Kwabesifazane abakhulelwe abavamile, njengoba iminyaka yokukhulelwa ikhula, ukukhishwa kwenhliziyo kuyanda futhi ukumelana kwemithambo yegazi kuyancipha. Ngokuvamile kukholelwa ukuthi ukukhishwa kwenhliziyo kuqala ukwanda emavikini angu-8 kuya kwangu-10 okukhulelwa futhi kufinyelela esicongweni emavikini angu-32 kuya kwangu-34 okukhulelwa, ukwanda okungu-30% kuya ku-45% uma kuqhathaniswa nokungakhulelwa, futhi kugcina leli zinga kuze kube yilapho kubeletha. Ukwehla kokumelana kwemithambo yegazi kwangaphandle kunciphisa umfutho wegazi, kanti umfutho wegazi we-diastolic wehla kakhulu, kanti umehluko womfutho wegazi uyakhula. Kusukela emavikini angu-6 kuya kwangu-10 okukhulelwa, umthamo wegazi labesifazane abakhulelwe uyanda ngokwanda kweminyaka yokukhulelwa, futhi ukhuphuka cishe ngo-40% ekupheleni kokukhulelwa, kodwa ukwanda komthamo we-plasma kudlula kakhulu inani lamaseli abomvu egazi, i-plasma iyanda ngo-40% kuya ku-50%, kanti amaseli abomvu egazi ayanda ngo-10% kuya ku-15%. Ngakho-ke, ekukhulelweni okuvamile, igazi liyancishiswa, libonakala njengokuncipha kwe-viscosity yegazi, ukwehla kwe-hematocrit, kanye nokwanda kwesilinganiso se-erythrocyte sedimentation.

Izici zokujiya kwegazi Ⅱ, Ⅴ, VII, Ⅷ, IX, kanye Ⅹ zonke ziyanda ngesikhathi sokukhulelwa, futhi zingafinyelela izikhathi eziyi-1.5 kuya kwezingu-2.0 zokujwayelekile phakathi nokukhulelwa okuphakathi nokwephuzile, kanye nemisebenzi yezinto zokujiya Ⅺ kanye  yehla. I-Fibrinopeptide A, i-fibrinopeptide B, i-thrombinogen, i-platelet factor Ⅳ kanye ne-fibrinogen yanda kakhulu, kuyilapho i-antithrombin Ⅲ kanye ne-protein C kanye ne-protein S yehla. Ngesikhathi sokukhulelwa, isikhathi se-prothrombin kanye nesikhathi se-prothrombin esingaphelele esisebenzayo sifinyezwa, futhi okuqukethwe kwe-plasma fibrinogen kwanda kakhulu, okunganda kufike ku-4-6 g/L ku-trimester yesithathu, okungaphezu kuka-50% kunalokho esikhathini sokungakhulelwe. Ngaphezu kwalokho, i-plasminogen yanda, isikhathi sokuncibilika kwe-euglobulin sandiswa, futhi izinguquko zokujiya kanye nokujiya zenza umzimba ube sesimweni sokujiya okukhulu, okwakuzuzisa ekujiya okuphumelelayo ngemva kokuphazamiseka kwe-placenta ngesikhathi sokubeletha. Ngaphezu kwalokho, ezinye izici ezibangela ukujiya kwegazi ngesikhathi sokukhulelwa zifaka phakathi ukwanda kwe-cholesterol iyonke, ama-phospholipid kanye nama-triacylglycerols egazini, i-androgen kanye ne-progesterone ekhishwa yi-placenta kunciphisa umphumela wezinye izithiyo zokujiya kwegazi, i-placenta, i-uterine decidua kanye nama-embryo. Ukuba khona kwezinto ezibangela i-thromboplastin, njll., kungakhuthaza igazi ukuba libe sesimweni sokujiya kwegazi, futhi lolu shintsho luyanda ngokwanda kweminyaka yokukhulelwa. I-hypercoagulation ephakathi nendawo iyisilinganiso sokuvikela ngokomzimba, esizuzisa ukugcina ukufakwa kwe-fibrin emithanjeni, udonga lwesibeletho kanye ne-placental villi, kusiza ukugcina ubuqotho be-placenta futhi kwakha i-thrombus ngenxa yokususwa, futhi kusiza i-hemostasis esheshayo ngesikhathi nangemva kokubeletha. , kuyindlela ebalulekile yokuvimbela ukuphuma kwegazi ngemva kokubeletha. Ngesikhathi esifanayo sokujiya kwegazi, umsebenzi wesibili we-fibrinolytic uqala futhi ukususa i-thrombus emithanjeni ye-spiral yesibeletho kanye ne-venous sinuses futhi kusheshiswe ukuvuselelwa nokulungiswa kwe-endometrium.