Thrombosis na-enwekarị ọnọdụ atọ ndị a:

1. Mmerụ ahụ dị n'obi na akwara ọbara

Mmetụta dị n'obi na arịa ọbara nkịtị dị mma ma dịkwa ire ụtọ, mkpụrụ ndụ endothelial ndị na-adịghị emebi emebi nwekwara ike igbochi njikọta platelet na mgbochi coagulation. Mgbe akpụkpọ ahụ dị n'ime mebiri emebi, a pụrụ ịgbalite usoro coagulation n'ọtụtụ ụzọ.

Mkpọchi mbụ mebiri emebi na-ewepụta ihe na-akpata coagulation nke anụ ahụ (coagulation factor III), nke na-eme ka sistemụ coagulation nke mpụga rụọ ọrụ.
Nke abụọ, mgbe intima mebiri emebi, mkpụrụ ndụ endothelial na-emebi emebi, necrosis, na wụfuo, na-ekpughe eriri collagen n'okpuru endothelium, si otú a na-eme ka coagulation factor XII nke sistemu coagulation endogenous rụọ ọrụ ma na-amalite sistemu coagulation endogenous. Na mgbakwunye, intima mebiri emebi na-aghọ ihe siri ike, nke na-eme ka platelet dị na njikọ na njikọta. Mgbe platelets ndị a gbawara, a na-ewepụta ọtụtụ ihe platelet, a na-emekwa ka usoro coagulation dum rụọ ọrụ, na-eme ka ọbara gbakọta ma mepụta thrombus.
Ihe dị iche iche nke anụ ahụ, kemịkalụ na ihe ndị dị ndụ nwere ike imebi obi, dịka endocarditis na erysipelas swine, vasculitis pulmonary na pneumonia ehi, equine parasitic arteritis, ịgba ọgwụ ugboro ugboro n'otu akụkụ nke akwara ahụ, mmerụ ahụ na mpụta nke mgbidi arịa ọbara n'oge ịwa ahụ.

2. Mgbanwe n'ọnọdụ ọbara na-erugharị

Isi ihe na-ezo aka bụ ọsọ ọbara na-aga nwayọ nwayọ, nhazi vortex na nkwụsị ọbara.
N'ọnọdụ nkịtị, ọsọ ọbara na-agba ọsọ, mkpụrụ ndụ ọbara uhie, platelet na ihe ndị ọzọ na-agbakọta n'etiti arịa ọbara, nke a na-akpọ axial flow; mgbe ọsọ ọbara na-ebelata, mkpụrụ ndụ ọbara uhie na platelet ga-asọfe nso na mgbidi arịa ọbara, nke a na-akpọ side flow, nke na-eme ka thrombosis dịkwuo elu.
Ọbara na-ebelata, mkpụrụ ndụ endothelial na-enwekwa oke hypoxic, na-akpata mmebi na necrosis nke mkpụrụ ndụ endothelial, na-efunahụ ọrụ ha nke imepụta na iwepụ ihe ndị na-egbochi ọbara, na ikpughe nke collagen, nke na-eme ka usoro coagulation rụọ ọrụ ma na-akwalite thrombosis.
Ọbara na-agba ọsọ nwayọ nwekwara ike ime ka thrombus e guzobere dị mfe idozi n'elu mgbidi arịa ọbara ma nọgide na-amụba.

Ya mere, thrombus na-apụtakarị n'akwara ndị nwere ọbara na-eru nwayọ nwayọ ma na-enwe ike ịnweta mmiri na-asọ asọ (n'ime valvụ venous). Ọbara na-eru ngwa ngwa, a naghịkwa ahụ thrombus. Dịka ọnụọgụgụ si kwuo, ihe na-eme na venous thrombosis karịrị nke venous thrombosis ugboro anọ, venous thrombosis na-apụtakarị na obi dara ada, mgbe a wachara ya ahụ ma ọ bụ n'ime anụmanụ ndị na-arịa ọrịa dina n'akwụ ruo ogologo oge.
Ya mere, ọ dị oke mkpa inyere anụmanụ ndị na-arịa ọrịa aka bụ́ ndị dinaala ogologo oge na mgbe a wachara ha ahụ ime ihe ụfọdụ kwesịrị ekwesị iji gbochie thrombosis.
3. Mgbanwe n'ihe gbasara ọbara.

Isi ihe na-ezo aka bụ mmụba nke coagulation ọbara. Dịka nnukwu ọkụ, nkụchi ahụ, wdg. itinye ọbara n'ime ihe, nnukwu mmerụ ahụ, mgbe a mụsịrị nwa, na nnukwu mfu ọbara mgbe a wasịrị ya ahụ nke ukwuu nwere ike ime ka ọnụọgụ platelet dị n'ọbara dịkwuo elu, mee ka ọbara dị nro, ma mee ka ọdịnaya nke fibrinogen, thrombin na ihe ndị ọzọ na-akpata coagulation dị na plasma dịkwuo elu. Ihe ndị a nwere ike ibute thrombosis.