I-D-dimer itholakala ehlule lefibrin elixhunywe ngokuphambana elincibilikiswe yi-plasmin.Ibonisa ngokuyinhloko umsebenzi we-lytic we-fibrin.Isetshenziswa kakhulu ekuxilongeni kwe-venous thromboembolism, i-vein thrombosis ejulile kanye ne-pulmonary embolism ekusebenzeni komtholampilo.Ukuhlolwa kwekhwalithi ye-D-dimer kunegethivu, uma ukuhlolwa kwenani kufanele kube ngaphansi kuka-200μg/L.

Ukwenyuka kwe-D-dimer noma imiphumela emihle yokuhlolwa kuvame ukubonakala ezifweni ezihlobene ne-hyperfibrinolysis yesibili, njenge-hypercoagulable state, i-intravascular coagulation esakazwayo, isifo sezinso, ukwenqatshwa kokufakelwa kwesitho, kanye nokwelashwa kwe-thrombolytic.Ngaphezu kwalokho, lapho i-thrombosis ecushiwe emithanjeni yegazi yomzimba, noma izifo ezihambisana nomsebenzi we-fibrinolytic, i-D-dimer nayo izokwanda kakhulu.Izifo ezivamile ezifana ne-myocardial infarction, i-pulmonary embolism, i-thrombosis ejulile ye-vein thrombosis, i-cerebral infarction njll;ezinye izifo, ukuhlinzwa, izifo zesimila, kanye ne-necrosis yezicubu nakho kuholela ekwandeni kwe-D-dimer;ngaphezu kwalokho, ezinye izifo ze-autoimmune zabantu, njenge-rheumatic endocarditis, i-rheumatoid arthritis, i-systemic Lupus erythematosus, njll., zingase futhi zibangele ukwanda kwe-D-dimer.

Ngaphezu kokuhlonza izifo, ukutholwa komthamo kwe-D-dimer kungaphinda kubonise ngokwesilinganiso umphumela we-thrombolytic wezidakamizwa ekusebenzeni komtholampilo.Izici zezifo, njll., zonke ziwusizo.

Endabeni ye-D-dimer ephakeme, umzimba usengozini enkulu ye-thrombosis.Ngalesi sikhathi, isifo esiyinhloko kufanele sitholakale ngokushesha ngangokunokwenzeka, futhi uhlelo lokuvimbela i-thrombosis kufanele luqalwe ngokuvumelana nesikolo se-DVT.Ezinye izidakamizwa zingakhethelwa ukwelashwa kwe-anticoagulation, njengomjovo ongaphansi kwesikhumba wesisindo esiphansi se-heparin calcium noma i-rivaroxaban, enomphumela othile wokuvimbela ekwakhekeni kwe-thrombosis.Labo abanezilonda ze-thrombotic badinga isimila se-thrombolytic ngokushesha ngangokunokwenzeka phakathi nesikhathi segolide, futhi ngezikhathi ezithile ubuyekeze i-D-dimer.