Isibindi yindawo yokwenza izinto ezahlukeneyo ezibangela ukujiya kwegazi, kwaye sinokudibanisa size sivale ii-fibrin lysates kunye nezinto ezilwa ne-fibrinolytic, kwaye sidlala indima yokulawula ekugcineni ibhalansi eguquguqukayo yenkqubo yokujiya kwegazi kunye neyokuthintela ukujiya kwegazi. Ukufunyanwa kwee-index ze-blood coagulation kwizigulane ezine-hepatitis B kubonise ukuba akukho mahluko ubalulekileyo kwi-PTAPTT kwizigulane ezine-hepatitis B engapheliyo xa kuthelekiswa neqela lolawulo eliqhelekileyo (P>0.05), kodwa kukho umahluko obalulekileyo kwi-FIB (P<0.05). Kwakukho umahluko obalulekileyo kwi-PT, APTT, kunye ne-FIB phakathi kweqela le-hepatitis B elinzima kunye neqela lolawulo eliqhelekileyo (P<005P<0.01), nto leyo eyabonisa ukuba ubunzima be-hepatitis B bunxulumene kakuhle nokunciphisa amanqanaba e-blood coagulation factor.

Uhlalutyo lwezizathu zeziphumo ezingasentla:

1. Ngaphandle kwe-factor IV (Ca*) kunye ne-cytoplasm, ezinye izinto ezibangela ukujiya kwe-plasma ziyaveliswa esibindini; izinto ezibangela ukujiya kwe-plasma (izithinteli zokujiya kwe-plasma) ezifana ne-ATIPC, i-2-MaI-AT, njl.njl. nazo zenziwa yi-liver. cell synthesis. Xa iiseli zesibindi zonakele okanye zifile ngamanqanaba ahlukeneyo, amandla esibindi okwenza izinto ezibangela ukujiya kwe-plasma kunye nezinto ezibangela ukujiya kwe-plasma ayancitshiswa, kwaye amanqanaba e-plasma ezi zinto nawo ayancitshiswa, nto leyo ebangela imiqobo kwindlela yokujiya kwe-plasma.I-PT luvavanyo lokuhlola inkqubo yokuxinana kwamalungu omzimba yangaphandle, olunokubonakalisa inqanaba, umsebenzi kunye nomsebenzi we-coagulation factor IV VX kwi-plasma. Ukuncipha kwezi zinto zingasentla okanye utshintsho kwimisebenzi yazo kuye kwaba yenye yezizathu ze-PT ende kwizigulane ezine-post-hepatitis B cirrhosis kunye ne-hepatitis B enzima. Ke ngoko, i-PT isetyenziswa rhoqo eklinikhi ukubonisa ukwenziwa kwezinto zokuxinana kwamalungu omzimba esibindini.

2. Kwelinye icala, ngomonakalo weeseli zesibindi kunye nokungasebenzi kakuhle kwesibindi kwizigulane ezine-hepatitis B, inqanaba le-plasmin kwi-plasma liyanda ngeli xesha. I-Plasmin ayinakukwazi kuphela ukunyibilikisa inani elikhulu le-fibrin, i-fibrinogen kunye nezinye izinto ezininzi ezibangela ukujiya kwegazi ezifana noqeqesho lwezinto, i-XXX, i-VVII,Ⅱ, njl., kodwa ikwasebenzisa inani elikhulu lezinto ezilwa nokujiya kwegazi ezifana ne-ATⅢPC njalo njalo. Ngoko ke, njengoko esi sifo sikhula, i-APTT yaqhubeka ixesha elide kwaye i-FIB yehla kakhulu kwizigulane ezine-hepatitis B.

Ukuqukumbela, ukufunyanwa kwee-coagulation indexes ezifana ne-PTAPTTFIB kubaluleke kakhulu kwiklinikhi ekugwebeni imeko yezigulane ezine-hepatitis B engapheliyo, kwaye luphawu lokufumanisa olunobuthathaka noluthembekileyo.