Lub sijhawm ua haujlwm ib nrab thromboplastin (lub sijhawm ua haujlwm ib nrab thromboplastin, APTT) yog kev kuaj mob rau kev kuaj pom "intrinsic pathway" coagulation factor defects, thiab tam sim no siv rau kev kho mob coagulation factor, heparin anticoagulant therapy monitoring, thiab kev kuaj pom lupus anticoagulant. Lub ntsiab lus tseem ceeb ntawm anti-phospholipid autoantibodies, nws cov zaus siv hauv kev kho mob yog qhov thib ob tsuas yog PT lossis sib npaug rau nws.
Qhov tseem ceeb ntawm kev kho mob
Nws yeej muaj lub ntsiab lus zoo ib yam li lub sijhawm coagulation, tab sis muaj kev nkag siab siab. Feem ntau ntawm cov txheej txheem txiav txim siab APTT siv tam sim no tuaj yeem tsis zoo thaum cov plasma coagulation factor qis dua 15% txog 30% ntawm qib ib txwm.
(1) APTT ntev dua: qhov tshwm sim APTT yog 10 vib nas this ntev dua li ntawm kev tswj hwm ib txwm muaj. APTT yog qhov kev kuaj mob txhim khu kev qha tshaj plaws rau qhov tsis muaj cov tshuaj coagulation endogenous thiab feem ntau yog siv los nrhiav pom cov hemophilia me me. Txawm hais tias qhov tseem ceeb Ⅷ: C theem tuaj yeem pom hauv qab 25% ntawm hemophilia A, qhov rhiab heev rau subclinical hemophilia (qhov tseem ceeb Ⅷ> 25%) thiab cov neeg nqa hemophilia tsis zoo. Cov txiaj ntsig ntev kuj pom hauv qhov tsis txaus ntawm qhov tseem ceeb Ⅸ (hemophilia B), Ⅺ thiab Ⅶ; thaum cov tshuaj anticoagulant ntshav xws li cov tshuaj coagulation factor inhibitors lossis heparin nce, prothrombin, fibrinogen thiab factor V, X tsis txaus kuj tuaj yeem ntev dua, tab sis qhov rhiab heev tsis zoo me ntsis; APTT ntev kuj tuaj yeem pom hauv lwm tus neeg mob uas muaj kab mob siab, DIC, thiab ntau cov ntshav banked.
(2) APTT luv luv: pom hauv DIC, lub xeev prethrombotic thiab kab mob thrombotic.
(3) Kev saib xyuas kev kho mob heparin: APTT rhiab heev rau qhov concentration ntawm plasma heparin, yog li nws yog qhov ntsuas kev soj ntsuam hauv chaw kuaj mob uas siv dav dav tam sim no. Lub sijhawm no, nws yuav tsum tau sau tseg tias qhov ntsuas APTT yuav tsum muaj kev sib raug zoo nrog cov plasma concentration ntawm heparin hauv qhov ntau ntawm kev kho mob, txwv tsis pub nws yuav tsum tsis txhob siv. Feem ntau, thaum kho mob heparin, nws raug nquahu kom tswj APTT ntawm 1.5 txog 3.0 npaug ntawm kev tswj hwm ib txwm muaj.
Kev tshuaj xyuas cov txiaj ntsig
Hauv kev kho mob, APTT thiab PT feem ntau siv los ua kev kuaj xyuas kev ua haujlwm ntawm cov ntshav coagulation. Raws li cov txiaj ntsig ntawm kev ntsuas, muaj kwv yees li plaub qhov xwm txheej hauv qab no:
(1) Ob qho tib si APTT thiab PT yog ib txwm muaj: Tsuas yog cov neeg ib txwm muaj, nws tsuas yog pom hauv kev tsis txaus FXIII los ntawm noob caj noob ces thiab theem ob. Cov uas tau txais yog feem ntau hauv kab mob siab hnyav, mob qog nqaij hlav, malignant lymphoma, leukemia, anti-factor XIII antibody, autoimmune anemia thiab pernicious anemia.
(2) APTT ntev nrog PT ib txwm muaj: Feem ntau ntawm cov teeb meem los ntshav yog tshwm sim los ntawm qhov tsis zoo hauv txoj kev coagulation intrinsic. Xws li hemophilia A, B, thiab factor Ⅺ deficiency; muaj cov tshuaj tiv thaiv Ⅷ, Ⅸ, Ⅺ hauv cov ntshav ncig.
(3) APTT ib txwm muaj nrog PT ntev: feem ntau cov teeb meem los ntshav uas tshwm sim los ntawm qhov tsis zoo hauv txoj kev coagulation sab nraud, xws li kev tsis txaus ntawm cov noob caj noob ces thiab tau txais yam tsis txaus VII. Cov uas tau txais yog cov uas muaj ntau hauv kab mob siab, DIC, cov tshuaj tiv thaiv kab mob VII hauv kev ncig ntshav thiab cov tshuaj tiv thaiv kab mob hauv qhov ncauj.
(4) Ob qho tib si APTT thiab PT yog ntev: feem ntau cov teeb meem los ntshav uas tshwm sim los ntawm qhov tsis zoo hauv txoj kev coagulation, xws li kev tshuaj ntsuam xyuas caj ces thiab tau txais yam tsis txaus X, V, II thiab I. Cov uas tau txais feem ntau pom hauv kab mob siab thiab DIC, thiab cov yam ntxwv X thiab II yuav raug txo qis thaum siv cov tshuaj anticoagulants hauv qhov ncauj. Tsis tas li ntawd, thaum muaj cov tshuaj anti-factor X, anti-factor V thiab anti-factor II hauv cov ntshav ncig, lawv kuj raug ntev raws li. Thaum siv heparin hauv kev kho mob, ob qho tib si APTTT thiab PT raug ntev raws li.
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