(1) D-dimer
Hei hua pirau o te fibrin whakawhiti-hono, he tohu noa te D-dimer e whakaatu ana i te whakahohenga toto toto me te hyperfibrinolysis tuarua. I roto i ngā tūroro COVID-19, he tohu nui ngā taumata D-dimer teitei mō ngā mate toto toto pea. He hononga tata hoki ngā taumata D-dimer ki te kaha o te mate, ā, he kino ake te matapae o ngā tūroro he nui te pikinga o te D-dimer i te whakaurunga. E taunaki ana ngā aratohu mai i te International Society of Thrombosis and Hemostasis (ISTH) kia waiho he D-dimer tino teitei (neke atu i te 3, 4 rānei ngā wā o te rohe o runga o te tikanga) hei tohu mō te whakaurunga ki te hōhipera i ngā tūroro COVID-19, i muri i te tango i ngā contraindications. Me hoatu wawe tonu te Anticoagulation me ngā horopeta ārai o te heparin taumaha-iti-ngota ki aua tūroro. Ina piki haere te D-dimer, ā, he nui te whakapae mō te thrombosis venous, te microvascular embolism rānei, me whakaaro ki te anticoagulation me ngā horopeta rongoā o te heparin.

Ahakoa ko te D-dimer teitei ake pea e tohu ana i te hyperfibrinolysis, he mea onge te toto i roto i ngā tūroro COVID-19 me te D-dimer teitei rawa atu mēnā ka neke whakamua ki te wāhanga hypocoagulable DIC e kitea ana, e tohu ana kei te aukati tonu te pūnaha fibrinolytic o te COVID-19 o te -19. Ko tētahi atu tohu e pā ana ki te fibrin, arā, ko te ia o te huringa o te taumata FDP me te taumata D-dimer he rite tonu.

 

(2) PT
Ko te PT roa he tohu anō hoki mō ngā mate toto toto pea i roto i ngā tūroro COVID-19, ā, kua whakaaturia he hononga ki te matapae kino. I te wāhanga tōmua o te mate toto toto i roto i te COVID-19, ko ngā tūroro he PT he noa, he āhua rerekē rānei, ā, ko te PT roa i roto i te wā toto totoka nui e tohu ana i te whakahohenga me te kai o ngā mea toto totoka o waho, me te puhoi o te polymerization fibrin, nō reira he ārai anticoagulation anō hoki. tētahi o ngā tohu. Heoi, ina roa ake te PT, inā koa ka puta ngā tohu toto i te tūroro, e tohu ana kua uru te mate toto totoka ki te wāhanga toto totoka iti, kua uaua rānei te tūroro nā te koretake o te ate, te korenga o te huaora K, te nui rawa o te anticoagulant, me ētahi atu, ā, me whakaaro ki te whakawhiti toto. Maimoatanga rerekē. Ko tētahi atu mea tirotiro toto totoka, te wā thromboplastin wāhanga whakahohe (APTT), ka mau tonu i te nuinga o te wā ki te taumata noa i te wā toto totoka nui o ngā mate toto totoka, ka taea te kī ko te pikinga o te tauhohenga o te mea VIII i roto i te āhua mumura.

 

(3) Te tatau o ngā pereti toto me te whakamātautau mahi
Ahakoa ka taea e te whakahohenga o te toto toto te arahi ki te whakahekenga o te kai pereti toto, he mea onge te whakahekenga o te maha o ngā pereti toto i roto i ngā tūroro COVID-19, e pā ana pea ki te pikinga o te tukunga o te thrombopoietin, IL-6, ngā cytokines e whakatairanga ana i te uruparenga o ngā pereti toto i roto i ngā āhua mumura. Nō reira, ehara te uara tuturu o te maha o ngā pereti toto i te tohu tairongo e whakaatu ana i ngā mate toto toto i roto i te COVID-19, ā, he mea nui ake pea te aro ki ōna huringa. Hei tāpiri, he hononga nui te whakahekenga o te maha o ngā pereti toto ki te matapae kino, ā, ko tētahi hoki o ngā tohu mō te ārai toto toto. Heoi, ina tino heke te maha (hei tauira, <50×109/L), ā, he tohu toto kei te tūroro, me whakaaro ki te whakawhiti wāhanga pereti toto.

He rite ki ngā hua o ngā rangahau o mua i roto i ngā tūroro e pangia ana e te sepsis, he iti noa ngā hua o ngā whakamātautau mahi pereti toto in vitro i roto i ngā tūroro COVID-19 e mate ana i te toto toto, engari he maha ngā wā ka whakahohehia ngā pereti toto tuturu i roto i ngā tūroro, e pā ana pea ki te iti o te mahi. Ko ngā pereti toto teitei ka whakamahia tuatahitia, ka pau hoki i te tukanga toto toto, ā, he iti te mahi whanaunga o ngā pereti toto i roto i te tohanga toto kua kohia.

 

(4) FIB
Hei pūmua tauhohenga wāhanga whakapeka, he maha ngā wā ka nui ake ngā taumata o te FIB i roto i ngā tūroro COVID-19 i te wāhanga whakapeka o te mate, ehara i te mea e pā ana ki te kaha o te mumura anake, engari ko te FIB kua tino piki ake he take mōrearea hoki mō te thrombosis, nō reira ka taea te whakamahi hei COVID-19. Ko tētahi o ngā tohu mō te anticoagulability i roto i ngā tūroro. Heoi, ina heke haere te FIB o te tūroro, tera pea he tohu kua neke haere te mate coagulability ki te wāhanga hypocoagulable, he ngoikore nui rānei te ate o te tūroro, e puta ana i te nuinga o te wā i te wāhanga whakamutunga o te mate, ina FIB <1.5 g/L me te haere tahi me te toto, me whakaaro ki te werohanga FIB.