(1) D-dimer
Sechigadzirwa chekushatisa chemuchinjiko-yakabatana fibrin, D-dimer chiratidzo chakajairika chinoratidza coagulation activation uye yechipiri hyperfibrinolysis.Mune varwere vane COVID-19, yakakwira D-dimer mazinga akakosha mucherechedzo wezvinogoneka coagulation kusagadzikana.D-dimer mazinga zvakare ane hukama zvakanyanya nekuoma kwechirwere, uye varwere vane yakanyanya kukwirisa D-dimer pakubvumidzwa vane fungidziro yakaipisisa.Nhungamiro kubva kuInternational Society yeThrombosis uye Hemostasis (ISTH) inokurudzira kuti D-dimer yakakwira zvakanyanya (kazhinji inodarika katatu kana mana nguva yepamusoro yezvakajairwa) inogona kuve chiratidzo chekuiswa muchipatara muvarwere veCCIDID-19, mushure mekubviswa kwezvinopesana. Anticoagulation ine prophylactic doses yeyakaderera-molecular-weight heparin inofanira kupiwa kuvarwere vakadaro nokukurumidza sezvinobvira.Kana D-dimer ichikwira zvishoma nezvishoma uye paine kufungirwa kwakanyanya kwevenous thrombosis kana microvascular embolism, anticoagulation nemishonga yekurapa yeheparin inofanirwa kutariswa.

Kunyangwe yakasimudzwa D-dimer inogona zvakare kuratidza hyperfibrinolysis, kubuda ropa muvarwere veCCIDID-19 vane yakakwira zvakanyanya D-dimer haina kujairika kunze kwekunge uchifambira mberi kune yakanyanyisa DIC hypocoagulable chikamu, zvichiratidza kuti COVID-19 Iyo fibrinolytic system ye-19 ichiri kunyanya kuvharwa.Chimwe chicherechedzo chine chekuita nefibrin, ndiko kuti, shanduko yeFDP level uye D-dimer level yaive yakafanana.

 

(2) PT
Yakareba PT zvakare chiratidzo chezvinobvira coagulation kusagadzikana muCOVID-19 varwere uye yakaratidzwa kuve yakabatana nekushomeka kwekufungidzira.Mukutanga nhanho yecoagulation kusagadzikana muCCIDID-19, varwere vane PT vanowanzojairika kana zvinyoro zvisizvo, uye iyo yakareba PT iri mu hypercoagulable nguva inowanzo ratidza mabatirwo uye manwiro eexogenous coagulation zvinhu, pamwe nekudzikira kwefibrin polymerization, saka zvakare inodzivirira anticoagulation.chimwe chezviratidzo.Zvisinei, apo PT inowedzera kureba zvakanyanya, kunyanya kana murwere ane zviratidzo zvekubuda ropa, zvinoratidza kuti chirwere chekugadzirisa chapinda muchikamu chepasi, kana murwere akaomeswa nekusakwana kwechiropa, kushaya vitamini K, anticoagulant overdose, nezvimwewo, uye Kuisirwa plasma kunofanira kutariswa.Alternative treatment.Imwe coagulation screening chinhu, activated partial thromboplastin time (APTT), inonyanya kuchengetedzwa pachiyero chakajairwa panguva ye hypercoagulable chikamu che coagulation kusagadzikana, izvo zvinogona kunge zvichikonzerwa nekuwedzera reactivity kwechinhu VIII munzvimbo yekuzvimba.

 

(3) Platelet count uye basa rekuedza
Kunyangwe activation yecoagulation inogona kutungamira mukudzikira kweplatelet kushandiswa, kuderera kweplatelet kuverenga hakuna kujairika muCOVID-19 varwere, izvo zvinogona kunge zvine hukama nekuwedzera kuburitswa kwethrombopoietin, IL-6, cytokines inokurudzira platelet reactivity munzvimbo dzekuzvimba Naizvozvo, kukosha kwakakwana kwe platelet count haisi chiratidzo chinotaridza chinoratidza coagulation kusagadzikana muCCIDID-19, uye zvingave zvakanyanya kukosha kutarisisa shanduko dzayo.Mukuwedzera, kuderera kweplatelet count kunobatanidza zvakanyanya nekushaya fungidziro uye zvakare chimwe chezviratidzo zveprophylactic anticoagulation.Zvisinei, kana nhamba yacho yakanyanya kuderedzwa (semuenzaniso, <50 × 109/L), uye murwere ane zviratidzo zvekubuda ropa, kuwedzerwa kweplatelet chikamu kunofanira kufungwa.

Zvakafanana nemhedzisiro yezvidzidzo zvakapfuura muvarwere vane sepsis, in vitro platelet function bvunzo muCOVID-19 varwere vane coagulation kusagadzikana kazhinji inoburitsa yakaderera, asi iwo chaiwo maplatelet muvarwere anowanzo itwa, izvo zvingave zvichikonzerwa nekuderera kwekuita.Maplatelet epamusoro anotanga kushandiswa uye kupedzwa neiyo coagulation process, uye hukama hwemaplatelet mukutenderera kwakaunganidzwa kwakadzikira.

 

(4) FIB
Seye acute phase reaction protein, varwere vane COVID-19 vanowanzova nemazinga akakwira eFIB muchikamu chetachiona chetachiona, icho chisinei nehutsinye hwekuzvimba, asi yakanyanya kukwidziridza FIB pachayo ingozi ye thrombosis, saka. inogona kushandiswa seCOVID-19 Imwe yezviratidzo zveanticoagulation muvarwere.Zvisinei, apo murwere ane kuderera kunofambira mberi muFIB, zvinogona kuratidza kuti chirwere chekugadzirisa chave chichienda kune hypocoagulable stage, kana kuti murwere ane chirwere chakanyanya chehepatic insufficiency, iyo inowanzoitika munguva yekupedzisira yechirwere, apo FIB <1.5 g / L uye ichiperekedzwa nekubuda ropa, FIB infusion inofanira kutariswa.