(1) D-dimer
Sechigadzirwa chekuora kwe fibrin yakabatana, D-dimer chiratidzo chinowanzo ratidza kushanda kwe coagulation uye secondary hyperfibrinolysis. Muvarwere vane COVID-19, mazinga eD-dimer akakwira chiratidzo chakakosha chezvirwere zvinogona kuitika zvekugwamba kweropa. Mazinga eD-dimer ane chekuitawo nekuoma kwechirwere, uye varwere vane D-dimer yakakwira zvakanyanya pavanopinda muchipatara vane fungidziro yakaipa. Nhungamiro kubva kuInternational Society of Thrombosis and Hemostasis (ISTH) inokurudzira kuti D-dimer yakakwira zvakanyanya (kazhinji kanopfuura katatu kana ka4 kupfuura muganho wepamusoro wenguva dzose) inogona kuva chiratidzo chekurapwa muchipatara muvarwere veCOVID-19, mushure mekubviswa kwezvirambidzo. Anticoagulation ne prophylactic doses ye low-molecular-weight heparin inofanira kupihwa kuvarwere vakadaro nekukurumidza sezvinobvira. Kana D-dimer yakwira zvishoma nezvishoma uye paine fungidziro yakakura ye venous thrombosis kana microvascular embolism, anticoagulation ne therapeutic doses ye heparin inofanira kufungwa nezvayo.

Kunyangwe D-dimer yakakwira inogonawo kuratidza hyperfibrinolysis, mukana wekubuda ropa muvarwere veCOVID-19 vane D-dimer yakakwira zvakanyanya hauwanzoitika kunze kwekunge vafambira mberi kusvika padanho reDIC risingagwambe, zvichiratidza kuti COVID-19 Sisitimu yefibrinolytic ye -19 ichiri kudziviswa zvakanyanya. Chimwe chiratidzo chine chekuita nefibrin, ndiko kuti, maitiro ekuchinja kweFDP level neD-dimer level aive akafanana.

 

(2) PT
Kuongororwa kwenguva refu kwePT chiratidzowo chezvirwere zvinogona kuomera muvarwere veCOVID-19 uye zvakaratidzwa kuti zvine chekuita nekufanotaura kwakashata. Pakutanga kwechirwere chekuomera muCOVID-19, varwere vane PT vanowanzova vakajairika kana kuti vasina kujairika, uye kuongororwa kwenguva refu kwePT munguva yekuomera kunowanzo ratidza kushanda uye kushandiswa kwezvinhu zvinoomera kuomera kunze, pamwe nekuderera kwe fibrin polymerization, saka zvakare inzira yekudzivirira kuomera kuomera. Chimwe chezviratidzo. Zvisinei, kana PT ikawedzerwa nguva zvakanyanya, kunyanya kana murwere aine zviratidzo zvekubuda ropa, zvinoratidza kuti chirwere chekuomera chapinda muchikamu chekuomera kushoma, kana kuti murwere akaomarara nekuda kwekushaya simba kwechiropa, kushomeka kwevhitamini K, overdose yeanticoagulant, nezvimwewo, uye kuwedzerwa ropa kunofanirwa kufungwa. Kurapa kumwe. Chimwe chinhu chekuongorora kuomera kuomera, activated partial thromboplastin time (APTT), inonyanya kuchengetedzwa padanho rakajairika panguva yekuomera kuomera kwezvirwere zvekuomera kuomera, izvo zvinogona kukonzerwa nekuwedzera kwe reactivity ye factor VIII mumamiriro ekuzvimba.

 

(3) Kuverengwa kwemaplatelet uye bvunzo yekushanda kwawo
Kunyangwe kuvhurwa kwekuvhara ropa kunogona kukonzera kudzikira kwekushandiswa kwemaplatelet, kudzikira kwehuwandu hwemaplatelet hakuna kujairika muvarwere veCOVID-19, izvo zvinogona kunge zvine chekuita nekubudiswa kwakawanda kwe thrombopoietin, IL-6, cytokines dzinokurudzira reactivity yemaplatelet muzvirwere zvinozvimba. Saka, kukosha kwakakwana kwehuwandu hwemaplatelet hakusi chiratidzo chinonzwisisika chinoratidza kusagadzikana kwekuvhara ropa muCOVID-19, uye zvingave zvakakosha kutarisisa shanduko dzayo. Pamusoro pezvo, kudzikira kwehuwandu hwemaplatelet kunobatanidzwa zvakanyanya nekufanotaura kusina kunaka uye ndeimwe yezviratidzo zvekudzivirira kuvhara ropa. Zvisinei, kana huwandu hwacho hwadzikira zvakanyanya (semuenzaniso, <50×109/L), uye murwere aine zviratidzo zvekubuda ropa, kuwedzerwa kwechikamu cheplatelet kunofanirwa kufungwa nezvacho.

Kufanana nemigumisiro yezvidzidzo zvekare muvarwere vane sepsis, bvunzo dzekushanda kwemaplatelet muropa muvarwere veCOVID-19 vane matambudziko ekugwamba kweropa dzinowanzo buritsa mhedzisiro yakaderera, asi maplatelet chaiwo muvarwere anowanzo shanda, izvo zvinogona kukonzerwa nekushanda kwakaderera. Maplatelet akakwira anotanga kushandiswa uye kudyiwa nemaitiro ekugwamba kweropa, uye kushanda kwemaplatelet muropa rakaunganidzwa kwakaderera.

 

(4) FIB
Seprotein ye acute phase reaction, varwere vane COVID-19 vanowanzova nemazinga akakwira eFIB muchikamu che acute chehutachiona, izvo zvisingangobatanidzwi nekuoma kwekuzvimba chete, asi zvakanyanya kukwira kweFIB pachayo inokonzerawo njodzi ye thrombosis, saka inogona kushandiswa seCOVID-19 Chimwe chezviratidzo zvekudzivirira kuungana kweropa muvarwere. Zvisinei, kana murwere aine kudzikira kuri kuramba kuchiita FIB, zvinogona kuratidza kuti chirwere chekuungana kweropa chasvika padanho re hypocoagulable, kana kuti murwere ane kusakwana kwechiropa kwakanyanya, izvo zvinonyanya kuitika muchikamu chekupedzisira chechirwere, apo FIB <1.5 g/L uye inoperekedzwa nekubuda ropa, kuisirwa kweFIB kunofanirwa kufungwa nezvako.