Muhimmancin asibiti
Ainihin ma'anarsa iri ɗaya ce da lokacin coagulation, amma tare da babban ƙarfin ji. Yawancin hanyoyin tantance APTT da ake amfani da su a yanzu na iya zama marasa kyau idan ma'aunin coagulation na plasma ya ƙasa da kashi 15% zuwa 30% na matakin da aka saba.
(1) Tsawaita APTT: Sakamakon APTT ya fi na sarrafawa na yau da kullun tsawon daƙiƙa 10. APTT ita ce gwajin tantancewa mafi inganci don ƙarancin abubuwan haɗin jini na ciki kuma galibi ana amfani da ita don gano ƙananan hemophilia. Duk da cewa factor Ⅷ: Ana iya gano matakan C ƙasa da 25% na hemophilia A, jin daɗin hemophilia na ƙarƙashin asibiti (factor Ⅷ>25%) da masu ɗauke da hemophilia ba shi da kyau. Ana kuma ganin sakamako mai tsawo a cikin factor Ⅸ (hemophilia B), Ⅺ da Ⅶ rashin ƙarfi; lokacin da abubuwan hana zubar jini na jini kamar su hana zubar jini ko matakan heparin suka ƙaru, ƙarancin prothrombin, fibrinogen da factor V, X kuma ana iya tsawaita shi, amma jin daɗin ba shi da kyau; Ana iya ganin tsawaita APTT a wasu marasa lafiya da ke fama da cutar hanta, DIC, da kuma yawan jinin da aka ajiye.
(2) Rage APTT: ana gani a cikin DIC, yanayin kafin thrombosis da cututtukan thrombosis.
(3) Kula da maganin heparin: APTT yana da matukar tasiri ga yawan heparin a cikin jini, don haka ma'aunin sa ido ne da ake amfani da shi sosai a dakin gwaje-gwaje a halin yanzu. A wannan lokacin, ya kamata a lura cewa sakamakon auna APTT dole ne ya kasance yana da alaƙa ta layi tare da yawan heparin a cikin jini a cikin kewayon magani, in ba haka ba bai kamata a yi amfani da shi ba. Gabaɗaya, yayin maganin heparin, yana da kyau a kiyaye APTT sau 1.5 zuwa 3.0 fiye da yadda aka saba.
Binciken sakamako
A asibiti, ana amfani da APTT da PT a matsayin gwaje-gwajen tantancewa don aikin coagulation na jini. Dangane da sakamakon aunawa, akwai kusan yanayi huɗu masu zuwa:
(1) APTT da PT duka al'ada ne: Banda ga mutanen da ba su da lafiya, ana ganinsa ne kawai a cikin rashin FXIII na gado da na biyu. Waɗanda aka samu suna da yawa a cikin cututtukan hanta masu tsanani, ciwon hanta, cutar sankarar bargo, cutar sankarar bargo, anti-factor XIII, cutar kansar jiki da kuma cutar sankarar bargo mai illa.
(2) Tsawaita APTT tare da PT na yau da kullun: Yawancin matsalolin zubar jini suna faruwa ne sakamakon lahani a cikin hanyar coagulation ta ciki. Kamar hemophilia A, B, da ƙarancin factor Ⅺ; akwai anti-factor Ⅷ, Ⅸ, Ⅺ a cikin zagayawar jini.
(3) APTT na yau da kullun tare da PT mai tsawo: yawancin matsalolin zubar jini da ke faruwa sakamakon lahani a cikin hanyar coagulation ta waje, kamar ƙarancin kwayoyin halitta da kuma ƙarancin factor VII da aka samu. Waɗanda aka samu sun zama ruwan dare a cikin cututtukan hanta, DIC, anti-factor VII antibodies a cikin zagayawar jini da magungunan hana zubar jini ta baki.
(4) Dukansu APTT da PT suna tsawaitawa: yawancin matsalolin zubar jini da ke faruwa sakamakon lahani a cikin hanyar coagulation na gama gari, kamar ƙarancin kwayoyin halitta da aka samu na factor X, V, II da I. Waɗanda aka samu galibi ana ganin su a cikin cututtukan hanta da DIC, kuma ana iya rage abubuwan X da II lokacin da aka yi amfani da magungunan hana zubar jini na baki. Bugu da ƙari, idan akwai magungunan hana daukar ciki na X, anti-factor V da anti-factor II a cikin zagayawar jini, ana kuma tsawaita su gwargwadon haka. Idan aka yi amfani da heparin a asibiti, duka APTTT da PT ana tsawaita su gwargwadon haka.