A cikin ciki na yau da kullun, fitowar zuciya yana ƙaruwa kuma juriyar gefe yana raguwa yayin da shekarun haihuwa ke ƙaruwa. Gabaɗaya ana kyautata zaton cewa fitowar zuciya yana fara ƙaruwa a makonni 8 zuwa 10 na ciki, kuma yana kaiwa kololuwa a makonni 32 zuwa 34 na ciki, wanda ya fi kashi 30 zuwa 45% fiye da na lokacin da ba a yi ciki ba, kuma yana riƙe da wannan matakin har sai haihuwa. Rage juriyar jijiyoyin jiki na gefe yana rage matsin lamba na jijiyoyi, kuma hawan jini na diastolic yana raguwa sosai, kuma bambancin matsin lamba na bugun jini yana faɗaɗa. Daga makonni 6 zuwa 10 na ciki, yawan jinin mata masu juna biyu yana ƙaruwa tare da ƙaruwar shekarun haihuwa, kuma yana ƙaruwa da kusan kashi 40% a ƙarshen ciki, amma ƙaruwar yawan jinin jini ya fi yawan ƙwayoyin jinin ja, plasma yana ƙaruwa da kashi 40% zuwa 50%, kuma ƙwayoyin jinin ja suna ƙaruwa da kashi 10% zuwa 15%. Saboda haka, a cikin ciki na yau da kullun, jinin yana narkewa, yana bayyana a matsayin raguwar danko na jini, raguwar hematocrit, da kuma ƙaruwar ƙimar sedimentation na erythrocyte [1].

Abubuwan da ke haifar da coagulation na jini Ⅱ, Ⅴ, VII, Ⅷ, IX, da Ⅹ duk suna ƙaruwa yayin daukar ciki, kuma suna iya kaiwa sau 1.5 zuwa 2.0 fiye da yadda aka saba a tsakiyar ciki da kuma ƙarshen ciki, kuma ayyukan abubuwan coagulation Ⅺ da ❰ suna raguwa. Fibrinopeptide A, fibrinopeptide B, thrombogen, platelet factor Ⅳ da fibrinogen sun ƙaru sosai, yayin da antithrombin Ⅲ da furotin C da furotin S suka ragu. A lokacin daukar ciki, lokacin prothrombin da lokacin prothrombin da aka kunna yana raguwa, kuma yawan sinadarin fibrinogen na plasma yana ƙaruwa sosai, wanda zai iya ƙaruwa zuwa 4-6 g/L a cikin watanni uku na uku, wanda ya fi kusan 50% girma fiye da na lokacin da ba a yi ciki ba. Bugu da ƙari, plasminogen ya ƙaru, lokacin narkewar euglobulin ya tsawaita, kuma canje-canjen coagulation-anticoagulation sun sa jiki ya kasance cikin yanayin coagulation mai yawa, wanda ya kasance mai amfani ga ingantaccen hemostasis bayan bugun mahaifa yayin haihuwa. Bugu da ƙari, wasu abubuwan da ke iya haifar da yawan zubar jini a lokacin daukar ciki sun haɗa da ƙaruwar jimlar cholesterol, phospholipids da triacylglycerols a cikin jini, androgen da progesterone da mahaifa ke fitarwa suna rage tasirin wasu masu hana zubar jini a jini, placenta, decidua na mahaifa da embryos. Kasancewar abubuwan thromboplastin, da sauransu, na iya haɓaka jinin ya kasance cikin yanayin zubar jini a jini, kuma wannan canjin yana ƙaruwa tare da ƙaruwar shekarun daukar ciki. Matsakaicin zubar jini wani ma'auni ne na kariya na jiki, wanda ke da amfani don kiyaye ajiyar fibrin a cikin jijiyoyin jini, bangon mahaifa da placenta villi, yana taimakawa wajen kiyaye daidaiton mahaifa da kuma samar da thrombus saboda cirewa, da kuma sauƙaƙe saurin zubar jini a lokacin haihuwa da kuma bayan haihuwa, muhimmin tsari ne don hana zubar jini bayan haihuwa. A lokaci guda na zubar jini, aikin fibrinolytic na biyu kuma yana fara cire thrombus a cikin jijiyoyin mahaifa da sinuses na venous kuma yana hanzarta farfadowa da gyara endometrium [2].

Duk da haka, yanayin da ke iya haifar da yawan zubar jini na iya haifar da matsaloli da yawa na haihuwa. A cikin 'yan shekarun nan, bincike ya gano cewa mata masu juna biyu da yawa suna iya kamuwa da thrombosis. Wannan yanayin cutar thromboembolism a cikin mata masu juna biyu saboda lahani na kwayoyin halitta ko abubuwan da ke haifar da haɗari kamar furotin na hana ɗaukar jini, abubuwan da ke haifar da zubar jini, da furotin fibrinolytic ana kiransa thrombosis. (thrombophilia), wanda kuma aka sani da yanayin prothrombotic. Wannan yanayin prothrombotic ba lallai bane ya haifar da cututtukan thrombosis ba, amma yana iya haifar da mummunan sakamako na ciki saboda rashin daidaito a cikin hanyoyin coagulation-anticoagulation ko aikin fibrinolytic, microthrombosis na jijiyoyin mahaifa ko villus, wanda ke haifar da mummunan perfusion na mahaifa ko ma infarction, kamar Preeclampsia, placental abruption, placental infarction, disseminated intravascular coagulation (DIC), ƙuntatawa na girma na tayi, sake zubar da ciki, haihuwa da haihuwa da wuri, da sauransu, na iya haifar da mutuwar uwa da haihuwa a cikin mawuyacin hali.