A ƙarƙashin yanayin ilimin halittar jiki, tsarin guda biyu na zubar jini da hana zubar jini a jiki suna kiyaye daidaiton aiki don kiyaye jini yana gudana a cikin jijiyoyin jini. Idan daidaiton bai daidaita ba, tsarin hana zubar jini yana da rinjaye kuma yanayin zubar jini yana da saurin faruwa, kuma tsarin hada jini yana da rinjaye kuma thrombosis yana da saurin faruwa. Tsarin fibrinolysis yana taka muhimmiyar rawa a cikin zubar jini. A yau za mu yi magana game da sauran alamomi guda biyu na tsarin fibrinolysis, D-dimer da FDP, don fahimtar cikakken hemostasis da thrombin ke haifarwa zuwa thrombus wanda fibrinolysis ya fara. Juyin Halitta. Bayar da bayanai na asali na asibiti game da aikin zubar jini da aikin hada jini na marasa lafiya.
D-dimer wani takamaiman samfurin lalacewa ne da fibrin monomer ya samar ta hanyar connected factor XIII sannan ya samar da hydrolyzed ta plasmin. D-dimer an samo shi ne daga cross-linked fibrin clot wanda plasmin ya narke. D-dimer mai ɗagawa yana nuna kasancewar hyperfibrinolysis na biyu (kamar DIC). FDP kalma ce ta gabaɗaya don samfuran lalacewa da aka samar bayan an rushe fibrin ko fibrinogen ƙarƙashin aikin plasmin da aka samar yayin hyperfibrinolysis. FDP ya haɗa da fibrinogen (Fg) da fibrin monomer (FM) kayayyakin (FgDPs), da kuma samfuran lalata fibrin masu haɗin gwiwa (FbDPs), daga cikinsu FbDPs sun haɗa da D-dimers da sauran gutsuttsura, kuma matakan su suna ƙaruwa Babban yana nuna cewa aikin fibrinolytic na jiki yana da ƙarfi sosai (primary fibrinolysis ko secondary fibrinolysis)
【Misali】
An kwantar da wani namiji mai matsakaicin shekaru a asibiti kuma sakamakon gwajin jini ya kasance kamar haka:
| Abu | Sakamako | Nisa tsakanin Sharuɗɗa |
| PT | 13.2 | Shekaru 10-14 |
| APTT | 28.7 | 22-32s |
| TT | 15.4 | 14-21s |
| FIB | 3.2 | 1.8-3.5g/l |
| DD | 40.82 | 0-0.55mg/I FEU |
| FDP | 3.8 | 0-5mg/l |
| AT-III | 112 | 75-125% |
Abubuwa huɗu na coagulation duk ba su da kyau, D-dimer yana da kyau, FDP kuma ba shi da kyau, kuma sakamakon ya ci karo da juna. Da farko ana zargin cewa tasirin ƙugiya ne, an sake duba samfurin ta hanyar gwajin dilution na asali da kuma gwajin dilution na 1:10, sakamakon ya kasance kamar haka:
| Abu | Asali | 1:10 narkar da ruwa | Nisa tsakanin Sharuɗɗa |
| DD | 38.45 | 11.12 | 0-0.55mg/I FEU |
| FDP | 3.4 | Ƙasa da ƙananan iyaka | 0-5mg/l |
Za a iya gani daga narkarwar cewa sakamakon FDP ya kamata ya zama na al'ada, kuma D-dimer ba ya layi bayan narkarwa, kuma ana zargin tsangwama. A cire hemolysis, lipemia, da jaundice daga matsayin samfurin. Saboda rashin daidaiton sakamakon narkarwa, irin waɗannan shari'o'in na iya faruwa a cikin tsangwama gama gari tare da ƙwayoyin rigakafi na heterophilic ko abubuwan rheumatoid. Duba tarihin lafiyar majiyyaci kuma ku sami tarihin rheumatoid arthritis. Dakin gwaje-gwaje Sakamakon gwajin RF factor ya yi yawa. Bayan yin magana da asibitin, an lura da majiyyaci kuma an bayar da rahoto. A cikin binciken da aka yi daga baya, majiyyaci bai sami alamun da ke da alaƙa da thrombus ba kuma an yanke masa hukunci a matsayin shaidar ƙarya ta D-dimer.
【Takaita】
D-dimer muhimmin alama ce ta cire sinadarin thrombosis daga jini. Yana da babban ji na ƙwarai, amma takamaiman yanayin da ya dace zai yi rauni. Akwai kuma wani kaso na tabbataccen ƙarya. Haɗin D-dimer da FDP na iya rage wani ɓangare na D- Ga ƙaryan tabbataccen dimer, lokacin da sakamakon dakin gwaje-gwaje ya nuna cewa D-dimer ≥ FDP, ana iya yanke hukunci mai zuwa akan sakamakon gwajin:
1. Idan ƙimar ta yi ƙasa (
2. Idan sakamakon ya kasance mai girma (>ƙimar yankewa), yi nazarin abubuwan da ke tasiri, za a iya samun abubuwan da ke haifar da tsangwama. Ana ba da shawarar yin gwajin narkewa sau da yawa. Idan sakamakon ya kasance mai layi, to akwai yuwuwar samun sakamako mai kyau. Idan ba mai layi ba ne, to akwai yiwuwar samun sakamako mara kyau. Hakanan zaka iya amfani da reagent na biyu don tabbatarwa da kuma sadarwa da asibitin akan lokaci.
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