1. Uvavanyo lwePlasma D-dimer luvavanyo lokuqonda umsebenzi wesibini we-fibrinolytic.

Umgaqo wokuhlola: I-anti-DD monoclonal antibody igqunywe kwii-latex particles. Ukuba kukho i-D-dimer kwi-receptor plasma, kuya kwenzeka i-antigen-antibody reaction, kwaye ii-latex particles ziya kuhlangana. Nangona kunjalo, olu vavanyo lunokuba nobungqina bokuba kukho nakuphi na ukopha okubangelwa kukwakheka kwe-blood clot, ngoko ke lunobuncinci obucacileyo kunye novakalelo oluphezulu.

2. Kukho imithombo emibini ye-D-dimer kwi-vivo

(1) Imeko yokuxinana kwegazi kunye ne-hyperfibrinolysis yesibini;

(2) ukususwa kwe-thrombosis;

I-D-dimer ibonakalisa kakhulu umsebenzi we-fibrinolytic. Ukwanda okanye ukulunga kubonakala kwi-hyperfibrinolysis yesibini, efana ne-hypercoagulable state, i-disseminated intravascular coagulation, isifo sezintso, ukwaliwa kokufakelwa kwamalungu omzimba, unyango lwe-thrombolytic, njl.njl.

3. Logama nje kukho i-thrombosis esebenzayo kunye nomsebenzi we-fibrinolytic kwimithambo yegazi yomzimba, i-D-dimer iya kwanda.

Umzekelo: i-myocardial infarction, i-cerebral infarction, i-pulmonary embolism, i-venous thrombosis, utyando, i-tumor, i-dissemed intravascular coagulation, usulelo kunye ne-tissue necrosis kunokukhokelela ekwandeni kwe-D-dimer. Ingakumbi kubantu abadala kunye nabagulayo esibhedlele, ngenxa ye-bacteremia kunye nezinye izifo, kulula ukubangela ukujiya kwegazi okungaqhelekanga kwaye kukhokelele ekwandeni kwe-D-dimer.

4. Ukuchaneka okubonakaliswa yi-D-dimer akubhekiseli ekusebenzeni kwisifo esithile, kodwa kwiimpawu eziqhelekileyo zesifo sale qela likhulu lezifo ezinokuxinana kwegazi kunye ne-fibrinolysis.

Ngokwethiyori, ukwakheka kwe-cross-linked fibrin yi-thrombosis. Nangona kunjalo, kukho izifo ezininzi zonyango ezinokuvuselela inkqubo yokujiya kwegazi ngexesha lokuvela nokukhula kwesi sifo. Xa i-cross-linked fibrin iveliswa, inkqubo ye-fibrinolytic iya kusebenza kwaye i-cross-linked fibrin iya kufakelwa i-hydrolyzed ukuthintela "ukuqokelelwa" kwayo okukhulu. (i-thrombosis ebalulekileyo ngokwezonyango), nto leyo ekhokelela kwi-D-dimer ephezulu kakhulu. Ke ngoko, i-D-dimer ephezulu ayisiyongxaki ye-thrombosis ebalulekileyo ngokwezonyango. Kwezinye izifo okanye kubantu ngabanye, isenokuba yinkqubo ye-pathological.