Kedu ihe bụ ule coagulation aPTT?


Onye edemede: Onye nọchiri   

Oge thromboplastin na-arụ ọrụ (oge thromboplasting akụkụ na-arụ ọrụ, APTT) bụ ule nyocha maka nchọpụta nke "ụzọ intrinsic" coagulation factor ntụpọ, ma na-eji ugbu a maka coagulation factor therapy, heparin anticoagulant ọgwụgwọ nlekota oru, na nchọpụta nke lupus anticoagulant bụ isi ụzọ nke coagulation. Anti-phospholipid autoantibodies, ugboro ngwa ngwa ya bụ nke abụọ na PT ma ọ bụ ha nhata.

Mkpa ụlọ ọgwụ
N'ụzọ bụ isi, ọ nwere otu ihe ahụ dị ka oge coagulation, mana nwere mmetụta dị elu.Ọtụtụ n'ime ụzọ mkpebi APTT a na-eji ugbu a nwere ike bụrụ ihe na-adịghị mma mgbe ihe na-akpata coagulation plasma dị ala karịa 15% ruo 30% nke ọkwa nkịtị.
(1) APTT ịgbatị: nsonaazụ APTT bụ 10 sekọnd ogologo karịa nke njikwa nkịtị.APTT bụ ule nyocha kachasị ntụkwasị obi maka ụkọ ihe coagulation endogenous ma a na-ejikarị achọpụta hemophilia dị nro.Ọ bụ ezie na ihe kpatara Ⅷ: Enwere ike ịchọpụta ọkwa C n'okpuru 25% nke hemophilia A, mmetụta nke hemophilia subclinical (ihe Ⅷ> 25%) na ndị na-ebu hemophilia adịghị mma.A na-ahụkwa nsonaazụ ogologo oge na ihe Ⅸ (hemophilia B), Ⅺ na Ⅶ erughị eru;mgbe ihe ndị na-egbochi arịa ọbara dị ka coagulation factor inhibitors ma ọ bụ heparin na-abawanye, prothrombin, fibrinogen na factor V, erughi X nwekwara ike ịgbatị ogologo oge, mana mmetụta ahụ adịchaghị mma;A pụkwara ịhụ ogologo oge APTT na ndị ọrịa ndị ọzọ nwere ọrịa imeju, DIC, na nnukwu ọbara ọbara.
(2) Mkpirisi APTT: hụrụ na DIC, ọnọdụ prethrombotic na ọrịa thrombotic.
(3) Nyochaa ọgwụgwọ heparin: APTT na-enwe mmetụta nke ukwuu na ntinye nke heparin plasma, yabụ na ọ bụ nyocha nyocha ụlọ nyocha nke a na-ejikarị ugbu a.N'oge a, ekwesịrị ịmara na nsonaazụ nha APTT ga-enwerịrị njikọ kwụ ọtọ na mkpokọta heparin plasma na oke ọgwụgwọ, ma ọ bụghị ya, ekwesighi iji ya.N'ozuzu, n'oge ọgwụgwọ heparin, ọ bụ ihe amamihe dị na ya ịnọgide na-enwe APTT na 1.5 ruo 3.0 ugboro nke njikwa nkịtị.
Nyocha nsonaazụ
Na ụlọ ọgwụ, APTT na PT na-ejikarị dị ka nyocha nyocha maka ọrụ coagulation ọbara.Dabere na nsonaazụ nha, enwere ọnọdụ anọ ndị a:
(1) Ma APTT na PT bụ ihe nkịtị: Ewezuga ndị nkịtị, a na-ahụ ya na ụkọ FXIII eketa na nke abụọ.Ndị enwetara na-ahụkarị na ọrịa imeju siri ike, etuto imeju, lymphoma na-adịghị mma, leukemia, anti-factor XIII antibody, autoimmune anaemia na anaemia na-emebi emebi.
(2) APTT ogologo oge na PT nkịtị: Ọtụtụ n'ime nsogbu ọbara ọgbụgba na-akpata site na ntụpọ dị n'ime ụzọ coagulation dị n'ime.Dị ka hemophilia A, B na ụkọ ihe Ⅺ;enwere ihe mgbochi Ⅷ, Ⅸ, Ⅺ ọgwụ mgbochi ọrịa na mgbasa ọbara.
(3) Nkịtị APTT na PT ogologo oge: ọtụtụ nsogbu ọbara ọgbụgba kpatara nrụrụ na ụzọ coagulation extrinsic, dị ka mkpụrụ ndụ ihe nketa na enwetaghị ihe VII.Ndị enwetara na-ahụkarị na ọrịa imeju, DIC, anti-factor VII antibodies na mgbasa ọbara na ọgwụ mgbochi ọnụ.
(4) Ma APTT na PT na-adịte aka: ọtụtụ nsogbu ọbara ọgbụgba na-akpata site na ntụpọ na ụzọ coagulation nkịtị, dị ka mkpụrụ ndụ ihe nketa na ihe enwetara X, V, II na erughi m.A na-ahụkarị ndị enwetara na ọrịa imeju na DIC, yana ihe X na II nwere ike ibelata mgbe ejiri ọgwụ mgbochi ọnụ.Na mgbakwunye, mgbe enwere mgbochi-factor X, anti-factor V na anti-factor II antibodies na mgbasa ọbara, ha na-adị ogologo oge n'ihi ya.Mgbe a na-eji heparin na-agwọ ọrịa, ma APTTT na PT na-agbatị ogologo oge.