Koʻikoʻi lapaʻau
ʻO ke kumu, ua like ia me ka manawa coagulation, akā me ke koʻikoʻi kiʻekiʻe. ʻO ka hapa nui o nā ʻano hoʻoholo APTT i hoʻohana ʻia i kēia manawa hiki ke maʻamau ʻole ke emi ka plasma coagulation factor ma mua o 15% a 30% o ka pae maʻamau.
(1) Hoʻolōʻihi ʻia ka APTT: ʻo ka hopena APTT he 10 kekona ka lōʻihi ma mua o ka mana maʻamau. ʻO APTT ka hoʻāʻo loiloi hilinaʻi loa no ka hemahema o ka factor coagulation endogenous a hoʻohana nui ʻia e ʻike i ka hemophilia māmā. ʻOiai hiki ke ʻike ʻia nā pae factor Ⅷ: C ma lalo o 25% o ka hemophilia A, ʻaʻole maikaʻi ka ʻike i ka hemophilia subclinical (factor Ⅷ>25%) a me nā mea lawe hemophilia. ʻIke ʻia nā hopena lōʻihi i nā hemahema factor Ⅸ (hemophilia B), Ⅺ a me Ⅶ; i ka wā e piʻi ai nā mea anticoagulant koko e like me nā mea hoʻopaʻa factor coagulation a i ʻole nā ​​​​pae heparin, prothrombin, fibrinogen a me factor V, X hemahema pū kekahi Hiki ke hoʻolōʻihi ʻia, akā ʻaʻole maikaʻi iki ka ʻike; Hiki ke ʻike ʻia ka hoʻolōʻihi ʻana o ka APTT i nā poʻe maʻi ʻē aʻe me ka maʻi akepaʻa, DIC, a me ka nui o ke koko i mālama ʻia.
(2) Hoʻopōkole ʻana o APTT: ʻike ʻia ma DIC, ke kūlana prethrombotic a me ka maʻi thrombotic.
(3) Ka nānā ʻana i ka lāʻau heparin: He ʻike nui ka APTT i ka nui o ka heparin plasma, no laila he ʻōkuhi nānā hale hana i hoʻohana nui ʻia i kēia manawa. I kēia manawa, pono e hoʻomaopopo ʻia he pono ka hopena ana o ka APTT e loaʻa kahi pilina linear me ka nui o ka heparin plasma i ka pae therapeutic, inā ʻaʻole pono e hoʻohana ʻia. Ma ke ʻano laulā, i ka wā o ka lāʻau heparin, he mea kūpono ke mālama i ka APTT ma 1.5 a 3.0 mau manawa o ka mana maʻamau.
Ka loiloi hopena
Ma ke ʻano lapaʻau, hoʻohana pinepine ʻia ʻo APTT a me PT ma ke ʻano he mau hoʻāʻo nānā no ka hana coagulation koko. Wahi a nā hopena o ke ana ʻana, aia ma kahi o ʻehā mau kūlana:
(1) He maʻamau nā APTT a me PT: Koe wale nō nā kānaka maʻamau, ʻike wale ʻia ia ma ka hemahema FXIII hoʻoilina a me ka lua. ʻO nā mea i loaʻa he mea maʻamau i nā maʻi akepaʻa koʻikoʻi, ka puʻupuʻu akepaʻa, ka lymphoma malignant, ka leukemia, ka antibody anti-factor XIII, ka anemia autoimmune a me ka anemia pernicious.
(2) APTT lōʻihi me ka PT maʻamau: ʻO ka hapa nui o nā maʻi kahe koko e hana ʻia e nā hemahema i ke ala coagulation intrinsic. E like me ka hemophilia A, B, a me ka hemahema o ka factor Ⅺ; aia nā antibodies anti-factor Ⅷ, Ⅸ, Ⅺ i loko o ke kahe koko.
(3) APTT maʻamau me ka PT lōʻihi: ʻo ka hapa nui o nā maʻi kahe koko i hoʻokumu ʻia e nā hemahema i ke ala coagulation extrinsic, e like me ka genetic a me ka hemahema factor VII i loaʻa. ʻO nā mea i loaʻa he mea maʻamau i nā maʻi ate, DIC, nā antibodies anti-factor VII i ke kahe koko a me nā anticoagulants waha.
(4) Ua hoʻolōʻihi ʻia ka APTT a me ka PT: ʻo ka hapa nui o nā maʻi kahe koko i hoʻokumu ʻia e nā hemahema i ke ala coagulation maʻamau, e like me ka genetic a me ka hemahema o ka factor X, V, II a me I. ʻIke nui ʻia nā mea i loaʻa i nā maʻi akepaʻa a me DIC, a hiki ke hoʻemi ʻia nā factor X a me II ke hoʻohana ʻia nā anticoagulants waha. Eia kekahi, i ka wā e loaʻa ai nā antibodies anti-factor X, anti-factor V a me anti-factor II i ke kahe koko, ua hoʻolōʻihi ʻia lākou e like me ia. Ke hoʻohana ʻia ka heparin ma ke ʻano lapaʻau, ua hoʻolōʻihi ʻia ʻo APTTT a me PT e like me ia.