Kufunika kwachipatala
Kwenikweni limatanthauza chimodzimodzi ndi nthawi yothira magazi, koma ndi mphamvu yogwira ntchito kwambiri. Njira zambiri zodziwira APTT zomwe zimagwiritsidwa ntchito pano zitha kukhala zachilendo pamene plasma coagulation factor ili yotsika kuposa 15% mpaka 30% ya mulingo wabwinobwino.
(1) Kutalikitsa kwa APTT: zotsatira za APTT zimakhala zazitali ndi masekondi 10 kuposa zomwe zimayesedwa bwino. APTT ndiye mayeso odalirika kwambiri owunikira kusowa kwa coagulation factor ndipo amagwiritsidwa ntchito kwambiri kupeza hemophilia yofatsa. Ngakhale kuti kuchuluka kwa factor Ⅷ: C kumatha kupezeka pansi pa 25% ya hemophilia A, kukhudzidwa ndi subclinical hemophilia (factor Ⅷ>25%) ndi onyamula hemophilia ndi koipa. Zotsatira zazitali zimawonekeranso mu factor Ⅸ (hemophilia B), Ⅺ ndi Ⅶ kusowa; pamene zinthu zotsutsana ndi coagulant m'magazi monga zoletsa coagulation factor kapena kuchuluka kwa heparin zikuwonjezeka, prothrombin, fibrinogen ndi factor V, kusowa kwa X kumatha kutalikitsidwa, koma kukhudzidwa kumakhala kofooka pang'ono; Kutalikitsa kwa APTT kumatha kuwonedwanso mwa odwala ena omwe ali ndi matenda a chiwindi, DIC, ndi kuchuluka kwa magazi osungidwa.
(2) Kufupika kwa APTT: kumawoneka mu DIC, mkhalidwe wa prethrombotic state ndi matenda a thrombotic steatomic.
(3) Kuyang'anira chithandizo cha heparin: APTT imakhudzidwa kwambiri ndi kuchuluka kwa heparin m'magazi, kotero ndi chizindikiro chowunikira cha labotale chomwe chimagwiritsidwa ntchito kwambiri pakadali pano. Pakadali pano, ziyenera kudziwika kuti zotsatira za muyeso wa APTT ziyenera kukhala ndi ubale wolunjika ndi kuchuluka kwa heparin m'magazi m'njira yochiritsira, apo ayi siziyenera kugwiritsidwa ntchito. Nthawi zambiri, panthawi ya chithandizo cha heparin, ndibwino kuti APTT ikhale ndi nthawi 1.5 mpaka 3.0 kuposa nthawi yanthawi zonse.
Kusanthula zotsatira
Kawirikawiri, APTT ndi PT zimagwiritsidwa ntchito ngati mayeso oyesa magazi kuti awone ngati magazi akuyenda bwino. Malinga ndi zotsatira za muyeso, pali zinthu zinayi zotsatirazi:
(1) APTT ndi PT zonse ndi zachibadwa: Kupatula anthu abwinobwino, zimangopezeka mu kusowa kwa FXIII kobadwa nako komanso kwachiwiri. Zopezeka zimapezekanso mu matenda oopsa a chiwindi, chotupa cha chiwindi, malignant lymphoma, leukemia, anti-factor XIII antibody, autoimmune anemia ndi pernicious anemia.
(2) APTT yayitali yokhala ndi PT yabwinobwino: Matenda ambiri otuluka magazi amayamba chifukwa cha zolakwika zomwe zimachitika m'njira yolumikizirana magazi. Monga hemophilia A, B, ndi kusowa kwa factor Ⅺ; pali ma antibodies a anti-factor Ⅷ, Ⅸ, Ⅺ m'magazi.
(3) APTT yachibadwa yokhala ndi PT yayitali: matenda ambiri otuluka magazi omwe amayamba chifukwa cha zolakwika mu njira yolumikizirana kwa magazi, monga kusowa kwa majini ndi kusowa kwa chinthu VII. Matenda omwe amapezeka amapezeka kwambiri mu matenda a chiwindi, DIC, ma antibodies a anti-factor VII m'magazi komanso mankhwala oletsa magazi kulowa m'magazi.
(4) APTT ndi PT zonse zimakhala zotalikirapo: matenda ambiri otuluka magazi omwe amayamba chifukwa cha zolakwika zomwe zimachitika m'njira yodziwika bwino yolumikizirana magazi, monga kusowa kwa majini ndi kusowa kwa chinthu X, V, II ndi I. Zomwe zimapezeka zimapezeka makamaka mu matenda a chiwindi ndi DIC, ndipo zinthu X ndi II zimatha kuchepetsedwa ngati mankhwala oletsa magazi akumwa agwiritsidwa ntchito. Kuphatikiza apo, ngati pali ma antibodies a anti-factor X, anti-factor V ndi anti-factor II m'magazi, zimatalikiranso moyenerera. Ngati heparin ikugwiritsidwa ntchito kuchipatala, zonse ziwiri za APTTT ndi PT zimatalikiranso moyenerera.