D-dimer imachokera ku cross-linked fibrin clot yomwe imasungunuka ndi plasmin. Imasonyeza makamaka ntchito ya lytic ya fibrin. Imagwiritsidwa ntchito makamaka pozindikira venous thromboembolism, deep vein thrombosis ndi pulmonary embolism muzochitika zachipatala. Mayeso a D-dimer ndi oipa, ngati mayeso ochulukitsa ayenera kukhala ochepera 200μg/L.

Kuwonjezeka kwa D-dimer kapena zotsatira zabwino za mayeso nthawi zambiri zimawoneka m'matenda okhudzana ndi hyperfibrinolysis yachiwiri, monga mkhalidwe wa hypercoagulable, kugawanika kwa magazi m'mitsempha, matenda a impso, kukana kuikidwa kwa ziwalo, ndi chithandizo cha thrombolytic. Kuphatikiza apo, pakakhala thrombosis yoyambitsidwa m'mitsempha yamagazi ya thupi, kapena matenda otsagana ndi ntchito ya fibrinolytic, D-dimer imawonjezekanso kwambiri. Matenda ofala monga myocardial infarction, pulmonary embolism, lower end deep vein thrombosis, cerebral infarction Etc.; matenda ena, opaleshoni, matenda otupa, ndi necrosis ya minofu zimapangitsanso kuwonjezeka kwa D-dimer; kuphatikiza apo, matenda ena a autoimmune a anthu, monga rheumatic endocarditis, rheumatic arthritis, systemic Lupus erythematosus, ndi zina zotero, angayambitsenso kuwonjezeka kwa D-dimer.

Kuwonjezera pa kuzindikira matenda, kuzindikira kuchuluka kwa D-dimer kungasonyezenso kuchuluka kwa zotsatira za mankhwala m'matenda. Mbali za matenda, ndi zina zotero, zonse zimathandiza.

Pankhani ya D-dimer yokwera, thupi limakhala pachiwopsezo chachikulu cha thrombosis. Pakadali pano, matenda oyamba ayenera kupezeka mwachangu momwe angathere, ndipo pulogalamu yopewera thrombosis iyenera kuyambika malinga ndi chiwerengero cha DVT. Mankhwala ena amatha kusankhidwa kuti agwiritsidwe ntchito pochiza magazi kuundana, monga jakisoni wa heparin calcium wolemera pang'ono kapena rivaroxaban, zomwe zimakhala ndi mphamvu yoteteza kupangika kwa thrombosis. Omwe ali ndi zilonda za thrombosis amafunika kuchiza chotupa cha thrombolytic mwachangu momwe zingathere mkati mwa nthawi yabwino, ndipo nthawi ndi nthawi werengani D-dimer.