Isibindi siyindawo yokudibanisa izinto ezahlukeneyo ze-coagulation, kwaye inokudibanisa kwaye ingasebenzi i-fibrin lysates kunye ne-antifibrinolytic substances, kwaye idlale indima yokulawula ekugcineni ibhalansi eguquguqukayo ye-coagulation kunye ne-anticoagulation system.Ukufunyanwa kwezalathisi ze-blood coagulation indexes kwizigulane ezine-hepatitis B zibonise ukuba akukho mmahluko omkhulu kwi-PTAPTT kwizigulane ezine-hepatitis B engapheliyo xa kuthelekiswa neqela eliqhelekileyo lokulawula (P> 0.05), kodwa kukho umehluko omkhulu kwi-FIB (P <0.05) ).Kwakukho ukungafani okuphawulekayo kwi-PT, i-APTT, kunye ne-FIB phakathi kweqela elinzima le-hepatitis B kunye neqela eliqhelekileyo lokulawula (P <005P <0.01), elibonisa ukuba ubunzima be-hepatitis B buhambelana ngokufanelekileyo kunye nokunciphisa amanqanaba e-coagulation factor factor.

Uhlalutyo lwezizathu zezi ziphumo zingentla:

1. Ngaphandle kwe-factor IV (Ca *) kunye ne-cytoplasm, ezinye izinto ze-plasma coagulation zenziwa kwisibindi;izinto ze-anticoagulation (i-coagulation inhibitors) ezifana ne-ATIPC, i-2-MaI-AT, njl njl. nazo zenziwe ngesibindi.ukuhlanganiswa kweeseli.Xa iiseli zesibindi zonakalisiwe okanye i-necrotic kwiidigri ezahlukeneyo, ukukwazi kwesibindi ukudibanisa izinto ze-coagulation kunye nezinto ezichasene ne-coagulation ziyancitshiswa, kwaye amanqanaba e-plasma yale miba nawo ayancitshiswa, okubangela imiqobo kwindlela yokudibanisa.I-PT luvavanyo lokuhlola inkqubo ye-coagulation yangaphandle, engabonakalisa inqanaba, umsebenzi kunye nomsebenzi we-coagulation factor IV VX kwi-plasma.Ukunciphisa le miba ingentla okanye utshintsho kwimisebenzi yabo kunye nemisebenzi ibe sesinye sezizathu ze-PT ixesha elide kwizigulane ezine-post-hepatitis B ye-cirrhosis kunye ne-hepatitis B enzima. izinto esibindini.

2. Ngakolunye uhlangothi, ngomonakalo weeseli zesibindi kunye nokungaphumeleli kwesibindi kwizigulane ze-hepatitis B, izinga le-plasmin kwi-plasma landa ngeli xesha.I-Plasmin ayinakukwazi ukwenza i-hydrolyze kuphela inani elikhulu le-fibrin, i-fibrinogen kunye nezinto ezininzi zokudibanisa ezifana nokuqeqeshwa kwezinto, i-XXX, i-VVII,Ⅱ, njl., kodwa kwakhona kudla isixa esikhulu sezinto ezichasene ne-coagulation ezifana ne-ATⅢPC kunye nokunye.Ngoko ke, ngokunzulu kwesi sifo, i-APTT yanda kwaye i-FIB yehla kakhulu kwizigulane ze-hepatitis B.

Ukuqukumbela, ukufunyaniswa kwezalathisi ze-coagulation ezifana ne-PTAPTTFIB kubaluleke kakhulu ukubaluleka kweklinikhi yokugweba imeko yezigulane ezine-hepatitis B engapheliyo, kwaye isalathisi esinovakalelo nesithembekileyo.