ʻO ke koʻikoʻi o ke kino
Loaʻa ka manaʻo like me ka manawa coagulation, akā me ka naʻau kiʻekiʻe.ʻO ka hapa nui o nā kaʻina hoʻoholo APTT i hoʻohana ʻia i kēia manawa hiki ke ʻano ʻino ke haʻahaʻa ke kumu coagulation plasma ma mua o 15% a 30% o ka pae maʻamau.
(1) APTT hoʻolōʻihi: ʻo ka hopena APTT he 10 kekona ka lōʻihi ma mua o ka mana maʻamau.ʻO APTT ka hōʻike hōʻike hōʻoia pono loa no ka hemahema o ka coagulation factor endogenous a hoʻohana nui ʻia e ʻike i ka hemophilia haʻahaʻa.ʻOiai ʻo ka helu Ⅷ: Hiki ke ʻike ʻia nā pae C ma lalo o 25% o ka hemophilia A, ʻaʻole maikaʻi ka naʻau o ka hemophilia subclinical (factor Ⅷ>25%) a ʻaʻole maikaʻi nā mea lawe hemophilia.ʻIke ʻia nā hopena lōʻihi ma ka helu Ⅸ (hemophilia B), Ⅺ a me Ⅶ hemahema;ke piʻi aʻe nā mea anticoagulant koko e like me ka coagulation factor inhibitors a i ʻole heparin pae, prothrombin, fibrinogen a me factor V, X deficiency pū kekahi Hiki ke hoʻolōʻihi ʻia, akā ʻilihune iki ka naʻau;Hiki ke ʻike ʻia ka hoʻolōʻihi ʻana o APTT i nā maʻi ʻē aʻe me ka maʻi ate, DIC, a me ka nui o ke koko panakō.
(2) APTT pōkole: ʻike ʻia ma DIC, ke kūlana prethrombotic a me ka maʻi thrombotic.
(3) Ka nānā ʻana i ka mālama ʻana i ka heparin: ʻIke loa ʻo APTT i ka neʻe ʻana o ka heparin plasma, no laila he mea hoʻohana nui ia i ka nānā ʻana i ka ʻikepili i kēia manawa.I kēia manawa, pono e hoʻomaopopo ʻia ʻo ka hopena o ke ana APTT pono e loaʻa i kahi pilina laina me ka pae plasma o ka heparin i ka pae therapeutic, inā ʻaʻole pono e hoʻohana.ʻO ka maʻamau, i ka wā o ka mālama ʻana i ka heparin, ʻoi aku ka maikaʻi o ka mālama ʻana i ka APTT ma 1.5 a 3.0 mau manawa ma mua o ka mana maʻamau.
Nānā hopena
Hoʻohana pinepine ʻia ʻo APTT a me PT e like me nā hoʻāʻo screening no ka hana coagulation koko.Wahi a nā hopena ana, aia ma kahi o ʻehā mau kūlana:
(1) He mea maʻamau ka APTT a me ka PT: Koe wale no ka poʻe maʻamau, ʻike wale ʻia i ka hemahema FXIII hoʻoilina a me ka lua.Loaʻa nā mea maʻamau i ka maʻi ate koʻikoʻi, ka maʻi ate, lymphoma malignant, leukemia, anti-factor XIII antibody, autoimmune anemia a me pernicious anemia.
(2) APTT lōʻihi me ka PT maʻamau: ʻO ka hapa nui o nā maʻi kahe koko ke kumu o nā hemahema i ke ala coagulation intrinsic.E like me ka hemophilia A, B, a me ka helu Ⅺ hemahema;aia nā anti-factor Ⅷ, Ⅸ, Ⅺ i loko o ke kahe koko.
(3) APTT maʻamau me ka PT lōʻihi: ʻo ka hapa nui o nā maʻi koko i hoʻokumu ʻia e nā hemahema i ke ala coagulation extrinsic, e like me ka genetic a me ka hemahema o ka helu VII.Loaʻa nā mea maʻamau i ka maʻi ate, DIC, anti-factor VII antibodies i ke kahe koko a me nā anticoagulants waha.
(4) Hoʻolōʻihi ʻia ka APTT a me ka PT: ʻo ka hapa nui o nā maʻi koko i hoʻokumu ʻia e nā hemahema i ke ala coagulation maʻamau, e like me ka genetic a me ka mea i loaʻa ʻole X, V, II a me I deficiency.ʻIke nui ʻia nā mea i loaʻa i ka maʻi ate a me DIC, a hiki ke hoʻemi ʻia nā kumu X a me II ke hoʻohana ʻia nā anticoagulants waha.Eia kekahi, inā he anti-factor X, anti-factor V a me anti-factor II antibodies i ke kahe koko, ua hoʻolōʻihi ʻia lākou e like me ia.Ke hoʻohana ʻia ka heparin ma ke kino, ua hoʻolōʻihi ʻia ʻo APTTT a me PT e like me ia.