I roto i te ngākau ora, i te oko toto rānei, ka whiri, ka whiri rānei ētahi wāhanga o te toto hei hanga i tētahi puranga totoka, e kiia nei ko te thrombosis. Ko te puranga totoka e puta mai ana ka kiia ko te thrombus.
I raro i ngā āhuatanga noa, kei roto i te toto te pūnaha toto totoka me te pūnaha ārai totoka (te pūnaha fibrinolysis, te pūnaha fibrinolysis rānei) ā, ka mau tonu te taurite hihiri i waenganui i ngā mea e rua, kia pai ai te rere o te toto i roto i te pūnaha manawa me te pūnaha toto i roto i te āhua wai.
Ka whakahohehia tonutia ngā matū toto totoka i roto i te toto, ā, ka puta he iti o te thrombin hei hanga i te iti o te fibrin, ka whakatakotoria ki te intima o te uaua toto, kātahi ka whakarewahia e te pūnaha fibrinolytic whakahohe. I taua wā anō, ka whakapūpūhia tonutia, ka horoia hoki ngā matū toto totoka whakahohe e te pūnaha macrophage mononuclear.
Heoi, i raro i ngā āhuatanga mate, ka pakaru te taurite hihiri i waenga i te toto totoka me te toto ārai totoka, ka kaha te mahi a te pūnaha toto totoka, ā, ka totoka te toto i roto i te pūnaha manawa hei hanga i te thrombus.
E toru ngā āhuatanga o te thrombosis:
1. Te whara o te ngākau me ngā oko toto
He maeneene, he pai te āhua o te hononga o roto o te ngākau me ngā oko toto, ā, ka taea e ngā pūtau endothelial e kore e pakaru te aukati i te piri o ngā pereti toto me te ārai i te toto toto. Ina pakaru te kiriuhi o roto, ka taea te whakahohe i te pūnaha toto toto i roto i ngā huarahi maha.
Ka tukuna te matū totoka kiko (te matū totoka III) e te intima tuatahi kua pakaru, ā, ka whakahohehia te pūnaha totoka o waho.
Tuarua, i muri i te pakaru o te intima, ka pirau, ka necrosis, ka marere ngā pūtau endothelial, ka kitea ngā muka collagen i raro i te endothelium, ka whakahohe i te coagulation factor XII o te pūnaha coagulation endogenous, ka tīmata te pūnaha coagulation endogenous. Hei tāpiri, ka taratara te intima kua pakaru, ka āwhina i te whakatakotoranga me te piri o ngā pereti toto. I muri i te pakaru o ngā pereti toto e piri ana, ka tukuna he maha o ngā platelet factors, ka whakahohehia te tukanga coagulation katoa, ka whakapūpū te toto, ka hanga he thrombus.
Ka taea e ngā āhuatanga ā-tinana, matū me te koiora te whakararu i te intima o te pūnaha cardiovascular, pērā i te endocarditis i roto i te erysipelas poaka, te vasculitis pūkahukahu i roto i te niumōnia kau, te arteritis parasitic hoiho, ngā werohanga maha ki te wāhanga kotahi o te uaua, te whara me te pokanga o te pakitara o ngā uaua toto i te wā pokanga.
2. Ngā panonitanga o te rere o te toto
Ko te nuinga e pā ana ki te puhoi o te rere o te toto, te hanganga awhiowhio me te mutu o te rere o te toto.
I raro i ngā āhuatanga noa, he tere te rere o te toto, ā, kei waenganui o te uaua toto ngā toto whero, ngā pereti toto me ētahi atu wāhanga, e kiia nei ko te rere axial; ina puhoi te rere o te toto, ka rere ngā toto whero me ngā pereti toto ki te taha o te pakitara o te uaua toto, e kiia nei ko te rere taha, ka piki ake te mōrearea o te toto toto.
Ka pōturi te rere o te toto, ā, ka tino koretake te toto o ngā pūtau endothelial, ka puta te pirau me te nekrosis o ngā pūtau endothelial, ka ngaro te mahi hanga me te tuku i ngā mea ārai toto, me te kitea o te collagen, e whakahohe ana i te pūnaha toto toto me te whakatairanga i te thrombosis.
Ka taea hoki e te puhoi o te rere o te toto te whakangawari i te whakapiri o te thrombus kua hangaia ki te pakitara o ngā uaua toto, ā, ka piki haere tonu.
Nō reira, he maha ngā wā ka puta te totohu i roto i ngā uaua he puhoi te rere o te toto, ā, he ngāwari ki ngā ia hurihuri (i ngā takirere uaua). He tere te rere o te toto aorta, ā, he onge te kitenga o te totohu. E ai ki ngā tatauranga, e 4 ngā wā ka nui ake te putanga mai o te totohu uaua i tērā o te totohu uaua, ā, he maha ngā wā ka puta te totohu uaua i roto i te ngoikore o te ngakau, i muri i te pokanga, i roto rānei i ngā kararehe mate e takoto ana i roto i te kōhanga mō te wā roa.
Nō reira, he mea nui rawa te āwhina i ngā kararehe mate kua roa e takoto ana, ā, i muri i te pokanga, kia mahi i ētahi mahi tika hei ārai i te toto toto.
3. Ngā panonitanga o ngā āhuatanga o te toto.
Ko te nuinga e pā ana ki te pikinga o te toto totoka. Pērā i ngā wera nui, te maroke, me ētahi atu, te whakawhāiti toto, te whara nui, i muri i te whānautanga, me te ngaronga toto nui i muri i ngā pokanga nui, ka taea te whakanui ake i te maha o ngā pereti toto i roto i te toto, te whakanui ake i te matotoru o te toto, me te whakanui ake i te ihirangi o te fibrinogen, te thrombin me ētahi atu mea totoka i roto i te toto. Ka taea e ēnei mea te whakatairanga i te thrombosis.
Whakarāpopototanga
He maha ngā wā ka noho tahi ngā āhuatanga e toru o runga ake nei i roto i te tukanga o te thrombosis, ā, ka pā tetahi ki tetahi, engari he āhuatanga motuhake e whai wāhi nui ana ki ngā wāhanga rerekē o te thrombosis.
Nō reira, i roto i ngā mahi haumanu, ka taea te ārai i te totohu toto mā te mārama tika ki ngā āhuatanga o te totohu toto, me te tango i ngā mahi e rite ana ki te āhuatanga tūturu. Pērā i te pokanga me aro ki te mahi mārie, me ngana ki te karo i te kino o ngā oko toto. Mō te weronga roa o te uaua, kaua e whakamahi i te wāhi kotahi, me ētahi atu.
Kāri pakihi
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