Mkpa ọgwụgwọ
N'ụzọ bụ isi, ọ pụtara otu ihe ahụ dị ka oge coagulation, mana ọ nwere nnukwu mmetụta. Ọtụtụ n'ime ụzọ nchọpụta APTT eji ugbu a nwere ike ịdị iche mgbe ihe na-akpata coagulation plasma dị ala karịa 15% ruo 30% nke ọkwa nkịtị.
(1) Mgbatị APTT: nsonaazụ APTT dị sekọnd iri karịa nke njikwa nkịtị. APTT bụ ule nyocha kachasị ntụkwasị obi maka enweghị coagulation factor endogenous ma a na-ejikarị ya achọpụta obere hemophilia. Ọ bụ ezie na ihe Ⅷ: Enwere ike ịchọpụta ọkwa C n'okpuru 25% nke hemophilia A, mmetụta nke hemophilia subclinical (ihe Ⅷ>25%) na ndị na-ebu hemophilia adịghị mma. A na-ahụkwa nsonaazụ ogologo oge na factor Ⅸ (hemophilia B), Ⅺ na Ⅶ adịghị mma; mgbe ihe ndị na-egbochi coagulation ọbara dị ka coagulation factor inhibitors ma ọ bụ ọkwa heparin na-abawanye, prothrombin, fibrinogen na factor V, X enweghịkwa ike ịgbatị ya, mana mmetụta ahụ adịghị mma; Enwere ike ịhụkwa ịgbatị APTT na ndị ọrịa ndị ọzọ nwere ọrịa imeju, DIC, na nnukwu ọbara a na-etinye n'ime akpa.
(2) Mkpụmkpụ APTT: a na-ahụ ya na DIC, ọnọdụ tupu thrombosis na ọrịa thrombotic.
(3) Nlekota nke ọgwụgwọ heparin: APTT nwere mmetụta dị ukwuu na mkpokọta heparin dị na plasma, yabụ ọ bụ ihe a na-ejikarị eme ihe n'ụlọ nyocha ugbu a. Ugbu a, a ga-amarịrị na nsonaazụ nha APTT ga-enwerịrị njikọ kwụ ọtọ na mkpokọta heparin dị na plasma n'usoro ọgwụgwọ, ma ọ bụghị ya, ekwesighi iji ya. N'ozuzu, n'oge ọgwụgwọ heparin, ọ dị mma ka ejiri APTT mee ihe ugboro 1.5 ruo 3.0 karịa nke njikwa nkịtị.
Nyocha nsonaazụ
N'ọgwụgwọ, a na-ejikarị APTT na PT eme ihe dị ka ule nyocha maka ọrụ coagulation ọbara. Dịka nsonaazụ nha si dị, enwere ihe dị ka ọnọdụ anọ ndị a:
(1) Ma APTT na PT bụ ihe nkịtị: E wezụga ndị nkịtị, a na-ahụ ya naanị na ụkọ FXIII nke sitere na ihe nketa na nke abụọ. Ndị a na-enweta na-abụkarị n'ọrịa imeju dị oke njọ, etuto imeju, lymphoma dị njọ, leukemia, antibody anti-factor XIII, autoimmune anaemia na pernicious anaemia.
(2) APTT dị ogologo oge nwere PT nkịtị: Ọtụtụ nsogbu ọbara ọgbụgba na-akpata site na ntụpọ dị na ụzọ coagulation intrinsic. Dịka hemophilia A, B, na factor Ⅺ deficiency; enwere anti-factor Ⅷ, Ⅸ, Ⅺ na mgbasa ọbara.
(3) APTT nkịtị nwere PT ogologo oge: ọtụtụ nsogbu ọbara ọgbụgba na-akpata site na ntụpọ na ụzọ coagulation mpụga, dị ka enweghị mkpụrụ ndụ ihe nketa na nke enwetara na factor VII. Ndị a na-ahụkarị na ọrịa imeju, DIC, anti-factor VII antibodies na mgbasa ọbara na ọgwụ mgbochi ọnụ.
(4) Ma APTT na PT na-adịte aka: ọtụtụ nsogbu ọbara ọgbụgba na-akpata site na ntụpọ na ụzọ coagulation nkịtị, dị ka enweghị mkpụrụ ndụ ihe nketa na ihe enwetara X, V, II na I. Ndị enwetara na-ahụkarị na ọrịa imeju na DIC, enwere ike ibelata ihe X na II mgbe ejiri ọgwụ mgbochi afọ. Na mgbakwunye, mgbe enwere ọgwụ mgbochi anti-factor X, anti-factor V na anti-factor II na mgbasa ọbara, ha na-agbatịkwa ogologo oge dịka o kwesịrị. Mgbe ejiri heparin mee ihe n'ụlọ ọgwụ, ma APTTT na PT na-agbatịkwa ogologo oge dịka o kwesịrị.