Isikhathi se-Prothrombin (PT) sibhekisela esikhathini esidingekayo sokujiya kwe-plasma ngemva kokuguqulwa kwe-prothrombin ibe yi-thrombin ngemva kokwengeza i-thromboplastin yezicubu eziningi kanye nenani elifanele lama-ion e-calcium abe yi-plasma engenawo ama-platelet. Isikhathi se-prothrombin esiphezulu (PT), okungukuthi, ukwelulwa kwesikhathi, singabangelwa yizizathu ezahlukahlukene ezifana nezinto zokuzalwa ezingavamile zokujiya, izinto zokuzalwa ezingavamile zokujiya, isimo esingavamile sokujiya kwegazi, njll. Ukuhlaziywa okuyinhloko kungokulandelayo:

1. Izici ezingavamile zokuzala ezibangela ukujiya kwegazi: Ukukhiqizwa okungajwayelekile kwanoma yiziphi izici zokuqina kwe-I, II, V, VII, kanye no-X emzimbeni kuzoholela esikhathini eside se-prothrombin (PT). Iziguli zinganezela izici zokuqina kwe-coagulation ngaphansi kwesiqondiso sodokotela ukuze kuthuthukiswe lesi simo;

2. Izinto ezingavamile zokubopha igazi: isifo esivamile esibi sesibindi, ukuntuleka kwe-vitamin K, i-hyperfibrinolysis, ukujiya kwemithambo yegazi okusabalele, njll., lezi zici zizoholela ekushodeni kwezici zokujiya ezigulini, okuholela esikhathini eside se-prothrombin (PT). Izimbangela ezithile zidinga ukutholakala ukuze kutholakale ukwelashwa okuqondiwe. Isibonelo, iziguli ezinesifo se-vitamin K zingelashwa ngokufaka i-vitamin K1 emthanjeni ukuze kukhuthazwe ukubuyela kwesikhathi se-prothrombin esimweni esijwayelekile;

3. Isimo esingavamile sokuvimbela ukujiya kwegazi: kukhona izinto ezivimbela ukugaywa kwegazi egazini noma isiguli sisebenzisa izidakamizwa ezivimbela ukugaywa kwegazi, njenge-aspirin kanye neminye imithi, enemiphumela evimbela ukugaywa kwegazi, ezothinta indlela yokugaywa kwegazi futhi yandise isikhathi se-prothrombin (PT). Kunconywa ukuthi iziguli ziyeke imithi evimbela ukugaywa kwegazi ngaphansi kokuqondiswa odokotela futhi zishintshele kwezinye izindlela zokwelapha.

Isikhathi se-prothrombin (PT) esinwetshwa ngemizuzwana engaphezu kwemi-3 sinokubaluleka komtholampilo. Uma siphezulu kakhulu futhi singadluli inani elijwayelekile imizuzwana emi-3, singabhekwa eduze, futhi ukwelashwa okukhethekile ngokuvamile akudingeki. Uma isikhathi se-prothrombin (PT) sinwetshwa isikhathi eside kakhulu, kuyadingeka ukuthola imbangela ethile futhi wenze ukwelashwa okuqondiwe.