Ngaphansi kwezimo zomzimba, lezi zinhlelo ezimbili zokuhlangana kwegazi kanye ne-anticoagulation emzimbeni zigcina ibhalansi eguqukayo ukuze kugcinwe igazi ligeleza emithanjeni yegazi.Uma ibhalansi ingalingani, uhlelo lwe-anticoagulation luhamba phambili futhi ukuthambekela ukopha kujwayele ukwenzeka, futhi uhlelo lokuxhuma luhamba phambili futhi i-thrombosis ijwayele ukwenzeka.Uhlelo lwe-fibrinolysis ludlala indima ebalulekile ku-thrombolysis.Namuhla sizokhuluma ngezinye izinkomba ezimbili zesistimu ye-fibrinolysis, i-D-dimer ne-FDP, ukuqonda ngokugcwele i-hemostasis eyenziwa yi-thrombin ku-thrombus eqalwe yi-fibrinolysis.Ukuziphendukela kwemvelo.Nikeza ulwazi oluyisisekelo lomtholampilo mayelana ne-thrombosis yeziguli nomsebenzi wokuhlangana.
I-D-dimer iwumkhiqizo othile wokucekela phansi okhiqizwa i-fibrin monomer exhunywe yi-activated factor XIII bese i-hydrolyzed nge-plasmin.I-D-dimer isuselwa ku-cross-linked fibrin clot echithwa yi-plasmin.I-D-dimer ephakeme ibonisa ukuba khona kwe-hyperfibrinolysis yesibili (njenge-DIC).I-FDP igama elijwayelekile lemikhiqizo ewohlokayo ekhiqizwa ngemva kokuhlukaniswa kwe-fibrin noma i-fibrinogen ngaphansi kwesenzo se-plasmin ekhiqizwa ngesikhathi se-hyperfibrinolysis.I-FDP ihlanganisa i-fibrinogen (Fg) kanye nemikhiqizo ye-fibrin monomer (FM) (FgDPs), kanye nemikhiqizo yokuwohloka kwe-fibrin exhunywe ngokuphambana (FbDPs), phakathi kwayo ama-FbDP ahlanganisa ama-D-dimers nezinye izingcezu, futhi amazinga azo anda High abonisa ukuthi umzimba Umsebenzi we-fibrinolytic uyasebenza kakhulu (i-fibrinolysis eyinhloko noma i-fibrinolysis yesibili)
【Isibonelo】
Owesilisa oneminyaka ephakathi wangeniswa esibhedlela futhi imiphumela yokuhlolwa kwegazi yaba kanje:
| Into | Umphumela | Ibanga lesithenjwa |
| PT | 13.2 | 10-14s |
| I-APTT | 28.7 | 22-32s |
| TT | 15.4 | 14-21s |
| I-FIB | 3.2 | 1.8-3.5g/l |
| DD | 40.82 | 0-0.55mg/I FEU |
| I-FDP | 3.8 | 0-5mg/l |
| I-AT-III | 112 | 75-125% |
Izinto ezine ze-coagulation zonke zazingezinhle, i-D-dimer yayinhle, kanti i-FDP yayinegethivu, futhi imiphumela yayiphikisana.Ekuqaleni okwakusolwa ukuthi iwumphumela we-hook, isampula laphinde lahlolwa ukuhlolwa kokuhlanjululwa kwe-multiple kanye ne-1:10, umphumela waba kanje:
| Into | Okwangempela | 1:10 ukuhlanjululwa | Ibanga lesithenjwa |
| DD | 38.45 | 11.12 | 0-0.55mg/I FEU |
| I-FDP | 3.4 | Ngaphansi komkhawulo ophansi | 0-5mg/l |
Kungabonakala ekuhlanjululweni ukuthi umphumela we-FDP kufanele ube ojwayelekile, futhi i-D-dimer ayilayini ngemva kokuhlanjululwa, futhi kusolwa ukuphazamiseka.Ungafaki i-hemolysis, i-lipemia, ne-jaundice esimweni sesampula.Ngenxa yemiphumela engalingani ye-dilution, izimo ezinjalo zingase zenzeke ngokuphazanyiswa okuvamile kwamasosha omzimba we-heterophilic noma izici ze-rheumatoid.Hlola umlando wezokwelapha wesiguli futhi uthole umlando we-rheumatoid arthritis.Ilabhorethri Umphumela wokuhlolwa kwe-RF factor wawuphezulu uma kuqhathaniswa.Ngemva kokuxhumana nomtholampilo, isiguli saphawulwa futhi sakhipha umbiko.Ekulandeleni kwakamuva, isiguli sasingenazo izimpawu ezihlobene ne-thrombus futhi sahlulelwa njengecala elingelona iqiniso le-D-dimer.
【Fingqa】
I-D-dimer iyinkomba ebalulekile yokukhishwa okungalungile kwe-thrombosis.Inokuzwela okuphezulu, kodwa ukucaciswa okuhambisanayo kuzoba buthaka.Kukhona futhi ingxenye ethile yemibono engamanga.Inhlanganisela ye-D-dimer ne-FDP inganciphisa ingxenye ye-D- Ngokuthola okungelona iqiniso kwe-dimer, lapho umphumela waselabhorethri ubonisa ukuthi i-D-dimer ≥ FDP, kungenziwa izahlulelo ezilandelayo kumphumela wokuhlolwa:
1. Uma amanani ephansi (
2. Uma umphumela uyinani eliphezulu (>Inani lokunqanyulwa), hlaziya izici ezinomthelela, kungase kube nezici zokuphazamiseka.Kunconywa ukwenza ukuhlolwa kwe-dilution eminingi.Uma umphumela uwumugqa, kungenzeka ukuthi uphozithivu yangempela weqiniso.Uma ingekho emgqeni, amaphothizithi angamanga.Ungasebenzisa futhi i-reagent yesibili ukuze uqinisekise futhi uxhumane nomtholampilo kusenesikhathi.
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