1. Ukuhlolwa kwe-Plasma D-dimer kuyindlela yokuhlola ukuqonda umsebenzi wesibili we-fibrinolytic.

Isimiso sokuhlola: I-antibody ye-anti-DD monoclonal imbozwe ezinhlayiyeni ze-latex. Uma kukhona i-D-dimer ku-plasma ye-receptor, kuzokwenzeka ukusabela kwe-antigen-antibody, futhi izinhlayiya ze-latex zizohlangana. Kodwa-ke, lokhu kuhlolwa kungaba nomphumela omuhle kunoma yikuphi ukopha okwakheka kwe-blood clot, ngakho-ke kunokucacile okuphansi kanye nokuzwela okuphezulu.

2. Kunemithombo emibili ye-D-dimer in vivo

(1) Isimo sokujiya kwegazi kanye ne-hyperfibrinolysis yesibili;

(2) ukususwa kwe-thrombosis;

I-D-dimer ikhombisa kakhulu umsebenzi we-fibrinolytic. Ukwanda noma okuhle kubonakala ku-hyperfibrinolysis yesibili, njengesimo se-hypercoagulable, ukujiya kwemithambo yegazi okusabalele, isifo sezinso, ukwenqatshwa kokufakelwa kwezitho, ukwelashwa nge-thrombolytic, njll.

3. Uma nje kukhona i-thrombosis esebenzayo kanye nomsebenzi we-fibrinolytic emithanjeni yegazi yomzimba, i-D-dimer izokhula.

Isibonelo: i-myocardial infarction, i-cerebral infarction, i-pulmonary embolism, i-venous thrombosis, ukuhlinzwa, i-tumor, i-dissembled intravascular coagulation, ukutheleleka kanye ne-tissue necrosis kungaholela ekwandeni kwe-D-dimer. Ikakhulukazi kubantu asebekhulile kanye neziguli ezilaliswe esibhedlela, ngenxa ye-bacteremia nezinye izifo, kulula ukubangela ukujiya kwegazi okungavamile futhi kuholele ekwandeni kwe-D-dimer.

4. Ukucaca okuboniswa yi-D-dimer akubhekiseli ekusebenzeni kwesifo esithile esithile, kodwa ezicini ezivamile ze-pathological zaleli qembu elikhulu lezifo ezine-coagulation kanye ne-fibrinolysis.

Ngokwethiyori, ukwakheka kwe-cross-linked fibrin kuyi-thrombosis. Kodwa-ke, kunezifo eziningi zezokwelapha ezingase zisebenze uhlelo lokujiya ngesikhathi sokuvela nokukhula kwalesi sifo. Lapho kukhiqizwa i-cross-linked fibrin, uhlelo lwe-fibrinolytic luzosebenza futhi i-cross-linked fibrin izoncishiswa ukuze kuvinjelwe "ukunqwabelana" kwayo okukhulu (i-thrombus ebalulekile ngokwezokwelapha), okuholela ekuphakameni okukhulu kwe-D-dimer. Ngakho-ke, i-D-dimer ephezulu akuyona ngempela i-thrombosis ebalulekile ngokwezokwelapha. Kwezinye izifo noma kubantu ngabanye, kungaba inqubo ye-pathological.