I-D-dimer isuka kwi-cross-linked fibrin clot enyibilikiswe yi-plasmin. Ibonakalisa kakhulu umsebenzi we-lytic we-fibrin. Isetyenziswa kakhulu ekuxilongweni kwe-venous thromboembolism, i-deep vein thrombosis kunye ne-pulmonary embolism kwindlela yokusebenza yeklinikhi. Uvavanyo lomgangatho we-D-dimer alunawo, ukuba uvavanyo lobungakanani kufuneka lube ngaphantsi kwe-200μg/L.

Iziphumo zovavanyo ezikhulayo ze-D-dimer okanye ezibonisa ukuba zilungile zihlala zibonwa kwizifo ezinxulumene ne-hyperfibrinolysis yesibini, ezifana ne-hypercoagulable state, i-disseminated intravascular coagulation, isifo sezintso, ukwaliwa kokufakelwa kwamalungu omzimba, kunye nonyango lwe-thrombolytic. Ukongeza, xa kukho i-activated thrombosis kwimithambo yegazi yomzimba, okanye izifo ezihamba nomsebenzi we-fibrinolytic, i-D-dimer nayo iya kwanda kakhulu. Izifo eziqhelekileyo ezifana ne-myocardial infarction, i-pulmonary embolism, i-lower end deep vein thrombosis, i-cerebral infarction njl.njl.; ezinye izifo, utyando, izifo ze-tumor, kunye ne-tissue necrosis nazo zikhokelela ekwandeni kwe-D-dimer; ukongeza, ezinye izifo zokuzikhusela komzimba ebantwini, ezifana ne-rheumatic endocarditis, i-rheumatoid arthritis, i-systemic Lupus erythematosus, njl.njl., nazo zinokubangela ukwanda kwe-D-dimer.

Ukongeza ekuxilongeni izifo, ukufumanisa ubungakanani be-D-dimer kunokubonakalisa ubungakanani bempembelelo ye-thrombolytic yamayeza kunyango. Iinkalo zezifo, njl.njl., zonke ziluncedo.

Kwimeko ye-D-dimer ephezulu, umzimba usemngciphekweni omkhulu we-thrombosis. Ngeli xesha, isifo esiphambili kufuneka sichongwe ngokukhawuleza, kwaye inkqubo yokuthintela i-thrombosis kufuneka iqalwe ngokwe-DVT score. Amanye amayeza anokukhethwa kunyango lokuthintela ukujiya kwegazi, njengokufakwa kwe-subcutaneous ye-heparin calcium ephantsi kobunzima be-molecular okanye i-rivaroxaban, enefuthe elithile lokuthintela ekwakhiweni kwe-thrombosis. Abo banezilonda ze-thrombotic kufuneka bathathe i-thrombolytic tumor ngokukhawuleza ngexesha elifanelekileyo, kwaye baphinde bahlole i-D-dimer rhoqo.