwere ike iru 98%-100%

Enwere ike iji nchọpụta D-dimer wepụ thrombosis venous

♦Mmetụta dị mkpa na nchọpụta nke DIC

1. DIC bụ usoro ọrịa dị mgbagwoju anya na ọrịa thrombosis-hemorrhagic siri ike enwetara. Ọtụtụ DICs na-amalite ngwa ngwa, ọrịa dị mgbagwoju anya, mmepe ngwa ngwa, nchọpụta siri ike, na amụma dị ize ndụ. Ọ bụrụ na achọpụtaghị ya n'oge ma gwọọ ya nke ọma, ọtụtụ mgbe ọ na-etinye ndụ onye ọrịa n'ihe ize ndụ;

2. D-dimer nwere ike igosi oke DIC, enwere ike iji FDP nyochaa mmepe nke ọrịa ahụ mgbe achọpụtachara nchoputa ya, antithrombin (AT) na-enyekwa aka ịghọta oke ọrịa ahụ na irè nke ọgwụgwọ heparin. Nchikota nke nnwale D-dimer, FDP na AT aghọwo ihe ngosi kachasị mma maka ịchọpụta DIC.

♦Mmetụta dị na etuto ọjọọ

1. Ọrịa kansa nwere njikọ chiri anya na nsogbu nke hemostasis. N'agbanyeghị etuto siri ike ma ọ bụ leukemia, ndị ọrịa ga-enwe ọnọdụ siri ike nke na-anaghị agbakọ ọbara ma ọ bụ thrombosis. Adenocarcinoma nke thrombosis na-akpata bụ nke a na-ahụkarị;

2. Ọ dị mkpa ka a mata na thrombosis nwere ike ịbụ ihe mgbaàmà mbụ nke etuto ahụ. N'ime ndị ọrịa nwere thrombosis miri emi nke akwara na-anaghị achọpụta ihe nwere ike ibute thrombosis ọbara ọgbụgba, o nwere ike inwe etuto ahụ nwere ike ịpụta.

♦Mmetụta ahụike nke ọrịa ndị ọzọ

1. Nlekota nke ọgwụgwọ ọgwụ thrombolytic

N'oge ọgwụgwọ ahụ, ọ bụrụ na ọnụọgụ ọgwụ thrombolytic ezughi oke ma thrombus agbazeghị kpamkpam, D-dimer na FDP ga-anọgide na-enwe ọkwa dị elu mgbe ha ruru oke; ebe oke ọgwụ thrombolytic ga-eme ka ohere nke ọbara ọgbụgba dịkwuo elu.

2. Mkpa ọgwụgwọ heparin obere molekul mgbe a wachara ya ahụ

A na-ejikarị ọgwụ mgbochi anticoagulant agwọ ndị nwere mmerụ ahụ/ịwa ahụ.

N'ozuzu, usoro ọgwụgwọ heparin dị mfe bụ 2850IU/ụbọchị, mana ọ bụrụ na ọkwa D-dimer nke onye ọrịa bụ 2ug/ml n'ụbọchị nke anọ mgbe a wachara ya ahụ, enwere ike ịbawanye dose ahụ ruo ugboro abụọ n'ụbọchị.

3. Ngwuputa akwara obi (AAD)

AAD bụ ihe na-akpata ọnwụ mberede n'etiti ndị ọrịa. Nchọpụta na ọgwụgwọ n'oge nwere ike ibelata ọnụọgụ ọnwụ nke ndị ọrịa ma belata ihe egwu ahụike.

Usoro o kwere mee maka mmụba nke D-dimer na AAD: Mgbe akwa etiti nke mgbidi arịa akwara mebiri emebi n'ihi ọtụtụ ihe, mgbidi akwara na-agbawa, na-eme ka ọbara bata n'ime na mpụta iji mepụta "oghere ụgha", n'ihi ọbara eziokwu na nke ụgha dị n'ime oghere ahụ E nwere nnukwu ọdịiche na ọsọ mmiri, ọsọ mmiri dị n'ime oghere ụgha ahụ na-adị nwayọ nwayọ, nke nwere ike ibute thrombosis ngwa ngwa, mee ka sistemụ fibrinolytic rụọ ọrụ, ma mechaa kwalite mmụba nke ọkwa D-dimer.

03. Ihe ndị na-emetụta D-dimer na FDP

1. Àgwà anụ ahụ

Elu: E nwere nnukwu ọdịiche dị n'afọ, ụmụ nwanyị dị ime, mmega ahụ siri ike, na nsọ nwanyị.

2. Mmetụta ọrịa

Eriri: ọrịa strok cerebrovascular, ọgwụgwọ thrombolytic, ọrịa siri ike, sepsis, gangrene anụ ahụ, preeclampsia, hypothyroidism, ọrịa imeju siri ike, sarcoidosis.

3.Ọbara ọbara na mmetụta nke ịṅụ mmanya

Ebuli elu: ndị na-aṅụ mmanya;

Belata: hyperlipidemia.

4. Mmetụta ọgwụ

Ebuliri elu: heparin, ọgwụ mgbochi ọbara mgbali elu, urokinase, streptokinase na staphylokinase;

Mbelata: ọgwụ mgbochi afọ ime na estrogen.
04. Nchịkọta

Nchọpụta D-dimer na FDP dị nchebe, dị mfe, ngwa ngwa, dị ọnụ ala, ma dịkwa oke mkpa. Ha abụọ ga-enwe mgbanwe dị iche iche na ọrịa obi, ọrịa imeju, ọrịa cerebrovascular, ọbara mgbali elu nke afọ ime kpatara, na pre-eclampsia. Ọ dị mkpa ịtụle oke ọrịa ahụ, nyochaa mmepe na mgbanwe nke ọrịa ahụ, ma nyochaa amụma nke mmetụta ọgwụgwọ.