I-Thrombosis idla ngokuba nezi meko zintathu zilandelayo:

1. Intliziyo kunye nomthambo wegazi ngexesha lokulimala okusondeleyo

I-intima yemithambo yegazi eqhelekileyo nentliziyo ayiguquki kwaye igudile, kwaye iiseli ze-endothelial ezingaphakathi zinokuthintela ukunamathela kweplatelet kunye nokuthintela ukujiya kwegazi. Xa i-membrane yangaphakathi yonakele, inkqubo yokujiya kwegazi inokwenziwa isebenze ngeendlela ezininzi.

I-intima yokuqala eyonakeleyo ikhupha i-tissue coagulation factor (i-coagulation factor III), evuselela inkqubo ye-extrinsic coagulation.
Okwesibini, emva kokuba i-intima yonakele, iiseli ze-endothelial ziyawohloka, zife, kwaye ziphume, ziveze imicu ye-collagen phantsi kwe-endothelium, ngaloo ndlela zivuselela i-coagulation factor XII yenkqubo ye-endogenous coagulation kwaye ziqalise inkqubo ye-endogenous coagulation. Ukongeza, i-intima eyonakeleyo iba rhabaxa, nto leyo ekhuthaza ukufakwa kweplatelet kunye nokunamathela. Emva kokuba iiplatelet ezinamatheleyo ziqhekekile, kukhutshwa izinto ezahlukeneyo zeplatelet, kwaye yonke inkqubo ye-coagulation iyasebenza, nto leyo ebangela ukuba igazi lijiye kwaye lenze i-thrombus.
Izinto ezahlukeneyo zomzimba, iikhemikhali kunye nebhayoloji zinokubangela umonakalo kwi-intima yentliziyo, njenge-endocarditis kwi-erysipelas yehagu, i-pulmonary vasculitis kwi-bovine pneumonia, i-equine parasitic arteritis, ukujova okuphindaphindiweyo kwindawo enye yomthambo, ukwenzakala kunye nokugqobhozwa kodonga lwemithambo yegazi ngexesha lotyando.

2. Utshintsho kwimeko yokuhamba kwegazi

Ngokuyintloko ibhekisa ekucotheni kokuhamba kwegazi, ukwakheka kwe-vortex kunye nokuyeka ukuhamba kwegazi.
Phantsi kweemeko eziqhelekileyo, izinga lokuhamba kwegazi likhawuleza, kwaye iiseli ezibomvu zegazi, iiplatelets kunye nezinye izinto zixinene embindini womthambo wegazi, obizwa ngokuba yi-axial flow; xa izinga lokuhamba kwegazi lihla, iiseli ezibomvu zegazi kunye neeplatelets ziya kuhamba kufutshane nodonga lomthambo wegazi, olubizwa ngokuba yi-side flow, oluyandisa i-thrombosis.
Ukuhamba kwegazi kuyehla, kwaye iiseli ze-endothelial azinawo umoya ococekileyo kakhulu, nto leyo ebangela ukuwohloka kunye nokuncipha kweeseli ze-endothelial, ukulahleka komsebenzi wazo wokwenza nokukhupha izinto ezilwa nokugabha igazi, kunye nokuvezwa kwe-collagen, evuselela inkqubo yokugabha igazi kwaye ikhuthaze i-thrombosis.
Ukuhamba kwegazi kancinci kunokwenza ukuba i-thrombus eyenziweyo ikwazi ukulungiseka lula eludongeni lwemithambo yegazi kwaye iqhubeke nokwanda.

Ngoko ke, i-thrombus idla ngokuvela kwimithambo yegazi ehamba kancinci kwaye ithambekele kwi-eddy currents (kwiivali zemithambo yegazi). Ukuhamba kwegazi kwi-aorta kuyakhawuleza, kwaye i-thrombus ayifumaneki rhoqo. Ngokwezibalo, ukwenzeka kwe-venous thrombosis kuphindwe kane kunokwe-arterial thrombosis, kwaye i-venous thrombosis idla ngokuvela kwintliziyo engasebenzi kakuhle, emva kotyando okanye kwizilwanyana ezigulayo ezilele esidlekeni ixesha elide.
Kungoko ke, kubaluleke kakhulu ukunceda izilwanyana ezigulayo ebezilele phantsi ixesha elide nasemva kotyando ukuba zenze imisebenzi efanelekileyo yokuthintela i-thrombosis.
3. Utshintsho kwiimpawu zegazi.

Ikakhulu ibhekisa ekunyukeni kokujiya kwegazi. Ezifana nokutsha kakhulu, ukuphelelwa ngamanzi emzimbeni, njl.njl. ukugxininisa igazi, ukwenzakala okukhulu, emva kokubeletha, kunye nokulahleka kwegazi okukhulu emva kotyando olukhulu kunokunyusa inani leeplatelets egazini, kwandise i-viscosity yegazi, kwaye kwandise umxholo we-fibrinogen, i-thrombin kunye nezinye izinto zokujiya kwegazi kwi-plasma. Ukwanda. Ezi zinto zinokukhuthaza i-thrombosis.