Thaum cev xeeb tub ib txwm, lub plawv tso zis ntau ntxiv thiab qhov tiv thaiv ntawm lub plawv txo qis thaum lub hnub nyoog cev xeeb tub nce ntxiv. Feem ntau ntseeg tias lub plawv tso zis pib nce ntxiv thaum 8 txog 10 lub lis piam ntawm cev xeeb tub, thiab ncav cuag qhov siab tshaj plaws thaum 32 txog 34 lub lis piam ntawm cev xeeb tub, uas yog 30% txog 45% siab dua li thaum tsis cev xeeb tub, thiab tswj qib no kom txog thaum yug menyuam. Qhov txo qis ntawm qhov tiv thaiv ntawm cov hlab ntsha sab nraud txo cov ntshav siab, thiab cov ntshav siab diastolic txo qis heev, thiab qhov sib txawv ntawm lub plawv dhia dav dua. Txij li 6 txog 10 lub lis piam ntawm cev xeeb tub, cov ntshav ntim ntawm cov poj niam cev xeeb tub nce ntxiv thaum lub hnub nyoog cev xeeb tub nce ntxiv, thiab nce li ntawm 40% thaum kawg ntawm cev xeeb tub, tab sis qhov nce ntawm cov ntshav plasma ntim ntau dua li tus lej ntawm cov qe ntshav liab, plasma nce ntxiv 40% txog 50%, thiab cov qe ntshav liab nce ntxiv 10% txog 15%. Yog li ntawd, thaum cev xeeb tub ib txwm, cov ntshav raug diluted, qhia tias yog cov ntshav viscosity txo qis, hematocrit txo qis, thiab cov ntshav erythrocyte sedimentation nce ntxiv [1].

Cov yam ntxwv ntshav coagulation Ⅱ, Ⅴ, VII, Ⅷ, IX, thiab Ⅹ txhua yam nce ntxiv thaum cev xeeb tub, thiab tuaj yeem ncav cuag 1.5 txog 2.0 npaug ntawm qhov ib txwm muaj thaum cev xeeb tub nruab nrab thiab lig, thiab cov haujlwm ntawm cov yam ntxwv coagulation Ⅺ thiab  txo qis. Fibrinopeptide A, fibrinopeptide B, thrombinogen, platelet factor Ⅳ thiab fibrinogen nce ntxiv ntau, thaum antithrombin Ⅲ thiab protein C thiab protein S txo qis. Thaum cev xeeb tub, lub sijhawm prothrombin thiab lub sijhawm ua haujlwm ib nrab prothrombin raug luv dua, thiab cov ntsiab lus plasma fibrinogen nce ntxiv ntau, uas tuaj yeem nce mus txog 4-6 g / L hauv peb lub hlis thib peb, uas yog kwv yees li 50% siab dua li thaum tsis cev xeeb tub. Tsis tas li ntawd, plasminogen nce ntxiv, lub sijhawm euglobulin yaj tau ntev dua, thiab kev hloov pauv coagulation-anticoagulation ua rau lub cev nyob rau hauv lub xeev hypercoagulable, uas tau txais txiaj ntsig zoo rau kev hemostasis tom qab placental abruption thaum lub sijhawm yug menyuam. Ntxiv rau, lwm yam hypercoagulable thaum cev xeeb tub suav nrog kev nce ntawm tag nrho cov cholesterol, phospholipids thiab triacylglycerols hauv cov ntshav, androgen thiab progesterone secreted los ntawm placenta txo cov nyhuv ntawm qee cov ntshav coagulation inhibitors, placenta, uterine decidua thiab embryos. Qhov muaj cov tshuaj thromboplastin, thiab lwm yam, tuaj yeem txhawb cov ntshav kom nyob rau hauv lub xeev hypercoagulable, thiab qhov kev hloov pauv no yog exacerbated nrog kev nce ntawm lub hnub nyoog gestational. Medium hypercoagulation yog ib qho kev ntsuas tiv thaiv physiological, uas yog pab txhawb kom fibrin deposition hauv cov hlab ntsha, phab ntsa uterine thiab placental villi, pab tswj kev ncaj ncees ntawm placenta thiab tsim thrombus vim stripping, thiab pab txhawb kom sai hemostasis thaum thiab tom qab yug menyuam. , yog ib qho tseem ceeb mechanism los tiv thaiv postpartum hemorrhage. Tib lub sijhawm ntawm coagulation, theem nrab fibrinolytic kev ua ub no kuj pib tshem tawm thrombus hauv uterine spiral arteries thiab venous sinuses thiab ua kom nrawm dua qhov rov ua dua thiab kho ntawm endometrium [2].

Txawm li cas los xij, lub xeev hypercoagulable kuj tseem tuaj yeem ua rau muaj ntau yam teeb meem kev yug menyuam. Nyob rau xyoo tas los no, kev tshawb fawb tau pom tias ntau tus poj niam cev xeeb tub muaj feem yuav muaj thrombosis. Cov kab mob no ntawm thromboembolism hauv cov poj niam cev xeeb tub vim muaj teeb meem caj ces lossis cov yam ntxwv txaus ntshai xws li cov protein anticoagulant, coagulation factors, thiab fibrinolytic proteins hu ua thrombosis. (thrombophilia), tseem hu ua lub xeev prothrombotic. Lub xeev prothrombotic no tsis tas yuav ua rau muaj kab mob thrombotic, tab sis yuav ua rau muaj kev tsis zoo ntawm cev xeeb tub vim muaj kev tsis sib npaug ntawm cov txheej txheem coagulation-anticoagulation lossis fibrinolytic kev ua haujlwm, microthrombosis ntawm uterine spiral arteries lossis villus, ua rau placental perfusion tsis zoo lossis txawm tias infarction, xws li Preeclampsia, placental abruption, placental infarction, disseminated intravascular coagulation (DIC), fetal kev loj hlob txwv, rov ua dua miscarriage, stillbirth thiab premature birth, thiab lwm yam, tuaj yeem ua rau niam thiab perinatal tuag hauv cov xwm txheej hnyav.