Thrombosis nthawi zambiri imakhala ndi zinthu zitatu izi:

1. Mtima ndi mitsempha yamagazi pa nthawi ya kuvulala

Intima ya mtima ndi mitsempha yamagazi yabwinobwino imakhala yosalala komanso yosalala, ndipo maselo a endothelial omwe ali mkati mwake amatha kuletsa kulumikizidwa kwa ma platelet ndi kuchepetsa magazi kuundana. Pamene nembanemba yamkati yawonongeka, dongosolo lozungulira magazi limatha kuyatsidwa m'njira zambiri.

Intima yoyamba yowonongeka imatulutsa chinthu cholimbitsa minofu (coagulation factor III), chomwe chimayambitsa dongosolo la extrinsic coagulation.
Kachiwiri, intima ikawonongeka, maselo a endothelial amawonongeka, kufalikira, ndikutuluka, zomwe zimapangitsa kuti ulusi wa collagen ukhale pansi pa endothelium, motero zimayambitsa coagulation factor XII ya endogenous coagulation system ndikuyamba endogenous coagulation system. Kuphatikiza apo, intima yowonongeka imakhala yolimba, zomwe zimapangitsa kuti ma platelet azisungidwa ndi kumamatira. Ma platelet omatiridwa akaphulika, zinthu zosiyanasiyana za platelet zimatulutsidwa, ndipo njira yonse yomatirira imayatsidwa, zomwe zimapangitsa kuti magazi azimatirira ndikupanga thrombus.
Zinthu zosiyanasiyana zakuthupi, zamakemikolo ndi zamoyo zimatha kuwononga mtima, monga endocarditis mu erysipelas ya nkhumba, pulmonary vasculitis mu bovine pneumonia, equine parasitic arteritis, jakisoni wobwerezabwereza m'dera lomwelo la mitsempha, Kuvulala ndi kubowoledwa kwa khoma la mitsempha yamagazi panthawi ya opaleshoni.

2. Kusintha kwa kayendedwe ka magazi

Makamaka amatanthauza kuyenda pang'onopang'ono kwa magazi, kupanga ma vortex ndi kusiya kuyenda kwa magazi.
Muzochitika zabwinobwino, kuthamanga kwa magazi kumakhala kofulumira, ndipo maselo ofiira a magazi, ma platelet ndi zigawo zina zimakhala pakati pa mtsempha wamagazi, womwe umatchedwa axial flow; pamene kuthamanga kwa magazi kukuchepa, maselo ofiira a magazi ndi ma platelet adzayenda pafupi ndi khoma la mtsempha wamagazi, wotchedwa side flow, womwe umawonjezera chiopsezo cha thrombosis.
Kuyenda kwa magazi kumachepa, ndipo maselo a endothelial amakhala ndi mpweya wochepa kwambiri, zomwe zimapangitsa kuti maselo a endothelial awonongeke komanso awonongeke, ntchito yawo yopangira ndi kutulutsa zinthu zotsutsana ndi magazi isamayende bwino, komanso collagen imalowa m'magazi, zomwe zimayambitsa magazi kuundana ndikulimbikitsa thrombosis.
Kuyenda pang'onopang'ono kwa magazi kungapangitsenso kuti thrombus yopangidwayo ikhale yosavuta kukonza pakhoma la mitsempha yamagazi ndikupitirira kukula.

Chifukwa chake, magazi otuluka m'mitsempha nthawi zambiri amapezeka m'mitsempha yomwe magazi amayenda pang'onopang'ono komanso yomwe imayenda pang'onopang'ono (pa ma valve a mitsempha). Magazi otuluka m'mitsempha yamagazi amathamanga, ndipo magazi otuluka m'mitsempha sapezeka kawirikawiri. Malinga ndi ziwerengero, kupezeka kwa magazi otuluka m'mitsempha kumawonjezeka nthawi 4 kuposa kwa magazi otuluka m'mitsempha yamagazi, ndipo magazi otuluka m'mitsempha nthawi zambiri amapezeka m'mtima, pambuyo pa opaleshoni kapena mwa nyama zodwala zomwe zagona m'chisa kwa nthawi yayitali.
Choncho, ndikofunikira kwambiri kuthandiza ziweto zodwala zomwe zakhala zikugona kwa nthawi yayitali komanso zitachitidwa opaleshoni kuti zichite zinthu zoyenera kuti zisawonongeke ndi thrombosis.
3. Kusintha kwa makhalidwe a magazi.

Makamaka amatanthauza kuwonjezeka kwa magazi oundana. Monga kupsa kwambiri, kutaya madzi m'thupi, ndi zina zotero, kukulitsa magazi, kuvulala kwambiri, pambuyo pobereka, ndi kutaya magazi kwambiri pambuyo pa opaleshoni yayikulu, kungapangitse kuchuluka kwa ma platelet m'magazi, kuwonjezera kukhuthala kwa magazi, ndikuwonjezera kuchuluka kwa fibrinogen, thrombin ndi zinthu zina zoundana m'magazi. Zinthuzi zimatha kuyambitsa thrombosis.