Pansi pa mikhalidwe ya thupi, machitidwe awiri a magazi oundana ndi oletsa magazi kuundana m'thupi amasunga bwino momwe magazi amayendera m'mitsempha yamagazi. Ngati mulingo uli wofanana, njira yoletsa magazi kuundana imakhala yochulukirapo ndipo magazi amayamba kutuluka, ndipo njira youndana imakhala yochulukirapo ndipo magazi amayamba kutuluka. Njira ya fibrinolysis imagwira ntchito yofunika kwambiri pakuchotsa magazi kuundana. Lero tikambirana za zizindikiro zina ziwiri za njira ya fibrinolysis, D-dimer ndi FDP, kuti timvetse bwino momwe magazi amatuluka chifukwa cha thrombin kupita ku thrombus yomwe imayambitsidwa ndi fibrinolysis. Kusintha kwa thupi. Perekani chidziwitso choyambira chachipatala chokhudza ntchito ya thrombosis ndi magazi kuundana kwa odwala.
D-dimer ndi chinthu chowonongeka chomwe chimapangidwa ndi fibrin monomer cholumikizidwa ndi activated factor XIII kenako n’kusungunuka ndi plasmin. D-dimer imachokera ku cross-linked fibrin clot yomwe imasungunuka ndi plasmin. D-dimer yokwezedwa imasonyeza kukhalapo kwa hyperfibrinolysis yachiwiri (monga DIC). FDP ndi mawu ofala a zinthu zowonongeka zomwe zimapangidwa pambuyo poti fibrin kapena fibrinogen yasweka chifukwa cha plasmin yomwe imapangidwa panthawi ya hyperfibrinolysis. FDP imaphatikizapo fibrinogen (Fg) ndi fibrin monomer (FM) products (FgDPs), komanso zinthu zowonongeka za fibrin (FbDPs), zomwe FbDPs zimaphatikizapo D-dimers ndi zidutswa zina, ndipo milingo yawo imawonjezeka. Zapamwamba zimasonyeza kuti ntchito ya fibrinolytic ya thupi ndi yoopsa kwambiri (primary fibrinolysis kapena secondary fibrinolysis)
【Chitsanzo】
Mwamuna wazaka zapakati adalowa mchipatala ndipo zotsatira za kuyezetsa magazi zinali motere:
| Chinthu | Zotsatira | Mndandanda wa Ma Reference |
| PT | 13.2 | 10-14s |
| APTT | 28.7 | masekondi 22-32 |
| TT | 15.4 | 14-21s |
| FIB | 3.2 | 1.8-3.5g/l |
| DD | 40.82 | 0-0.55mg/I FEU |
| FDP | 3.8 | 0-5mg/l |
| AT-III | 112 | 75-125% |
Zinthu zinayi zomwe zinapanga magazi oundana zinali zoipa, D-dimer inali yabwino, ndipo FDP inali yoipa, ndipo zotsatira zake zinali zotsutsana. Poyamba zinkaganiziridwa kuti ndi zotsatira za hook, chitsanzocho chinayang'aniridwanso ndi mayeso oyamba a multiple ndi 1:10 dilution, zotsatira zake zinali motere:
| Chinthu | Choyambirira | 1:10 kuchepetsedwa | Mndandanda wa Ma Reference |
| DD | 38.45 | 11.12 | 0-0.55mg/I FEU |
| FDP | 3.4 | Pansi pa malire otsika | 0-5mg/l |
Kutengera ndi kuchepetsedwa kwa magazi, zotsatira za FDP ziyenera kukhala zabwinobwino, ndipo D-dimer si yolunjika pambuyo pa kuchepetsedwa kwa magazi, ndipo kusokonezeka kumaganiziridwa. Chotsani hemolysis, lipemia, ndi jaundice pamlingo wa chitsanzocho. Chifukwa cha zotsatira zosayerekezeka za kuchepetsedwa kwa magazi, milandu yotereyi ingachitike chifukwa cha kusokonezeka kwa ma antibodies a heterophilic kapena zinthu za rheumatoid. Yang'anani mbiri yachipatala ya wodwalayo ndikupeza mbiri ya nyamakazi ya rheumatoid. Laboratory Zotsatira za kuyezetsa kwa RF factor zinali zapamwamba. Pambuyo polankhulana ndi chipatala, wodwalayo adanenedwa ndikuperekedwa lipoti. Pambuyo pake, wodwalayo analibe zizindikiro zokhudzana ndi thrombus ndipo adaweruzidwa kuti ndi mlandu wabodza wa D-dimer.
【Chidule】
D-dimer ndi chizindikiro chofunikira cha kuchotsedwa kwa thrombosis. Ili ndi mphamvu yowonjezereka, koma kutsimikizika kofananako kudzakhala kofooka. Palinso gawo lina la zabwino zabodza. Kuphatikiza kwa D-dimer ndi FDP kungachepetse gawo la D- Pa zabwino zabodza za dimer, pamene zotsatira za labotale zikusonyeza kuti D-dimer ≥ FDP, zigamulo zotsatirazi zitha kuperekedwa pa zotsatira za mayeso:
1. Ngati mitengo ili yotsika (
2. Ngati zotsatira zake ndi zapamwamba (>mtengo wodula), fufuzani zinthu zomwe zimakhudza, pakhoza kukhala zinthu zosokoneza. Ndikofunikira kuchita mayeso angapo ochepetsa mphamvu ya mankhwala. Ngati zotsatira zake ndi zolunjika, ndiye kuti pali mwayi wopeza zotsatira zenizeni. Ngati sizili zolunjika, ndiye kuti pali zabwino zabodza. Muthanso kugwiritsa ntchito reagent yachiwiri kuti mutsimikizire ndikulankhulana ndi chipatala nthawi yomweyo.
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