Gịnị mere e jikwa eji tubes serum achọpụta ọdịnaya D-dimer? A ga-enwe usoro fibrin clot na tube serum, ọ̀ bụ na ọ gaghị agbaze ka ọ bụrụ D-dimer? Ọ bụrụ na ọ gbazeghị agbaze, gịnị kpatara e ji enwe mmụba dị ukwuu na D-dimer mgbe e mepụtara skru ọbara na tube anticoagulation n'ihi na a naghị eji ọbara eme ihe nke ọma maka ule coagulation?
Nke mbụ, nchịkọta ọbara na-adịghị mma nwere ike ibute mmebi endothelial vascular, yana mwepụta nke subendothelial tissue factor na plasminogen activator (tPA) n'ime ọbara. N'otu aka, ihe na-eme ka usoro coagulation nke exogenous rụọ ọrụ iji mepụta mkpọchi fibrin. Usoro a dị ngwa ngwa. Lelee oge prothrombin (PT) ka ịmara, nke na-ewekarị ihe dị ka sekọnd iri. N'aka nke ọzọ, mgbe e guzobere fibrin, ọ na-arụ ọrụ dị ka ihe na-eme ka ọrụ tPA dịkwuo elu ugboro 100, mgbe e jikọtakwara tPA na elu fibrin, plasminogen activation inhibitor-1 (PAI-1) agaghịzi egbochi ya ngwa ngwa. Ya mere, enwere ike ịgbanwe plasminogen ngwa ngwa na mgbe niile ka ọ bụrụ plasmin, wee nwee ike imebi fibrin, enwere ike ịmepụta nnukwu FDP na D-Dimer. Nke a bụ ihe kpatara mmepụta nke ọbara clotting in vitro na fibrin degeneration products ji amụba nke ukwuu n'ihi na ọ naghị arụ ọrụ nke ọma.
Mgbe ahụ, gịnị mere nchịkọta nkịtị nke tube serum (na-enweghị ihe mgbakwunye ma ọ bụ na coagulant) ji mepụta fibrin clots in vitro, mana ha emebighị iji mepụta nnukwu FDP na D-dimer? Nke a dabere na tube serum. Gịnị mere mgbe anakọtachara ihe nlele ahụ: Nke mbụ, enweghị nnukwu tPA na-abanye n'ọbara; nke abụọ, ọbụlagodi na obere tPA abanye n'ọbara, PAI-1 ga-ejikọ tPA efu ma tụfuo ọrụ ya n'ime ihe dị ka nkeji ise tupu ọ banye na fibrin. N'oge a, ọtụtụ mgbe, a naghị enwe usoro fibrin na tube serum na-enweghị ihe mgbakwunye ma ọ bụ na coagulant. Ọ na-ewe ihe karịrị nkeji iri ka ọbara na-enweghị ihe mgbakwunye iji chịkọta onwe ya, ebe ọbara nwere coagulant (na-abụkarị ntụ silicon) na-amalite n'ime. Ọ na-ewekwa ihe karịrị nkeji ise iji mepụta fibrin site na ụzọ coagulation ọbara. Na mgbakwunye, ọrụ fibrinolytic na okpomọkụ ụlọ in vitro ga-emetụtakwa.
Ka anyị kwuo maka thromboelastogram ọzọ n'isiokwu a: ị nwere ike ịghọta na ọbara ọgbụgba dị na tube serum anaghị emebi ngwa ngwa, ị nwekwara ike ịghọta ihe kpatara ule thromboelastogram (TEG) anaghị enwe mmetụta iji gosipụta hyperfibrinolysis - ọnọdụ abụọ ahụ. N'ezie, ọ dị ka nke ahụ, enwere ike idobe okpomọkụ n'oge ule TEG na ogo 37. Ọ bụrụ na TEG nwere mmetụta karịa igosipụta ọnọdụ fibrinolysis, otu ụzọ bụ ịgbakwunye tPA na nnwale TEG in vitro, mana enwere nsogbu nhazi ka dị ma enweghị ngwa zuru ụwa ọnụ; na mgbakwunye, enwere ike ịtụ ya n'akụkụ akwa ozugbo a nwalechara ya, mana mmetụta ahụ dịkwa oke oke. Nnwale ọdịnala na nke dị irè karị maka ịtụle ọrụ fibrinolytic bụ oge mgbaze nke euglobulin. Ihe kpatara mmetụta ya dị elu karịa nke TEG. N'ule ahụ, a na-ewepụ anti-plasmin site na ịhazi uru pH na centrifugation, mana ule ahụ na-eri ya. Ọ na-ewe ogologo oge ma dị nro, a naghịkwa eme ya na ụlọ nyocha.
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