Phantsi kweemeko ze-physiological, iinkqubo ezimbini zokujiya kwegazi kunye nokujiya kwegazi emzimbeni zigcina ibhalansi eguquguqukayo ukugcina igazi lihamba kwimithambo yegazi. Ukuba ibhalansi ayilingani, inkqubo yokujiya kwegazi iphambili kwaye ukuthambekela kokopha kuyenzeka, kwaye inkqubo yokujiya kwegazi iphambili kwaye ukujiya kwegazi kuyenzeka. Inkqubo ye-fibrinolysis idlala indima ebalulekileyo kwi-thrombolysis. Namhlanje siza kuthetha ngezinye izalathisi ezimbini zenkqubo ye-fibrinolysis, i-D-dimer kunye ne-FDP, ukuze siqonde ngokupheleleyo i-hemostasis eveliswa yi-thrombin kwi-thrombus eqalwe yi-fibrinolysis. Uphuhliso. Nika ulwazi olusisiseko lweklinikhi malunga nomsebenzi we-thrombosis kunye nokujiya kwegazi kwezigulane.
I-D-dimer yimveliso ethile yokubola eveliswa yi-fibrin monomer edityaniswe yi-activated factor XIII ize emva koko i-hydrolyzed yi-plasmin. I-D-dimer isuka kwi-cross-linked fibrin clot enyibilikiswe yi-plasmin. I-D-dimer ephakanyisiweyo ibonisa ukubakho kwe-hyperfibrinolysis yesibini (efana ne-DIC). I-FDP ligama eliqhelekileyo leemveliso zokubola eziveliswa emva kokuba i-fibrin okanye i-fibrinogen yahlulwe phantsi kwesenzo se-plasmin eveliswa ngexesha le-hyperfibrinolysis. I-FDP ibandakanya i-fibrinogen (Fg) kunye neemveliso ze-fibrin monomer (FM) (FgDPs), kunye neemveliso zokubola ze-fibrin ezidityaniswe (FbDPs), apho ii-FbDP ziquka ii-D-dimers kunye nezinye iziqwenga, kwaye amanqanaba azo ayanda. Okuphezulu kubonisa ukuba umsebenzi we-fibrinolytic womzimba usebenza kakhulu (i-fibrinolysis ephambili okanye i-fibrinolysis yesibini)
【Umzekelo】
Indoda eneminyaka ephakathi ingeniswe esibhedlele kwaye iziphumo zovavanyo lokujiya kwegazi bezimi ngolu hlobo lulandelayo:
| Into | Isiphumo | Uluhlu lweReferensi |
| PT | 13.2 | 10-14s |
| I-APTT | 28.7 | 22-32s |
| TT | 15.4 | 14-21s |
| I-FIB | 3.2 | 1.8-3.5g/l |
| DD | 40.82 | 0-0.55mg/I FEU |
| I-FDP | 3.8 | 0-5mg/l |
| I-AT-III | 112 | 75-125% |
Izinto ezine zokujiya zonke bezinegative, i-D-dimer yayinepositive, kwaye i-FDP yayinegative, kwaye iziphumo beziphikisana. Ekuqaleni kwakucingelwa ukuba yi-hook effect, isampuli yaphinda yahlolwa ngovavanyo lokuqala lwe-multiple kunye ne-1:10 dilution, iziphumo bezingolu hlobo lulandelayo:
| Into | Yoqobo | 1:10 ukuxutywa | Uluhlu lweReferensi |
| DD | 38.45 | 11.12 | 0-0.55mg/I FEU |
| I-FDP | 3.4 | Ngaphantsi komda osezantsi | 0-5mg/l |
Kuyabonakala kwi-dilution ukuba isiphumo se-FDP kufuneka sibe sesiqhelekileyo, kwaye i-D-dimer ayilunganga emva kwe-dilution, kwaye kurhanelwa ukuba kukho ukuphazamiseka. Khupha i-hemolysis, i-lipemia, kunye ne-jaundice kwimeko yesampulu. Ngenxa yeziphumo ezingalinganiyo ze-dilution, iimeko ezinjalo zinokuvela kukuphazamiseka okuqhelekileyo kwi-heterophilic antibodies okanye izinto ze-rheumatoid. Jonga imbali yezonyango yesigulana kwaye ufumane imbali ye-rheumatoid arthritis. Ilebhu Iziphumo zovavanyo lwe-RF factor beziphezulu. Emva kokunxibelelana neklinikhi, isigulana saphawulwa saza sanikwa ingxelo. Kwingxelo elandelayo, isigulana sasingenazo iimpawu ezinxulumene ne-thrombus kwaye sagwetywa njengetyala le-D-dimer elingelona iqiniso.
【Shwankathela】
I-D-dimer luphawu olubalulekileyo lokungabikho kwe-thrombosis engalunganga. Inovakalelo oluphezulu, kodwa ukucaciswa okufanayo kuya kuba buthathaka. Kukwakho nenani elithile lee-positive ezingezizo. Ukudibana kwe-D-dimer kunye ne-FDP kunokunciphisa inxalenye ye-D- Kwi-positive engezizo ze-dimer, xa iziphumo zelebhu zibonisa ukuba i-D-dimer ≥ FDP, ezi zigwebo zilandelayo zinokwenziwa kwisiphumo sovavanyo:
1. Ukuba amaxabiso aphantsi (
2. Ukuba isiphumo sixabiso eliphezulu (>Ixabiso elinqumliweyo), hlalutya izinto ezichaphazelayo, kunokubakho izinto eziphazamisayo. Kucetyiswa ukuba kwenziwe uvavanyo oluninzi lokuxuba. Ukuba isiphumo sisemgceni, kunokwenzeka ukuba kubekho i-positive yokwenyani. Ukuba asiyo-linear, kukho izinto ezingalunganga. Ungasebenzisa ne-reagent yesibini ukuqinisekisa kwaye unxibelelane neklinikhi ngexesha.
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