Ukubaluleka Okuyinhloko Kokuxilongwa Kwe-Coagulation


Umbhali: Olandelayo   

Ukuxilongwa kwe-coagulation ikakhulukazi kuhlanganisa isikhathi se-plasma prothrombin (PT), isikhathi se-prothrombin esiyingxenye esicushiwe (APTT), i-fibrinogen (FIB), isikhathi se-thrombin (TT), i-D-dimer (DD), i-International Standardization Ratio (INR).

I-PT: Ibonisa ngokuyinhloko isimo sesistimu ye-extrinsic coagulation, lapho i-INR ivame ukusetshenziselwa ukuqapha ama-anticoagulants omlomo.Ukwelulwa kubonakala ku-congenital coagulation factor ⅡⅤⅦⅩ ukuntula kanye nokuntuleka kwe-fibrinogen, futhi ukuntuleka kwe-coagulation factor etholwe kubonakala ikakhulukazi ekuntulekeni kwe-vitamin K, isifo esibi sesibindi, i-hyperfibrinolysis, i-DIC, ama-anticoagulants omlomo, njll.;ukufinyeza kubonakala esimweni segazi se-hypercoagulable kanye nesifo se-thrombosis, njll.

I-APTT: Ikhombisa kakhulu isimo se-endogenous coagulation system, futhi ivamise ukusetshenziselwa ukuqapha umthamo we-heparin.Ukwenyuka kwe-plasma factor VIII, i-factor IX kanye ne-factor XI yehla amazinga: njenge-hemophilia A, i-hemophilia B kanye nokuntuleka kwe-factor XI;kwehle esimweni se-hypercoagulable: njengokungena kwezinto ze-procoagulant egazini kanye nomsebenzi owandayo we-coagulation factor, njll.

I-FIB: ikakhulukazi ibonisa okuqukethwe kwe-fibrinogen.Ukwenyuka kwe-acute myocardial infarction kanye nokwehla esikhathini sokuqedwa kwe-DIC consumptive hypocoagulable, i-fibrinolysis eyinhloko, i-hepatitis enzima, kanye ne-cirrhosis yesibindi.

I-TT: Ikhombisa kakhulu isikhathi lapho i-fibrinogen iguqulwa ibe yi-fibrin.Ukwanda kwabonakala esigabeni se-hyperfibrinolysis se-DIC, nge-fibrinogenemia ephansi (ayikho), i-hemoglobinemia engavamile, kanye nemikhiqizo yokuwohloka kwe-fibrin (fibrinogen) (FDP) egazini;ukuncipha kwakungekho ukubaluleka komtholampilo.

I-INR: I-International Normalized Ratio (INR) ibalwa kusukela esikhathini se-prothrombin (PT) kanye ne-International Sensitivity Index (ISI) ye-assay reagent.Ukusetshenziswa kwe-INR kwenza i-PT ilinganiswe ngamalabhorethri ahlukene nama-reagents ahlukene aqhathaniswe, okwenza kube lula ukuhlangana kwamazinga ezidakamizwa.

Ukubaluleka okuyinhloko kokuhlolwa kwegazi ezigulini kuwukuhlola ukuthi ayikho yini inkinga ngegazi, ukuze odokotela bakwazi ukusiqonda isimo sesiguli ngesikhathi, futhi kuba lula ngodokotela ukuba baphuze imithi efanele nokwelashwa.Usuku olungcono kakhulu lwesiguli sokwenza izivivinyo ezinhlanu ze-coagulation lisesiswini esingenalutho, ukuze imiphumela yokuhlolwa izonemba kakhudlwana.Ngemuva kokuhlolwa, isiguli kufanele sibonise imiphumela yokuhlolwa kudokotela ukuze athole izinkinga zegazi futhi avimbele izingozi eziningi.