I-D-dimer itholakala ku-cross-linked fibrin clot encibilikiswe yi-plasmin. Ibonisa kakhulu umsebenzi we-lytic we-fibrin. Isetshenziswa kakhulu ekuxilongweni kwe-venous thromboembolism, i-deep vein thrombosis kanye ne-pulmonary embolism emtholampilo. Ukuhlolwa kwekhwalithi ye-D-dimer akunawo umphumela, uma ukuhlolwa kwenani kufanele kube ngaphansi kuka-200μg/L.

Imiphumela yokuhlolwa eyandayo ye-D-dimer noma emihle ivame ukubonakala ezifweni ezihlobene ne-hyperfibrinolysis yesibili, njengesimo se-hypercoagulable, ukujiya kwemithambo yegazi okusabalele, isifo sezinso, ukwenqatshwa kokufakelwa kwezitho, kanye nokwelashwa nge-thrombolytic. Ngaphezu kwalokho, uma kukhona i-thrombosis esebenzayo emithanjeni yegazi yomzimba, noma izifo ezihambisana nomsebenzi we-fibrinolytic, i-D-dimer nayo izokwanda kakhulu. Izifo ezivamile ezifana ne-myocardial infarction, i-pulmonary embolism, i-lower end deep vein thrombosis, i-cerebral infarction Njll.; ezinye izifo, ukuhlinzwa, izifo zesimila, kanye ne-tissue necrosis nazo ziholela ekwandeni kwe-D-dimer; ngaphezu kwalokho, ezinye izifo zokuzivikela komzimba kubantu, njenge-rheumatic endocarditis, i-rheumatoid arthritis, i-systemic Lupus erythematosus, njll., nazo zingabangela ukwanda kwe-D-dimer.

Ngaphezu kokuxilonga izifo, ukutholwa kwe-D-dimer ngobuningi kungabonisa ngobuningi umphumela we-thrombolytic wemithi emtholampilo. Izici zezifo, njll., zonke ziyasiza.

Uma kwenzeka i-D-dimer ephezulu, umzimba usengozini enkulu ye-thrombosis. Ngalesi sikhathi, isifo esiyinhloko kufanele sitholakale ngokushesha okukhulu, futhi uhlelo lokuvimbela i-thrombosis kufanele luqalwe ngokuya ngesilinganiso se-DVT. Eminye imithi ingakhethwa yokwelapha ukuvimbela ukujiya kwegazi, njengokujova ngaphansi kwesikhumba se-heparin calcium enesisindo esiphansi sama-molecule noma i-rivaroxaban, enomthelela othile wokuvimbela ekwakhekeni kwe-thrombosis. Labo abanezilonda ze-thrombotic badinga i-thrombolytic tumor ngokushesha okukhulu, futhi babuyekeze i-D-dimer njalo.